A Click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates

An efficient protocol was developed to tether chelating agents and rhenium complexes onto a glucoside scaffold with a heterogeneous copper catalyst via click chemistry. The supported catalyst avoids the formation of unwanted copper complexes during the cyclisation step. The possibility to graft a pr...

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Veröffentlicht in:	Carbohydrate research 2011-01, Vol.346 (1), p.26-34
Hauptverfasser:	Benoist, Eric, Coulais, Yvon, Almant, Mehdi, Kovensky, José, Moreau, Vincent, Lesur, David, Artigau, Marine, Picard, Claude, Galaup, Chantal, Gouin, Sébastien G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconjugation Chelating Agents - chemistry Click Chemistry - methods Copper - chemistry Glucose - chemistry Glycoconjugates Glycoconjugates - chemical synthesis Glycoconjugates - chemistry Heterogeneous click chemistry Metal complexes Molecular Structure Organotechnetium Compounds - chemical synthesis Organotechnetium Compounds - chemistry Rhenium - chemistry Technetium - chemistry
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