Impact of Cytochrome P450 2C192 Polymorphism on Intra-Stent Thrombus After Drug-Eluting Stent Implantation in Japanese Patients Receiving Clopidogrel

Background: The cytochrome P450 (CYP) 2C19*2 polymorphism is associated with reduced responsiveness to clopidogrel and poor clinical outcome after stent implantation. Despite the high frequency of this polymorphism in Japanese patients, its contribution to cardiac events and stent thrombi after drug...

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Veröffentlicht in:	Circulation Journal 2011, Vol.75(1), pp.99-105
Hauptverfasser:	Sawada, Takahiro, Shinke, Toshiro, Shite, Junya, Honjo, Tomoyuki, Haraguchi, Yoko, Nishio, Ryo, Shinohara, Masakazu, Toh, Ryuji, Ishida, Tatsuro, Kawamori, Hiroyuki, Kozuki, Amane, Inoue, Takumi, Hariki, Hirotoshi, Hirata, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - instrumentation Angioplasty, Balloon, Coronary - mortality Aryl Hydrocarbon Hydroxylases - genetics Asian Continental Ancestry Group - genetics Cardiovascular Agents - administration & dosage Chi-Square Distribution Cineangiography Clopidogrel CYP2c192 polymorphism Cytochrome P-450 CYP2C19 Drug-eluting stent thrombus Drug-Eluting Stents Female Gene Frequency Genetic Predisposition to Disease Humans Japan Logistic Models Male Middle Aged Myocardial Infarction - enzymology Myocardial Infarction - genetics Optical coherence tomography Paclitaxel - administration & dosage Phenotype Platelet Aggregation Inhibitors - therapeutic use Polymorphism, Genetic Prosthesis Design Risk Assessment Risk Factors Sirolimus - administration & dosage Thrombosis - diagnosis Thrombosis - enzymology Thrombosis - genetics Thrombosis - mortality Thrombosis - prevention & control Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use Time Factors Tomography, Optical Coherence Treatment Outcome
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