Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo
Curcuma zedoaria (Berg.) Rosc., a traditional Chinese herb, was used widely but absolutely prohibited for the pregnant in clinic. Based on that there is abundant angiogenesis in endometrium and placenta during gestation period, we hypothesized that some components from it could inhibit angiogenesis...
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| description | Curcuma zedoaria (Berg.) Rosc., a traditional Chinese herb, was used widely but absolutely prohibited for the pregnant in clinic. Based on that there is abundant angiogenesis in endometrium and placenta during gestation period, we hypothesized that some components from it could inhibit angiogenesis and then damaged the supply of oxygen and nutrition to the embryo, which finally led to gestation failure.
This study was set to demonstrate whether essential oil, major components of
Curcuma zedoaria had anti-angiogenic effect.
Essential oil of
Curcuma zedoaria (EO-CZ) was abstracted by steam distillation extraction. Cell proliferation assay and two angiogenic models, rat aortic ring assay and chick embryo chorioallantoic membrane assay were presented. Furthermore, melanoma growth and experimental lung metastasis assay in mice were performed to evaluate its anti-angiogenesis effect
in vivo. Immunohistochemical analysis and enzyme-linked immunosorbent assay (ELISA) were used to respectively detect the expression of CD34 and matrix metalloproteinases (MMPs).
EO-CZ exhibited anti-proliferative effect on B16BL6 and SMMC-7721 cells, the IC
50, respectively was 41.8
μg/ml and 30.7
μg/ml, and on HUVEC (Human Umbilical Vein Endothelial Cells) cells with IC
50 of far more than 120
μg/ml. Both 20
μg/ml and 40
μg/ml EO-CZ indicated significant suppression on sprouting vessels of aortic ring and formation of microvessels in chick embryo chorioallantoic membrane
in vitro. Moreover, solid melanoma grown in left oxter of mice was obviously inhibited after oral intake of 100 and 200
mg/kg of EO-CZ a day for 28 days, and CD34 expression indicating angiogenesis in melanoma reduced significantly compared with control; melanoma metastatic nodules in lung were detected to be inhibited, as well as MMP-2 and MMP-9 expression in serum.
Essential oil, a fat-soluble fraction of
Curcuma zedoaria, presented anti-angiogenic activity
in vitro and
in vivo, resulting in suppressing melanoma growth and lung metastasis. And this was associated with down-regulating MMPs. |
| doi_str_mv | 10.1016/j.jep.2010.09.031 |
| format | Article |
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This study was set to demonstrate whether essential oil, major components of
Curcuma zedoaria had anti-angiogenic effect.
Essential oil of
Curcuma zedoaria (EO-CZ) was abstracted by steam distillation extraction. Cell proliferation assay and two angiogenic models, rat aortic ring assay and chick embryo chorioallantoic membrane assay were presented. Furthermore, melanoma growth and experimental lung metastasis assay in mice were performed to evaluate its anti-angiogenesis effect
in vivo. Immunohistochemical analysis and enzyme-linked immunosorbent assay (ELISA) were used to respectively detect the expression of CD34 and matrix metalloproteinases (MMPs).
EO-CZ exhibited anti-proliferative effect on B16BL6 and SMMC-7721 cells, the IC
50, respectively was 41.8
μg/ml and 30.7
μg/ml, and on HUVEC (Human Umbilical Vein Endothelial Cells) cells with IC
50 of far more than 120
μg/ml. Both 20
μg/ml and 40
μg/ml EO-CZ indicated significant suppression on sprouting vessels of aortic ring and formation of microvessels in chick embryo chorioallantoic membrane
in vitro. Moreover, solid melanoma grown in left oxter of mice was obviously inhibited after oral intake of 100 and 200
mg/kg of EO-CZ a day for 28 days, and CD34 expression indicating angiogenesis in melanoma reduced significantly compared with control; melanoma metastatic nodules in lung were detected to be inhibited, as well as MMP-2 and MMP-9 expression in serum.
