Success in sentinel lymph node procedures in obese patients with breast cancer
Abstract Background Sentinel lymph node (SLN) biopsy for axillary staging in breast cancer is technically more demanding but of added benefit in obese patients. This retrospective review compares variables and outcomes of SLN staging in obese and nonobese women. Methods From 235 total SLN cases, dem...
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| Veröffentlicht in: | The American journal of surgery 2010-12, Vol.200 (6), p.707-711 |
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| creator | Gawlick, Ute, M.D., Ph.D Mone, Mary C., R.N., B.S.E Nelson, Edward T., B.A Hansen, Heidi J Nelson, Edward W., M.D |
| description | Abstract Background Sentinel lymph node (SLN) biopsy for axillary staging in breast cancer is technically more demanding but of added benefit in obese patients. This retrospective review compares variables and outcomes of SLN staging in obese and nonobese women. Methods From 235 total SLN cases, demographics and clinical and procedural variables were collected and compared in obese (body mass index [BMI] of ≥35, n = 28) and nonobese (BMI ≤25 [n = 84]) patients. Results Overall, the intraoperative false-negative rate was 13.6% and failure to identify SLN occurred in 2 cases (.85%). Although no differences in patient or tumor characteristics were found, obese patients had significantly lower external hotspot counts, first sentinel node counts, and fewer sentinel nodes recovered when compared with the nonobese. Conclusions SLN procedures are successful and accurate for axillary staging in obese women and avoid the added morbidity of axillary lymph node dissection in this higher risk population. |
| doi_str_mv | 10.1016/j.amjsurg.2010.07.031 |
| format | Article |
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This retrospective review compares variables and outcomes of SLN staging in obese and nonobese women. Methods From 235 total SLN cases, demographics and clinical and procedural variables were collected and compared in obese (body mass index [BMI] of ≥35, n = 28) and nonobese (BMI ≤25 [n = 84]) patients. Results Overall, the intraoperative false-negative rate was 13.6% and failure to identify SLN occurred in 2 cases (.85%). Although no differences in patient or tumor characteristics were found, obese patients had significantly lower external hotspot counts, first sentinel node counts, and fewer sentinel nodes recovered when compared with the nonobese. Conclusions SLN procedures are successful and accurate for axillary staging in obese women and avoid the added morbidity of axillary lymph node dissection in this higher risk population.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2010.07.031</identifier><identifier>PMID: 21146008</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Axilla ; Biological and medical sciences ; Biopsy ; Body mass ; Body mass index ; Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - pathology ; Cancer ; Chemotherapy ; Demographic variables ; Demographics ; Demography ; Dissection ; Epidemics ; False Negative Reactions ; Female ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Identification ; Lymph ; Lymph Node Excision ; Lymph nodes ; Lymphatic system ; Lymphedema ; Mammary gland diseases ; Medical prognosis ; Medical sciences ; Metabolic diseases ; Middle Aged ; Morbidity ; Nodes ; Obesity ; Obesity - complications ; Patients ; Sentinel Lymph Node Biopsy ; Success ; Sulfur ; Surgeons ; Surgery ; Trends ; Tumors ; Variables</subject><ispartof>The American journal of surgery, 2010-12, Vol.200 (6), p.707-711</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 1, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-9444d22e9b75104e7969e6ed4d174a0182599d61c2ca82bd43c694d20d19fb8d3</citedby><cites>FETCH-LOGICAL-c477t-9444d22e9b75104e7969e6ed4d174a0182599d61c2ca82bd43c694d20d19fb8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961010005556$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23752362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21146008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gawlick, Ute, M.D., Ph.D</creatorcontrib><creatorcontrib>Mone, Mary C., R.N., B.S.E</creatorcontrib><creatorcontrib>Nelson, Edward T., B.A</creatorcontrib><creatorcontrib>Hansen, Heidi J</creatorcontrib><creatorcontrib>Nelson, Edward W., M.D</creatorcontrib><title>Success in sentinel lymph node procedures in obese patients with breast cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Sentinel lymph node (SLN) biopsy for axillary staging in breast cancer is technically more demanding but of added benefit in obese patients. This retrospective review compares variables and outcomes of SLN staging in obese and nonobese women. Methods From 235 total SLN cases, demographics and clinical and procedural variables were collected and compared in obese (body mass index [BMI] of ≥35, n = 28) and nonobese (BMI ≤25 [n = 84]) patients. Results Overall, the intraoperative false-negative rate was 13.6% and failure to identify SLN occurred in 2 cases (.85%). Although no differences in patient or tumor characteristics were found, obese patients had significantly lower external hotspot counts, first sentinel node counts, and fewer sentinel nodes recovered when compared with the nonobese. Conclusions SLN procedures are successful and accurate for axillary staging in obese women and avoid the added morbidity of axillary lymph node dissection in this higher risk population.