Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: A case series

Background: Antitumor necrosis factor alpha (aTNF) therapies are commonly used in the treatment of pediatric inflammatory bowel disease (IBD). However, inhibition of the TNF‐alpha pathway predisposes to serious infections, including histoplasmosis, which is the most common invasive fungal infection...

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Veröffentlicht in:	Inflammatory bowel diseases 2011-01, Vol.17 (1), p.56-61
Hauptverfasser:	Dotson, Jennifer L., Crandall, Wallace, Mousa, Hayat, Honegger, Jonathan R., Denson, Lee, Samson, Charles, Cunningham, Dennis, Balint, Jane, Dienhart, Molly, Jaggi, Preeti, Carvalho, Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Adolescent Adult Anti-Inflammatory Agents - therapeutic use Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antifungal Agents - therapeutic use antitumor necrosis factor alpha therapy Children Data processing Endemic Diseases Female Fungemia - diagnosis Fungemia - drug therapy Fungemia - microbiology histoplasma Histoplasma - pathogenicity Histoplasma capsulatum Histoplasmosis Histoplasmosis - diagnosis Histoplasmosis - drug therapy Histoplasmosis - microbiology Humans Infection Infectious diseases inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - microbiology Inflammatory Bowel Diseases - pathology Infliximab Intestine Lung Lung Diseases, Fungal - diagnosis Lung Diseases, Fungal - drug therapy Lung Diseases, Fungal - microbiology Male Mortality Necrosis pediatric Pediatrics Tomography, X-Ray Computed Treatment Outcome Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - antagonists & inhibitors Young Adult
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