Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects
Abstract Purpose Alpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function. We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid red...
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| creator | Koh, Eun Hee, MD Lee, Woo Je, MD Lee, Sang Ah, MD Kim, Eun Hee, MD Cho, Eun Hee, MD Jeong, Eunheui, MD Kim, Dong Woo, MD Kim, Min-Seon, MD Park, Joong-Yeol, MD Park, Keun-Gyu, MD Lee, Hyo-Jung, PhD Lee, In-Kyu, MD Lim, Soo, MD Jang, Hak Chul, MD Lee, Ki Hoon, PhD Lee, Ki-Up, MD |
| description | Abstract Purpose Alpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function. We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects. Methods In this randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (body mass index [BMI] ≥30 kg/m2 or BMI 27-30 kg/m2 plus hypertension, diabetes mellitus, or hypercholesterolemia) were randomized to alpha-lipoic acid 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline to end point. Results The 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group (2.1%; 95% confidence interval, 1.4-2.8; P < .05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient. Conclusion Alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity. |
| doi_str_mv | 10.1016/j.amjmed.2010.08.005 |
| format | Article |
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We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects. Methods In this randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (body mass index [BMI] ≥30 kg/m2 or BMI 27-30 kg/m2 plus hypertension, diabetes mellitus, or hypercholesterolemia) were randomized to alpha-lipoic acid 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline to end point. Results The 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group (2.1%; 95% confidence interval, 1.4-2.8; P < .05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient. Conclusion Alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/j.amjmed.2010.08.005</identifier><identifier>PMID: 21187189</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Alpha-lipoic acid ; Anti-obesity agent ; Body Weight - drug effects ; Double-Blind Method ; Female ; Humans ; Internal Medicine ; Male ; Obesity - drug therapy ; Side effect ; Thioctic Acid - adverse effects ; Thioctic Acid - therapeutic use</subject><ispartof>The American journal of medicine, 2011, Vol.124 (1), p.85.e1-85.e8</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-b683592fb0d027f9347545fb12630bbbcffda686965e96aba41442d1b4365f663</citedby><cites>FETCH-LOGICAL-c561t-b683592fb0d027f9347545fb12630bbbcffda686965e96aba41442d1b4365f663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002934310007436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21187189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, Eun Hee, MD</creatorcontrib><creatorcontrib>Lee, Woo Je, MD</creatorcontrib><creatorcontrib>Lee, Sang Ah, MD</creatorcontrib><creatorcontrib>Kim, Eun Hee, MD</creatorcontrib><creatorcontrib>Cho, Eun Hee, MD</creatorcontrib><creatorcontrib>Jeong, Eunheui, MD</creatorcontrib><creatorcontrib>Kim, Dong Woo, MD</creatorcontrib><creatorcontrib>Kim, Min-Seon, MD</creatorcontrib><creatorcontrib>Park, Joong-Yeol, MD</creatorcontrib><creatorcontrib>Park, Keun-Gyu, MD</creatorcontrib><creatorcontrib>Lee, Hyo-Jung, PhD</creatorcontrib><creatorcontrib>Lee, In-Kyu, MD</creatorcontrib><creatorcontrib>Lim, Soo, MD</creatorcontrib><creatorcontrib>Jang, Hak Chul, MD</creatorcontrib><creatorcontrib>Lee, Ki Hoon, PhD</creatorcontrib><creatorcontrib>Lee, Ki-Up, MD</creatorcontrib><title>Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Abstract Purpose Alpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function. We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects. Methods In this randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (body mass index [BMI] ≥30 kg/m2 or BMI 27-30 kg/m2 plus hypertension, diabetes mellitus, or hypercholesterolemia) were randomized to alpha-lipoic acid 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline to end point. Results The 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group (2.1%; 95% confidence interval, 1.4-2.8; P < .05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient. Conclusion Alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity.</description><subject>Adult</subject><subject>Alpha-lipoic acid</subject><subject>Anti-obesity agent</subject><subject>Body Weight - drug effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Obesity - drug therapy</subject><subject>Side effect</subject><subject>Thioctic Acid - adverse effects</subject><subject>Thioctic Acid - therapeutic use</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP4zAURi0EgvL4Bwh5x2xSbMd2kgUjdVB5SJVYAGJp2c41OKRxiRuk_nscFTYshpVf57vXOhehU0qmlFB50Uz1sllCPWUkXZFySojYQRMqhMgKKtkumhBCWFblPD9AhzE26UgqIffRAaO0LGhZTdDl3Dmw64iDw7N29aqzhV8Fb_HM-hqHDv8L9QY_g395XWPf4XsDEfDDYJoxdYz2nG4jnHytR-jpev54dZst7m_urmaLzApJ15mRZS4q5gypCStc-lEhuHCGMpkTY4x1rtaylJUUUEltNKecs5oankvhpMyP0Pm27qoP7wPEtVr6aKFtdQdhiKpkVFRCFCP5579kUkcZkTnnCeVb1PYhxh6cWvV-qftNgkZOqkZtFatRsSKlSopT7Oyrw2DGt-_Qt9ME_N0CkIx8eOhVtB46C7XvkzRVB_9bh58FbOs7b3X7BhuITRj6LtlWVEWmiHoYxzxOmaZNkZTln4peoBo</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Koh, Eun Hee, MD</creator><creator>Lee, Woo Je, MD</creator><creator>Lee, Sang Ah, MD</creator><creator>Kim, Eun Hee, MD</creator><creator>Cho, Eun Hee, MD</creator><creator>Jeong, Eunheui, MD</creator><creator>Kim, Dong Woo, MD</creator><creator>Kim, Min-Seon, MD</creator><creator>Park, Joong-Yeol, MD</creator><creator>Park, Keun-Gyu, MD</creator><creator>Lee, Hyo-Jung, PhD</creator><creator>Lee, In-Kyu, MD</creator><creator>Lim, Soo, MD</creator><creator>Jang, Hak Chul, MD</creator><creator>Lee, Ki Hoon, PhD</creator><creator>Lee, Ki-Up, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects</title><author>Koh, Eun Hee, MD ; Lee, Woo Je, MD ; Lee, Sang Ah, MD ; Kim, Eun Hee, MD ; Cho, Eun Hee, MD ; Jeong, Eunheui, MD ; Kim, Dong Woo, MD ; Kim, Min-Seon, MD ; Park, Joong-Yeol, MD ; Park, Keun-Gyu, MD ; Lee, Hyo-Jung, PhD ; Lee, In-Kyu, MD ; Lim, Soo, MD ; Jang, Hak Chul, MD ; Lee, Ki Hoon, PhD ; Lee, Ki-Up, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-b683592fb0d027f9347545fb12630bbbcffda686965e96aba41442d1b4365f663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alpha-lipoic acid</topic><topic>Anti-obesity agent</topic><topic>Body Weight - drug effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Obesity - drug therapy</topic><topic>Side effect</topic><topic>Thioctic Acid - adverse effects</topic><topic>Thioctic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koh, Eun Hee, MD</creatorcontrib><creatorcontrib>Lee, Woo Je, MD</creatorcontrib><creatorcontrib>Lee, Sang Ah, MD</creatorcontrib><creatorcontrib>Kim, Eun Hee, MD</creatorcontrib><creatorcontrib>Cho, Eun Hee, MD</creatorcontrib><creatorcontrib>Jeong, Eunheui, MD</creatorcontrib><creatorcontrib>Kim, Dong Woo, MD</creatorcontrib><creatorcontrib>Kim, Min-Seon, MD</creatorcontrib><creatorcontrib>Park, Joong-Yeol, MD</creatorcontrib><creatorcontrib>Park, Keun-Gyu, MD</creatorcontrib><creatorcontrib>Lee, Hyo-Jung, PhD</creatorcontrib><creatorcontrib>Lee, In-Kyu, MD</creatorcontrib><creatorcontrib>Lim, Soo, MD</creatorcontrib><creatorcontrib>Jang, Hak Chul, MD</creatorcontrib><creatorcontrib>Lee, Ki Hoon, PhD</creatorcontrib><creatorcontrib>Lee, Ki-Up, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koh, Eun Hee, MD</au><au>Lee, Woo Je, MD</au><au>Lee, Sang Ah, MD</au><au>Kim, Eun Hee, MD</au><au>Cho, Eun Hee, MD</au><au>Jeong, Eunheui, MD</au><au>Kim, Dong Woo, MD</au><au>Kim, Min-Seon, MD</au><au>Park, Joong-Yeol, MD</au><au>Park, Keun-Gyu, MD</au><au>Lee, Hyo-Jung, PhD</au><au>Lee, In-Kyu, MD</au><au>Lim, Soo, MD</au><au>Jang, Hak Chul, MD</au><au>Lee, Ki Hoon, PhD</au><au>Lee, Ki-Up, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>2011</date><risdate>2011</risdate><volume>124</volume><issue>1</issue><spage>85.e1</spage><epage>85.e8</epage><pages>85.e1-85.e8</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>Abstract Purpose Alpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function. We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects. Methods In this randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (body mass index [BMI] ≥30 kg/m2 or BMI 27-30 kg/m2 plus hypertension, diabetes mellitus, or hypercholesterolemia) were randomized to alpha-lipoic acid 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline to end point. Results The 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group (2.1%; 95% confidence interval, 1.4-2.8; P < .05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient. Conclusion Alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21187189</pmid><doi>10.1016/j.amjmed.2010.08.005</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alpha-lipoic acid Anti-obesity agent Body Weight - drug effects Double-Blind Method Female Humans Internal Medicine Male Obesity - drug therapy Side effect Thioctic Acid - adverse effects Thioctic Acid - therapeutic use |
| title | Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects |
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