Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment. In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modi...

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Veröffentlicht in:	European journal of pharmacology 2011-01, Vol.650 (2), p.688-693
Hauptverfasser:	Porter, David W., Irwin, Nigel, Flatt, Peter R., Hölscher, Christian, Gault, Victor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals Biological and medical sciences Blood Glucose - metabolism Body weight Brain cognition Cognition Disorders - drug therapy Cognition Disorders - physiopathology Cognitive ability Cognitive function Diabetes mellitus Dietary Fats - administration & dosage Feeding Food intake Gastric Inhibitory Polypeptide - administration & dosage Gastric Inhibitory Polypeptide - pharmacology gastric inhibitory polypeptide receptors GIP protein glucose Glucose homeostasis Glucose Intolerance - metabolism Glucose tolerance Glucose-dependent insulinotropic polypeptide (GIP) glycemic control High fat diet High-fat feeding Hippocampus Hippocampus - drug effects Hippocampus - physiopathology Homeostasis Insulin Insulin - blood Insulin - metabolism Insulin Resistance - physiology Long-term potentiation Long-Term Potentiation - drug effects Male Medical sciences Mice Neurotransmission noninsulin-dependent diabetes mellitus nutritional intervention Obesity - blood Obesity - drug therapy Obesity - metabolism pharmacology Pharmacology. Drug treatments Plasticity (synaptic) polypeptides Receptor mechanisms Receptors, Gastrointestinal Hormone - agonists
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