Essential oil, a fat-soluble fraction of
Curcuma zedoaria, presented anti-angiogenic activity
in vitro and
in vivo, resulting in suppressing melanoma growth and lung metastasis. And this was associated with down-regulating MMPs.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2010.09.031</identifier><identifier>PMID: 20920565</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>angiogenesis ; Angiogenesis Inhibitors - pharmacology ; animal models ; Animals ; Anti-angiogenesis ; anti-angiogenesis properties ; Aorta, Thoracic - drug effects ; Biological and medical sciences ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; cell proliferation ; Cell Proliferation - drug effects ; Cells, Cultured ; Chick Embryo ; chickens ; chicks ; Chorioallantoic Membrane - drug effects ; Curcuma ; Curcuma zedoaria ; Curcuma zeodaria ; endometrium ; Endothelial Cells ; Essential oil ; essential oils ; gene expression ; General pharmacology ; herbal medicines ; Humans ; immunohistochemistry ; In Vitro Techniques ; in vivo studies ; inhibitory concentration 50 ; Liver Neoplasms ; Lung Neoplasms - secondary ; Male ; Matrix metalloproteins ; Medical sciences ; medicinal plants ; medicinal properties ; melanoma ; Melanoma growth ; Melanoma, Experimental - blood supply ; Melanoma, Experimental - pathology ; metalloproteinases ; Metastasis ; Mice ; Neovascularization, Pathologic - drug therapy ; Neovascularization, Physiologic - drug effects ; Oils, Volatile - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; Phytotherapy ; placenta ; Plant Extracts - pharmacology ; Rats ; Rhizome ; tissue culture</subject><ispartof>Journal of ethnopharmacology, 2011-01, Vol.133 (1), p.220-226</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-87a008449893d6fa2ee57e0dae7d5027c1b14b8191d4df92c5b2678a0dba6c873</citedby><cites>FETCH-LOGICAL-c406t-87a008449893d6fa2ee57e0dae7d5027c1b14b8191d4df92c5b2678a0dba6c873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2010.09.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23817505$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20920565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wenxing</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><creatorcontrib>Gao, Ming</creatorcontrib><creatorcontrib>Wu, Jiaming</creatorcontrib><creatorcontrib>Wang, Aiyun</creatorcontrib><creatorcontrib>Shi, Ronghuo</creatorcontrib><title>Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Curcuma zedoaria (Berg.) Rosc., a traditional Chinese herb, was used widely but absolutely prohibited for the pregnant in clinic. Based on that there is abundant angiogenesis in endometrium and placenta during gestation period, we hypothesized that some components from it could inhibit angiogenesis and then damaged the supply of oxygen and nutrition to the embryo, which finally led to gestation failure.
This study was set to demonstrate whether essential oil, major components of
Curcuma zedoaria had anti-angiogenic effect.
Essential oil of
Curcuma zedoaria (EO-CZ) was abstracted by steam distillation extraction. Cell proliferation assay and two angiogenic models, rat aortic ring assay and chick embryo chorioallantoic membrane assay were presented. Furthermore, melanoma growth and experimental lung metastasis assay in mice were performed to evaluate its anti-angiogenesis effect
in vivo. Immunohistochemical analysis and enzyme-linked immunosorbent assay (ELISA) were used to respectively detect the expression of CD34 and matrix metalloproteinases (MMPs).
EO-CZ exhibited anti-proliferative effect on B16BL6 and SMMC-7721 cells, the IC
50, respectively was 41.8
μg/ml and 30.7
μg/ml, and on HUVEC (Human Umbilical Vein Endothelial Cells) cells with IC
50 of far more than 120
μg/ml. Both 20
μg/ml and 40
μg/ml EO-CZ indicated significant suppression on sprouting vessels of aortic ring and formation of microvessels in chick embryo chorioallantoic membrane
in vitro. Moreover, solid melanoma grown in left oxter of mice was obviously inhibited after oral intake of 100 and 200
mg/kg of EO-CZ a day for 28 days, and CD34 expression indicating angiogenesis in melanoma reduced significantly compared with control; melanoma metastatic nodules in lung were detected to be inhibited, as well as MMP-2 and MMP-9 expression in serum.
