Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women
Objective: It is well known that individuals with anorexia nervosa (AN) are inhibited and over‐controlled. This study investigated a prefrontal‐cingulate network that is involved in inhibitory control. Method: To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 ma...
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| Veröffentlicht in: | The International journal of eating disorders 2011-01, Vol.44 (1), p.1-8 |
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| container_title | The International journal of eating disorders |
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| creator | Oberndorfer, Tyson A. Kaye, Walter H. Simmons, Alan N. Strigo, Irina A. Matthews, Scott C. |
| description | Objective:
It is well known that individuals with anorexia nervosa (AN) are inhibited and over‐controlled. This study investigated a prefrontal‐cingulate network that is involved in inhibitory control.
Method:
To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during functional magnetic resonance imaging.
Results:
Consistent with the a priori hypothesis, RAN subjects showed altered task‐related activation in the medial prefrontal cortex (mPFC), a critical node of the inhibitory control network. Specifically, whereas RAN and CW showed similar mPFC acitivity during trials when inhibitory demand was low (i.e., easy trials), RAN relative to CW showed significantly less mPFC activation as inhibition trials became more difficult (i.e., hard trials), suggesting a demand‐specific modulation of inhibitory control circuitry in RAN.
Discussion:
These findings support a neural basis for altered impulse control symptoms in AN © © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:1–8) |
| doi_str_mv | 10.1002/eat.20750 |
| format | Article |
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It is well known that individuals with anorexia nervosa (AN) are inhibited and over‐controlled. This study investigated a prefrontal‐cingulate network that is involved in inhibitory control.
Method:
To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during functional magnetic resonance imaging.
Results:
Consistent with the a priori hypothesis, RAN subjects showed altered task‐related activation in the medial prefrontal cortex (mPFC), a critical node of the inhibitory control network. Specifically, whereas RAN and CW showed similar mPFC acitivity during trials when inhibitory demand was low (i.e., easy trials), RAN relative to CW showed significantly less mPFC activation as inhibition trials became more difficult (i.e., hard trials), suggesting a demand‐specific modulation of inhibitory control circuitry in RAN.
Discussion:
These findings support a neural basis for altered impulse control symptoms in AN © © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:1–8)</description><identifier>ISSN: 0276-3478</identifier><identifier>EISSN: 1098-108X</identifier><identifier>DOI: 10.1002/eat.20750</identifier><identifier>PMID: 20127942</identifier><identifier>CODEN: INDIDJ</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Adult and adolescent clinical studies ; Anorexia ; Anorexia nervosa ; Anorexia Nervosa - physiopathology ; Anorexia Nervosa - rehabilitation ; Biological and medical sciences ; Brain ; Disruptive, Impulse Control, and Conduct Disorders - physiopathology ; Eating behavior disorders ; Eating disorders ; Female ; fMRI ; Humans ; inhibition ; Inhibition (Psychology) ; Medical sciences ; NMR ; Nuclear magnetic resonance ; prefrontal cortex ; Prefrontal Cortex - physiology ; Psychobiology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; stop task ; Task Performance and Analysis ; Women ; Young Adult</subject><ispartof>The International journal of eating disorders, 2011-01, Vol.44 (1), p.1-8</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Wiley Periodicals Inc. Jan 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4850-ffa772dc36ec233a4efa51c9c8fd9bef598fa1eb00f971f2859e4666b254fe643</citedby><cites>FETCH-LOGICAL-c4850-ffa772dc36ec233a4efa51c9c8fd9bef598fa1eb00f971f2859e4666b254fe643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feat.20750$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feat.20750$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23794686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20127942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oberndorfer, Tyson A.</creatorcontrib><creatorcontrib>Kaye, Walter H.</creatorcontrib><creatorcontrib>Simmons, Alan N.</creatorcontrib><creatorcontrib>Strigo, Irina A.</creatorcontrib><creatorcontrib>Matthews, Scott C.</creatorcontrib><title>Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women</title><title>The International journal of eating disorders</title><addtitle>Int. J. Eat. Disord</addtitle><description>Objective:
It is well known that individuals with anorexia nervosa (AN) are inhibited and over‐controlled. This study investigated a prefrontal‐cingulate network that is involved in inhibitory control.
Method:
To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during functional magnetic resonance imaging.
Results:
Consistent with the a priori hypothesis, RAN subjects showed altered task‐related activation in the medial prefrontal cortex (mPFC), a critical node of the inhibitory control network. Specifically, whereas RAN and CW showed similar mPFC acitivity during trials when inhibitory demand was low (i.e., easy trials), RAN relative to CW showed significantly less mPFC activation as inhibition trials became more difficult (i.e., hard trials), suggesting a demand‐specific modulation of inhibitory control circuitry in RAN.
