Responses of plasma glucose, free fatty acids and glucagon to cobalt and nickel chlorides by Gallus domesticus
1. 1. Hyperglycaemia developed inconsistently following treatment of the fed or starved fowl with cobalt chloride. The concentration of plasma free fatty acids (FFA) increased in fed birds but fell in starved birds. 2. 2. Cobalt chloride caused a significant increase in glucagon-like immunoreactive...
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| Veröffentlicht in: | Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1973-11, Vol.46 (3), p.427-436 |
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| container_end_page | 436 |
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| container_issue | 3 |
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| container_title | Comparative biochemistry and physiology. A, Comparative physiology |
| container_volume | 46 |
| creator | Freeman, B.M Langslow, D.R |
| description | 1.
1. Hyperglycaemia developed inconsistently following treatment of the fed or starved fowl with cobalt chloride. The concentration of plasma free fatty acids (FFA) increased in fed birds but fell in starved birds.
2.
2. Cobalt chloride caused a significant increase in glucagon-like immunoreactive plasma only in the fully fed bird.
3.
3. Nickel chloride stimulated hyperglycaemia which was transient in fed birds but prolonged in starved birds. There was a concomitant fall in the plasma FFA of the former, and no change in the latter.
4.
4. It is concluded that the efficacy of cobalt and nickel in stimulating the release of pancreatic glucagon is doubtful. |
| doi_str_mv | 10.1016/0300-9629(73)90093-5 |
| format | Article |
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1. Hyperglycaemia developed inconsistently following treatment of the fed or starved fowl with cobalt chloride. The concentration of plasma free fatty acids (FFA) increased in fed birds but fell in starved birds.
2.
2. Cobalt chloride caused a significant increase in glucagon-like immunoreactive plasma only in the fully fed bird.
3.
3. Nickel chloride stimulated hyperglycaemia which was transient in fed birds but prolonged in starved birds. There was a concomitant fall in the plasma FFA of the former, and no change in the latter.
4.
4. It is concluded that the efficacy of cobalt and nickel in stimulating the release of pancreatic glucagon is doubtful.</description><identifier>ISSN: 0300-9629</identifier><identifier>DOI: 10.1016/0300-9629(73)90093-5</identifier><identifier>PMID: 4148979</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Blood Glucose - metabolism ; catecholamines ; Chickens ; Chlorides - pharmacology ; Cobalt - pharmacology ; cobalt chloride ; Depression, Chemical ; Fatty Acids, Nonesterified - blood ; Gallus domesticus ; Glucagon - blood ; Hematocrit ; Immunoassay ; Nickel - pharmacology ; nickel chloride ; pancreas ; plasma FFA ; Plasma glucose ; plasma immunoreactive glucagon ; Starvation ; Stimulation, Chemical</subject><ispartof>Comparative biochemistry and physiology. A, Comparative physiology, 1973-11, Vol.46 (3), p.427-436</ispartof><rights>1973</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-dd80d7597fd3fadd32188e4e1848207928f3477dfa5830e763ab0e0c4b0339843</citedby><cites>FETCH-LOGICAL-c357t-dd80d7597fd3fadd32188e4e1848207928f3477dfa5830e763ab0e0c4b0339843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4148979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freeman, B.M</creatorcontrib><creatorcontrib>Langslow, D.R</creatorcontrib><title>Responses of plasma glucose, free fatty acids and glucagon to cobalt and nickel chlorides by Gallus domesticus</title><title>Comparative biochemistry and physiology. A, Comparative physiology</title><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><description>1.
1. Hyperglycaemia developed inconsistently following treatment of the fed or starved fowl with cobalt chloride. The concentration of plasma free fatty acids (FFA) increased in fed birds but fell in starved birds.
2.
2. Cobalt chloride caused a significant increase in glucagon-like immunoreactive plasma only in the fully fed bird.
3.
3. Nickel chloride stimulated hyperglycaemia which was transient in fed birds but prolonged in starved birds. There was a concomitant fall in the plasma FFA of the former, and no change in the latter.
4.