Essential oil, a fat-soluble fraction of
Curcuma zedoaria, presented anti-angiogenic activity
in vitro and
in vivo, resulting in suppressing melanoma growth and lung metastasis. And this was associated with down-regulating MMPs.</description><subject>angiogenesis</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>animal models</subject><subject>Animals</subject><subject>Anti-angiogenesis</subject><subject>anti-angiogenesis properties</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>chickens</subject><subject>chicks</subject><subject>Chorioallantoic Membrane - drug effects</subject><subject>Curcuma</subject><subject>Curcuma zedoaria</subject><subject>Curcuma zeodaria</subject><subject>endometrium</subject><subject>Endothelial Cells</subject><subject>Essential oil</subject><subject>essential oils</subject><subject>gene expression</subject><subject>General pharmacology</subject><subject>herbal medicines</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>In Vitro Techniques</subject><subject>in vivo studies</subject><subject>inhibitory concentration 50</subject><subject>Liver Neoplasms</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Matrix metalloproteins</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>melanoma</subject><subject>Melanoma growth</subject><subject>Melanoma, Experimental - blood supply</subject><subject>Melanoma, Experimental - pathology</subject><subject>metalloproteinases</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Oils, Volatile - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>Phytotherapy</subject><subject>placenta</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rhizome</subject><subject>tissue culture</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EotvCD-ACvqCesoydDzviVK34kipxoD1bE3uy8iqJFztZqfx6vMoCN07WyM_MvHqGsTcCtgJE8-GwPdBxKyHX0G6hFM_YRmglC1Wr8jnbQKl0oVUlrth1SgcAUKKCl-xKQiuhbuoNe7ibZl_gtPdhTxMlnzj1PdmZh55TSpS_ceDBD7yPYeS7JdplRP6LXMDokfuJn_wcA8fJrcUpvGIvehwSvb68N-zx86eH3dfi_vuXb7u7-8JW0Mw5GQLoqmp1W7qmR0lUKwKHpFwNUlnRiarTohWucn0rbd3JRmkE12FjtSpv2O069xjDz4XSbEafLA0DThSWZLQUldYliEyKlbQxpBSpN8foR4xPRoA5uzQHk12as0sDrckuc8_by_SlG8n97fgjLwPvLwAmi0MfcbI-_eNKLVQNZ-7dyvUYDO5jZh5_5E05WCtL2ehMfFwJyrZOnqJJ1tNkyfmYb2Fc8P8J-htpzJoj</recordid><startdate>20110107</startdate><enddate>20110107</enddate><creator>Chen, Wenxing</creator><creator>Lu, Yin</creator><creator>Gao, Ming</creator><creator>Wu, Jiaming</creator><creator>Wang, Aiyun</creator><creator>Shi, Ronghuo</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110107</creationdate><title>Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo</title><author>Chen, Wenxing ; Lu, Yin ; Gao, Ming ; Wu, Jiaming ; Wang, Aiyun ; Shi, Ronghuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-87a008449893d6fa2ee57e0dae7d5027c1b14b8191d4df92c5b2678a0dba6c873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>angiogenesis</topic><topic>Angiogenesis Inhibitors - pharmacology</topic><topic>animal models</topic><topic>Animals</topic><topic>Anti-angiogenesis</topic><topic>anti-angiogenesis properties</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Chick Embryo</topic><topic>chickens</topic><topic>chicks</topic><topic>Chorioallantoic Membrane - drug effects</topic><topic>Curcuma</topic><topic>Curcuma zedoaria</topic><topic>Curcuma zeodaria</topic><topic>endometrium</topic><topic>Endothelial Cells</topic><topic>Essential oil</topic><topic>essential oils</topic><topic>gene expression</topic><topic>General pharmacology</topic><topic>herbal medicines</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>In Vitro Techniques</topic><topic>in vivo studies</topic><topic>inhibitory concentration 50</topic><topic>Liver Neoplasms</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Matrix metalloproteins</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>melanoma</topic><topic>Melanoma growth</topic><topic>Melanoma, Experimental - blood supply</topic><topic>Melanoma, Experimental - pathology</topic><topic>metalloproteinases</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Oils, Volatile - pharmacology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>Phytotherapy</topic><topic>placenta</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rhizome</topic><topic>tissue culture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wenxing</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><creatorcontrib>Gao, Ming</creatorcontrib><creatorcontrib>Wu, Jiaming</creatorcontrib><creatorcontrib>Wang, Aiyun</creatorcontrib><creatorcontrib>Shi, Ronghuo</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wenxing</au><au>Lu, Yin</au><au>Gao, Ming</au><au>Wu, Jiaming</au><au>Wang, Aiyun</au><au>Shi, Ronghuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2011-01-07</date><risdate>2011</risdate><volume>133</volume><issue>1</issue><spage>220</spage><epage>226</epage><pages>220-226</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Curcuma zedoaria (Berg.) Rosc., a traditional Chinese herb, was used widely but absolutely prohibited for the pregnant in clinic. Based on that there is abundant angiogenesis in endometrium and placenta during gestation period, we hypothesized that some components from it could inhibit angiogenesis and then damaged the supply of oxygen and nutrition to the embryo, which finally led to gestation failure.