Discussion:
These findings support a neural basis for altered impulse control symptoms in AN © © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:1–8)</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anorexia</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Anorexia Nervosa - rehabilitation</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - physiopathology</subject><subject>Eating behavior disorders</subject><subject>Eating disorders</subject><subject>Female</subject><subject>fMRI</subject><subject>Humans</subject><subject>inhibition</subject><subject>Inhibition (Psychology)</subject><subject>Medical sciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>prefrontal cortex</subject><subject>Prefrontal Cortex - physiology</subject><subject>Psychobiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>stop task</subject><subject>Task Performance and Analysis</subject><subject>Women</subject><subject>Young Adult</subject><issn>0276-3478</issn><issn>1098-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UtPFTEUB_DGaOSKLvwCZmJCjIuBPmb6WBJANEGMER-7ptM51cJMO7QzAt-eyr1gYuKqbfo7p835I_SS4F2CMd0DM-9SLFr8CK0IVrImWP54jFaYCl6zRsgt9Cznc4wxZ7h9irYoJlSohq7QcgijCX2dJ7DeeVuZYYZkZh9DFV01Qu_NUE0JXIphLlsb0wzXVYI8xZCh6pfkw8_KhMqHX77zd5WzyRflXJSNvyFBX-5jguvS_yqOEJ6jJ84MGV5s1m309d3R2cH7-uTT8YeD_ZPaNrLFtXNGCNpbxsFSxkwDzrTEKitdrzpwrZLOEOgwdkoQR2WroOGcd7RtHPCGbaM3675TipcL5FmPPlsYBhMgLllLSlrVKCGKfP2PPI9LCuVzWjKpiKKKFPR2jWyKOZeZ6Cn50aQbTbD-k4QuSei7JIp9tWm4dGWKD_J-9AXsbIDJ1gwumWB9_utYUVzy4vbW7soPcPP_F_XR_tn90_W6wucS1UOFSReaCyZa_f30WLMv3z6Sz0Jqwm4B5_OwYg</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Oberndorfer, Tyson A.</creator><creator>Kaye, Walter H.</creator><creator>Simmons, Alan N.</creator><creator>Strigo, Irina A.</creator><creator>Matthews, Scott C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women</title><author>Oberndorfer, Tyson A. ; Kaye, Walter H. ; Simmons, Alan N. ; Strigo, Irina A. ; Matthews, Scott C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4850-ffa772dc36ec233a4efa51c9c8fd9bef598fa1eb00f971f2859e4666b254fe643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anorexia</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - physiopathology</topic><topic>Anorexia Nervosa - rehabilitation</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - physiopathology</topic><topic>Eating behavior disorders</topic><topic>Eating disorders</topic><topic>Female</topic><topic>fMRI</topic><topic>Humans</topic><topic>inhibition</topic><topic>Inhibition (Psychology)</topic><topic>Medical sciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>prefrontal cortex</topic><topic>Prefrontal Cortex - physiology</topic><topic>Psychobiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>stop task</topic><topic>Task Performance and Analysis</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oberndorfer, Tyson A.</creatorcontrib><creatorcontrib>Kaye, Walter H.</creatorcontrib><creatorcontrib>Simmons, Alan N.</creatorcontrib><creatorcontrib>Strigo, Irina A.</creatorcontrib><creatorcontrib>Matthews, Scott C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of eating disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oberndorfer, Tyson A.</au><au>Kaye, Walter H.</au><au>Simmons, Alan N.</au><au>Strigo, Irina A.</au><au>Matthews, Scott C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women</atitle><jtitle>The International journal of eating disorders</jtitle><addtitle>Int. J. Eat. Disord</addtitle><date>2011-01</date><risdate>2011</risdate><volume>44</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0276-3478</issn><eissn>1098-108X</eissn><coden>INDIDJ</coden><abstract>Objective:
It is well known that individuals with anorexia nervosa (AN) are inhibited and over‐controlled. This study investigated a prefrontal‐cingulate network that is involved in inhibitory control.
Method:
To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during functional magnetic resonance imaging.
Results:
Consistent with the a priori hypothesis, RAN subjects showed altered task‐related activation in the medial prefrontal cortex (mPFC), a critical node of the inhibitory control network. Specifically, whereas RAN and CW showed similar mPFC acitivity during trials when inhibitory demand was low (i.e., easy trials), RAN relative to CW showed significantly less mPFC activation as inhibition trials became more difficult (i.e., hard trials), suggesting a demand‐specific modulation of inhibitory control circuitry in RAN.
Discussion:
These findings support a neural basis for altered impulse control symptoms in AN © © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:1–8)</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20127942</pmid><doi>10.1002/eat.20750</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Adult and adolescent clinical studies Anorexia Anorexia nervosa Anorexia Nervosa - physiopathology Anorexia Nervosa - rehabilitation Biological and medical sciences Brain Disruptive, Impulse Control, and Conduct Disorders - physiopathology Eating behavior disorders Eating disorders Female fMRI Humans inhibition Inhibition (Psychology) Medical sciences NMR Nuclear magnetic resonance prefrontal cortex Prefrontal Cortex - physiology Psychobiology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry stop task Task Performance and Analysis Women Young Adult |
| title | Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women |
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