Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men
Abstract Aims Majority of diabetic male patients have disturbances in their reproductive systems. However, the mechanisms underlying these disturbances are largely unknown. Since advanced glycation end products (AGE) have a key role in oxidative stress and cell damage in diabetic complications, we h...
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| Veröffentlicht in: | Diabetes research and clinical practice 2011-01, Vol.91 (1), p.61-66 |
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| creator | Karimi, J Goodarzi, M.T Tavilani, H Khodadadi, I Amiri, I |
| description | Abstract Aims Majority of diabetic male patients have disturbances in their reproductive systems. However, the mechanisms underlying these disturbances are largely unknown. Since advanced glycation end products (AGE) have a key role in oxidative stress and cell damage in diabetic complications, we hypothesize that AGEs may be involved sperm lipid peroxidation. Methods Total AGEs in seminal plasma of 32 diabetic and 35 non-diabetic men was determined by spectrofluorimetric method and carboxy methyl lysine (CML) level was assayed using ELISA. Contents of lipid peroxidation in sperm and seminal plasma were determined by thiobarbituric acid reaction. Total antioxidant capacity (TAC) was measured by a colorimetric assay. Results Total AGEs were found significantly higher in seminal plasma of diabetic men than non-diabetic group ( p < 0.001) whereas no significant differences in seminal plasma CML values between two groups was observed. Moreover, sperm and seminal plasma lipid peroxidation were significantly higher in diabetic subjects than non-diabetic men and a significantly lower TAC was detected in diabetic group compare to non-diabetics. Conclusions These results showed an increment in AGEs in seminal plasma of diabetic subjects and may suggest a key role for glycation process and increased oxidative stress in reproductive system dysfunction. |
| doi_str_mv | 10.1016/j.diabres.2010.09.024 |
| format | Article |
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However, the mechanisms underlying these disturbances are largely unknown. Since advanced glycation end products (AGE) have a key role in oxidative stress and cell damage in diabetic complications, we hypothesize that AGEs may be involved sperm lipid peroxidation. Methods Total AGEs in seminal plasma of 32 diabetic and 35 non-diabetic men was determined by spectrofluorimetric method and carboxy methyl lysine (CML) level was assayed using ELISA. Contents of lipid peroxidation in sperm and seminal plasma were determined by thiobarbituric acid reaction. Total antioxidant capacity (TAC) was measured by a colorimetric assay. Results Total AGEs were found significantly higher in seminal plasma of diabetic men than non-diabetic group ( p < 0.001) whereas no significant differences in seminal plasma CML values between two groups was observed. Moreover, sperm and seminal plasma lipid peroxidation were significantly higher in diabetic subjects than non-diabetic men and a significantly lower TAC was detected in diabetic group compare to non-diabetics. Conclusions These results showed an increment in AGEs in seminal plasma of diabetic subjects and may suggest a key role for glycation process and increased oxidative stress in reproductive system dysfunction.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2010.09.024</identifier><identifier>PMID: 20970866</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Advanced glycation endproducts ; Antioxidants ; Blood Glucose - analysis ; Diabetes Complications - metabolism ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - physiopathology ; Endocrinology & Metabolism ; Glycated Hemoglobin A - analysis ; Glycation End Products, Advanced - metabolism ; Humans ; Infertility, Male - metabolism ; Lipid Peroxidation ; Lysine - analogs & derivatives ; Lysine - metabolism ; Male ; Malondialdehyde - metabolism ; Middle Aged ; Oxidative Stress ; Semen - metabolism ; Spermatozoa ; Spermatozoa - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism ; Total antioxidant capacity ; Young Adult</subject><ispartof>Diabetes research and clinical practice, 2011-01, Vol.91 (1), p.61-66</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-e1c84d4d7b291d416e3422a826d5c6db7060fc0372c555b0e3be4e6910020ce13</citedby><cites>FETCH-LOGICAL-c485t-e1c84d4d7b291d416e3422a826d5c6db7060fc0372c555b0e3be4e6910020ce13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2010.09.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20970866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karimi, J</creatorcontrib><creatorcontrib>Goodarzi, M.T</creatorcontrib><creatorcontrib>Tavilani, H</creatorcontrib><creatorcontrib>Khodadadi, I</creatorcontrib><creatorcontrib>Amiri, I</creatorcontrib><title>Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Aims Majority of diabetic male patients have disturbances in their reproductive systems. However, the mechanisms underlying these disturbances are largely unknown. Since advanced glycation end products (AGE) have a key role in oxidative stress and cell damage in diabetic complications, we hypothesize that AGEs may be involved sperm lipid peroxidation. Methods Total AGEs in seminal plasma of 32 diabetic and 35 non-diabetic men was determined by spectrofluorimetric method and carboxy methyl lysine (CML) level was assayed using ELISA. Contents of lipid peroxidation in sperm and seminal plasma were determined by thiobarbituric acid reaction. Total antioxidant capacity (TAC) was measured by a colorimetric assay. Results Total AGEs were found significantly higher in seminal plasma of diabetic men than non-diabetic group ( p < 0.001) whereas no significant differences in seminal plasma CML values between two groups was observed. Moreover, sperm and seminal plasma lipid peroxidation were significantly higher in diabetic subjects than non-diabetic men and a significantly lower TAC was detected in diabetic group compare to non-diabetics. Conclusions These results showed an increment in AGEs in seminal plasma of diabetic subjects and may suggest a key role for glycation process and increased oxidative stress in reproductive system dysfunction.