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Axilla</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Demographic variables</subject><subject>Demographics</subject><subject>Demography</subject><subject>Dissection</subject><subject>Epidemics</subject><subject>False Negative Reactions</subject><subject>Female</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Identification</subject><subject>Lymph</subject><subject>Lymph Node Excision</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphedema</subject><subject>Mammary gland diseases</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Nodes</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Patients</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Success</subject><subject>Sulfur</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Trends</subject><subject>Tumors</subject><subject>Variables</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkkuP1DAMgCMEYoeFnwCqhBCnDnGaJs2FFVrxklZwWDhHaeJhU_oY4hY0_56UGVhpL5ycWJ8d55MZewp8CxzUq27rho6W9G0reM5xveUV3GMbaLQpoWmq-2zDORelUcDP2COiLl8BZPWQnYkcFefNhn26XrxHoiKOBeE4xxH7oj8M-5tinAIW-zR5DEvCP8TUIuWcm2NGqfgV55uiTehoLrwbPabH7MHO9YRPTvGcfX339svlh_Lq8_uPl2-uSi-1nksjpQxCoGl1DVyiNsqgwiADaOk4NKI2JijwwrtGtEFWXplcwQOYXduE6py9PPbN8_1YkGY7RPLY927EaSHbCJBNLbTI5PM7ZDctaczDWTCiBgPKmEzVR8qniSjhzu5THFw6WOB29W07e_JtV9-Wa5t957pnp-5LO2D4V_VXcAZenABH3vW7lDVFuuUqXYtKrWNeHDnM1n5GTJZ8lpzdx4R-tmGK_x3l9Z0Ovo9jzI9-xwPS7a8tCcvt9boc625APtR1rarfLhi0Rw</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Gawlick, Ute, M.D., Ph.D</creator><creator>Mone, Mary C., R.N., B.S.E</creator><creator>Nelson, Edward T., B.A</creator><creator>Hansen, Heidi J</creator><creator>Nelson, Edward W., M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Success in sentinel lymph node procedures in obese patients with breast cancer</title><author>Gawlick, Ute, M.D., Ph.D ; Mone, Mary C., R.N., B.S.E ; Nelson, Edward T., B.A ; Hansen, Heidi J ; Nelson, Edward W., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-9444d22e9b75104e7969e6ed4d174a0182599d61c2ca82bd43c694d20d19fb8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Axilla</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Demographic variables</topic><topic>Demographics</topic><topic>Demography</topic><topic>Dissection</topic><topic>Epidemics</topic><topic>False Negative Reactions</topic><topic>Female</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Identification</topic><topic>Lymph</topic><topic>Lymph Node Excision</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Lymphedema</topic><topic>Mammary gland diseases</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Nodes</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Patients</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Success</topic><topic>Sulfur</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Trends</topic><topic>Tumors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gawlick, Ute, M.D., Ph.D</creatorcontrib><creatorcontrib>Mone, Mary C., R.N., B.S.E</creatorcontrib><creatorcontrib>Nelson, Edward T., B.A</creatorcontrib><creatorcontrib>Hansen, Heidi J</creatorcontrib><creatorcontrib>Nelson, Edward W., M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gawlick, Ute, M.D., Ph.D</au><au>Mone, Mary C., R.N., B.S.E</au><au>Nelson, Edward T., B.A</au><au>Hansen, Heidi J</au><au>Nelson, Edward W., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Success in sentinel lymph node procedures in obese patients with breast cancer</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>200</volume><issue>6</issue><spage>707</spage><epage>711</epage><pages>707-711</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Abstract Background Sentinel lymph node (SLN) biopsy for axillary staging in breast cancer is technically more demanding but of added benefit in obese patients. This retrospective review compares variables and outcomes of SLN staging in obese and nonobese women. Methods From 235 total SLN cases, demographics and clinical and procedural variables were collected and compared in obese (body mass index [BMI] of ≥35, n = 28) and nonobese (BMI ≤25 [n = 84]) patients. Results Overall, the intraoperative false-negative rate was 13.6% and failure to identify SLN occurred in 2 cases (.85%). Although no differences in patient or tumor characteristics were found, obese patients had significantly lower external hotspot counts, first sentinel node counts, and fewer sentinel nodes recovered when compared with the nonobese. Conclusions SLN procedures are successful and accurate for axillary staging in obese women and avoid the added morbidity of axillary lymph node dissection in this higher risk population.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21146008</pmid><doi>10.1016/j.amjsurg.2010.07.031</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Axilla Biological and medical sciences Biopsy Body mass Body mass index Breast cancer Breast Neoplasms - complications Breast Neoplasms - pathology Cancer Chemotherapy Demographic variables Demographics Demography Dissection Epidemics False Negative Reactions Female General aspects Gynecology. Andrology. Obstetrics Humans Identification Lymph Lymph Node Excision Lymph nodes Lymphatic system Lymphedema Mammary gland diseases Medical prognosis Medical sciences Metabolic diseases Middle Aged Morbidity Nodes Obesity Obesity - complications Patients Sentinel Lymph Node Biopsy Success Sulfur Surgeons Surgery Trends Tumors Variables |
| title | Success in sentinel lymph node procedures in obese patients with breast cancer |
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