This study was set to demonstrate whether essential oil, major components of
Curcuma zedoaria had anti-angiogenic effect.
Essential oil of
Curcuma zedoaria (EO-CZ) was abstracted by steam distillation extraction. Cell proliferation assay and two angiogenic models, rat aortic ring assay and chick embryo chorioallantoic membrane assay were presented. Furthermore, melanoma growth and experimental lung metastasis assay in mice were performed to evaluate its anti-angiogenesis effect
in vivo. Immunohistochemical analysis and enzyme-linked immunosorbent assay (ELISA) were used to respectively detect the expression of CD34 and matrix metalloproteinases (MMPs).
EO-CZ exhibited anti-proliferative effect on B16BL6 and SMMC-7721 cells, the IC
50, respectively was 41.8
μg/ml and 30.7
μg/ml, and on HUVEC (Human Umbilical Vein Endothelial Cells) cells with IC
50 of far more than 120
μg/ml. Both 20
μg/ml and 40
μg/ml EO-CZ indicated significant suppression on sprouting vessels of aortic ring and formation of microvessels in chick embryo chorioallantoic membrane
in vitro. Moreover, solid melanoma grown in left oxter of mice was obviously inhibited after oral intake of 100 and 200
mg/kg of EO-CZ a day for 28 days, and CD34 expression indicating angiogenesis in melanoma reduced significantly compared with control; melanoma metastatic nodules in lung were detected to be inhibited, as well as MMP-2 and MMP-9 expression in serum.
Essential oil, a fat-soluble fraction of
Curcuma zedoaria, presented anti-angiogenic activity
in vitro and
in vivo, resulting in suppressing melanoma growth and lung metastasis. And this was associated with down-regulating MMPs.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20920565</pmid><doi>10.1016/j.jep.2010.09.031</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of ethnopharmacology, 2011-01, Vol.133 (1), p.220-226 |
| issn | 0378-8741 1872-7573 |
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| subjects | angiogenesis Angiogenesis Inhibitors - pharmacology animal models Animals Anti-angiogenesis anti-angiogenesis properties Aorta, Thoracic - drug effects Biological and medical sciences Carcinoma, Hepatocellular - pathology Cell Line, Tumor cell proliferation Cell Proliferation - drug effects Cells, Cultured Chick Embryo chickens chicks Chorioallantoic Membrane - drug effects Curcuma Curcuma zedoaria Curcuma zeodaria endometrium Endothelial Cells Essential oil essential oils gene expression General pharmacology herbal medicines Humans immunohistochemistry In Vitro Techniques in vivo studies inhibitory concentration 50 Liver Neoplasms Lung Neoplasms - secondary Male Matrix metalloproteins Medical sciences medicinal plants medicinal properties melanoma Melanoma growth Melanoma, Experimental - blood supply Melanoma, Experimental - pathology metalloproteinases Metastasis Mice Neovascularization, Pathologic - drug therapy Neovascularization, Physiologic - drug effects Oils, Volatile - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy placenta Plant Extracts - pharmacology Rats Rhizome tissue culture |
| title | Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo |
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