</description><subject>Adult</subject><subject>Advanced glycation endproducts</subject><subject>Antioxidants</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Complications - metabolism</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Endocrinology & Metabolism</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Humans</subject><subject>Infertility, Male - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Semen - metabolism</subject><subject>Spermatozoa</subject><subject>Spermatozoa - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Total antioxidant capacity</subject><subject>Young Adult</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P1DAMhiMEYoeFnwDKjdMMTpqm7QWEVnxJKyHxcY5SxwMeOumQtLvMvyfdGThw4ZQ4fv3aeSzEUwUbBcq-2G0C-z5R3mgob9BtQJt7YqXaRq9brZv7YlV07d39QjzKeQcAtjL1Q3GhoWugtXYl4ica_MRjzN_5IHuabomi9OHGR6Qgvw1HvEtLikEe0hhmnLL0JeCIiXwuooEPXJKUxl8cTmqOMtO-OI1bucxJE6Ms8WPxYOuHTE_O56X4-vbNl6v36-uP7z5cvb5eo2nraU0KWxNMaHrdqWCUpcpo7VttQ4029A1Y2CJUjca6rnugqidDtlMAGpBUdSmen3zLyD9nypPbc0YaBh9pnLNrtao7axtdlPVJiWnMOdHWHRLvfTo6BW4h7XbuTNotpB10rpAudc_OHeZ-T-Fv1R-0RfDqJKDyzxum5DIyLVQ5EU4ujPzfFi__ccCBI6MfftCR8m6cUywQnXJZO3Cfl3Uv2y4UwHSVrX4DcF-oBQ</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Karimi, J</creator><creator>Goodarzi, M.T</creator><creator>Tavilani, H</creator><creator>Khodadadi, I</creator><creator>Amiri, I</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men</title><author>Karimi, J ; Goodarzi, M.T ; Tavilani, H ; Khodadadi, I ; Amiri, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-e1c84d4d7b291d416e3422a826d5c6db7060fc0372c555b0e3be4e6910020ce13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Advanced glycation endproducts</topic><topic>Antioxidants</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Complications - metabolism</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Endocrinology & Metabolism</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Humans</topic><topic>Infertility, Male - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Semen - metabolism</topic><topic>Spermatozoa</topic><topic>Spermatozoa - metabolism</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Total antioxidant capacity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karimi, J</creatorcontrib><creatorcontrib>Goodarzi, M.T</creatorcontrib><creatorcontrib>Tavilani, H</creatorcontrib><creatorcontrib>Khodadadi, I</creatorcontrib><creatorcontrib>Amiri, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karimi, J</au><au>Goodarzi, M.T</au><au>Tavilani, H</au><au>Khodadadi, I</au><au>Amiri, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>91</volume><issue>1</issue><spage>61</spage><epage>66</epage><pages>61-66</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Aims Majority of diabetic male patients have disturbances in their reproductive systems. However, the mechanisms underlying these disturbances are largely unknown. Since advanced glycation end products (AGE) have a key role in oxidative stress and cell damage in diabetic complications, we hypothesize that AGEs may be involved sperm lipid peroxidation. Methods Total AGEs in seminal plasma of 32 diabetic and 35 non-diabetic men was determined by spectrofluorimetric method and carboxy methyl lysine (CML) level was assayed using ELISA. Contents of lipid peroxidation in sperm and seminal plasma were determined by thiobarbituric acid reaction. Total antioxidant capacity (TAC) was measured by a colorimetric assay. Results Total AGEs were found significantly higher in seminal plasma of diabetic men than non-diabetic group ( p < 0.001) whereas no significant differences in seminal plasma CML values between two groups was observed. Moreover, sperm and seminal plasma lipid peroxidation were significantly higher in diabetic subjects than non-diabetic men and a significantly lower TAC was detected in diabetic group compare to non-diabetics. Conclusions These results showed an increment in AGEs in seminal plasma of diabetic subjects and may suggest a key role for glycation process and increased oxidative stress in reproductive system dysfunction.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20970866</pmid><doi>10.1016/j.diabres.2010.09.024</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Advanced glycation endproducts Antioxidants Blood Glucose - analysis Diabetes Complications - metabolism Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Endocrinology & Metabolism Glycated Hemoglobin A - analysis Glycation End Products, Advanced - metabolism Humans Infertility, Male - metabolism Lipid Peroxidation Lysine - analogs & derivatives Lysine - metabolism Male Malondialdehyde - metabolism Middle Aged Oxidative Stress Semen - metabolism Spermatozoa Spermatozoa - metabolism Thiobarbituric Acid Reactive Substances - metabolism Total antioxidant capacity Young Adult |
| title | Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men |
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