Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

Background: High antibody reactivity toward microbial antigens in Crohn's disease (CD) patients is predictive of a more aggressive disease course. However, few ulcerative colitis (UC) patients exhibit serologic reactivity toward microbial antigens. Mucosal expression of IFN‐γ plays a pivotal ro...

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Veröffentlicht in:	Inflammatory bowel diseases 2011-01, Vol.17 (1), p.171-178
Hauptverfasser:	Gonsky, Rivkah, Deem, Richard L., Landers, Carol J., Derkowski, Carrie A., Berel, Dror, McGovern, Dermot P.B., Targan, Stephan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over alpha -Interferon Antibodies Antibodies, Antineutrophil Cytoplasmic - metabolism Antigens, Bacterial - immunology Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - metabolism Crohn Disease - genetics Crohn Disease - immunology Crohn Disease - metabolism Crohn's disease Cytokines Data processing DNA Methylation Enzyme-Linked Immunosorbent Assay epigenetics Female Helper cells human Humans IBD Immune response Inflammatory bowel diseases Interferon Interferon-gamma - genetics Interferon-gamma - secretion Intestine Lymphocytes T Male Methylation Middle Aged Mucosa Promoter Regions, Genetic - genetics Surgery T Lymphocytes Ulcerative colitis Young Adult
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