4. It is concluded that the efficacy of cobalt and nickel in stimulating the release of pancreatic glucagon is doubtful.</description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>catecholamines</subject><subject>Chickens</subject><subject>Chlorides - pharmacology</subject><subject>Cobalt - pharmacology</subject><subject>cobalt chloride</subject><subject>Depression, Chemical</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Gallus domesticus</subject><subject>Glucagon - blood</subject><subject>Hematocrit</subject><subject>Immunoassay</subject><subject>Nickel - pharmacology</subject><subject>nickel chloride</subject><subject>pancreas</subject><subject>plasma FFA</subject><subject>Plasma glucose</subject><subject>plasma immunoreactive glucagon</subject><subject>Starvation</subject><subject>Stimulation, Chemical</subject><issn>0300-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9rFTEQxfOg1Nr6DRTyJBbcOtns3iQvQilahYIg-hyyyaRGs5trZrdwv717_9BHnwbmnDmH-TH2WsC1ALH5ABKgMZvWvFPyygAY2fTP2PnT-gV7SfQbAIQU_Rk760SnjTLnbPqOtC0TIfES-TY7Gh1_yIsvhO95rIg8unnecedTIO6mcFDdQ5n4XLgvg8vzYT0l_wcz979yqSmsecOO37mcF-KhjEhz8gtdsufRZcJXp3nBfn7-9OP2S3P_7e7r7c1942Wv5iYEDUH1RsUgowtBtkJr7FDoTregTKuj7JQK0fVaAqqNdAMg-G4AKY3u5AV7e8zd1vJ3WcvtmMhjzm7CspDVrZBK97Aau6PR10JUMdptTaOrOyvA7tHaPUO7Z2iVtAe0tl_P3pzyl2HE8HR04rrqH486rk8-JqyWfMLJY0gV_WxDSf8v-AevCYqz</recordid><startdate>19731101</startdate><enddate>19731101</enddate><creator>Freeman, B.M</creator><creator>Langslow, D.R</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19731101</creationdate><title>Responses of plasma glucose, free fatty acids and glucagon to cobalt and nickel chlorides by Gallus domesticus</title><author>Freeman, B.M ; Langslow, D.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-dd80d7597fd3fadd32188e4e1848207928f3477dfa5830e763ab0e0c4b0339843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>catecholamines</topic><topic>Chickens</topic><topic>Chlorides - pharmacology</topic><topic>Cobalt - pharmacology</topic><topic>cobalt chloride</topic><topic>Depression, Chemical</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Gallus domesticus</topic><topic>Glucagon - blood</topic><topic>Hematocrit</topic><topic>Immunoassay</topic><topic>Nickel - pharmacology</topic><topic>nickel chloride</topic><topic>pancreas</topic><topic>plasma FFA</topic><topic>Plasma glucose</topic><topic>plasma immunoreactive glucagon</topic><topic>Starvation</topic><topic>Stimulation, Chemical</topic><toplevel>online_resources</toplevel><creatorcontrib>Freeman, B.M</creatorcontrib><creatorcontrib>Langslow, D.R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freeman, B.M</au><au>Langslow, D.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responses of plasma glucose, free fatty acids and glucagon to cobalt and nickel chlorides by Gallus domesticus</atitle><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><date>1973-11-01</date><risdate>1973</risdate><volume>46</volume><issue>3</issue><spage>427</spage><epage>436</epage><pages>427-436</pages><issn>0300-9629</issn><abstract>1.
1. Hyperglycaemia developed inconsistently following treatment of the fed or starved fowl with cobalt chloride. The concentration of plasma free fatty acids (FFA) increased in fed birds but fell in starved birds.
2.
2. Cobalt chloride caused a significant increase in glucagon-like immunoreactive plasma only in the fully fed bird.
3.
3. Nickel chloride stimulated hyperglycaemia which was transient in fed birds but prolonged in starved birds. There was a concomitant fall in the plasma FFA of the former, and no change in the latter.
4.
4. It is concluded that the efficacy of cobalt and nickel in stimulating the release of pancreatic glucagon is doubtful.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>4148979</pmid><doi>10.1016/0300-9629(73)90093-5</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0300-9629 |
| ispartof | Comparative biochemistry and physiology. A, Comparative physiology, 1973-11, Vol.46 (3), p.427-436 |
| issn | 0300-9629 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Blood Glucose - metabolism catecholamines Chickens Chlorides - pharmacology Cobalt - pharmacology cobalt chloride Depression, Chemical Fatty Acids, Nonesterified - blood Gallus domesticus Glucagon - blood Hematocrit Immunoassay Nickel - pharmacology nickel chloride pancreas plasma FFA Plasma glucose plasma immunoreactive glucagon Starvation Stimulation, Chemical |
| title | Responses of plasma glucose, free fatty acids and glucagon to cobalt and nickel chlorides by Gallus domesticus |
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