Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse
An active substance, polypeptide in chemical nature, causing central stimulant activity in mice has been isolated from a sea anemone. Signs of central nervous stimulatory activity produced by this substance included fighting episodes, increased motor activity and clonic convulsions. The active subst...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 1973-12, Vol.24 (3), p.359-365 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 365 |
|---|---|
| container_issue | 3 |
| container_start_page | 359 |
| container_title | European journal of pharmacology |
| container_volume | 24 |
| creator | Turlapaty, P. Shibata, S. Norton, T.R. Kuchii, M. |
| description | An active substance, polypeptide in chemical nature, causing central stimulant activity in mice has been isolated from a sea anemone. Signs of central nervous stimulatory activity produced by this substance included fighting episodes, increased motor activity and clonic convulsions. The active substance produced significant decreases in brain norepinephrine concentration both at the ED
50 (6.4 mg/kg) and the maximum effective dose (9.3 mg/kg) during the stimulation period. Brain dopamine concentration was significantly decreased by the active substance at the ED
50 dose whereas brain serotonin concentration was not affected. The ED
50 dose of the active substance significantly inhibited the re-uptake of norepinephrine during the stimulation period and elevated hormetanephrine levels. These results suggest that the active substance causes central stimulation by releasing active norepinephrine from functional pools and inhibiting its re-uptake, thus making more norepinephrine available at a adrenoceptors. It is probable that brain dopamine plays a minor role in this stimulant action of the active substance. |
| doi_str_mv | 10.1016/0014-2999(73)90163-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82135531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014299973901635</els_id><sourcerecordid>82135531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-59d70c486adebc474d7fb9548e263c86389bddee5bf274f2a0d7e15b01d62c263</originalsourceid><addsrcrecordid>eNp9kEtLBSEUxyWKuj2-QYGrqMWUzug4boKIXhC0qNbi6JGsmbHUCfr2ebuXlq0E_49zzg-hQ0rOKKHtOSGUVbWU8kQ0p7L8NBXfQAvaCVkRQetNtPiz7KDdlN4IIVzWfBttM8q6jvEF-r52DkxOODissYEpRz3glP04D3rKOM19ynoygH0Kg85gsYthxPkVcAKN9QRjmAA_5eDNqzbZJ_xeWjwOE-6j9hMuetCjn-B3yDI4hjnBPtpyekhwsH730MvN9fPVXfXweHt_dflQmYaLXHFpBTGsa7WF3jDBrHC95KyDum1M1zad7K0F4L2rBXO1JlYA5T2htq1N8eyh41XvRwyfM6SsRp8MDOU8KHuorqYN5w0tRrYymhhSiuDUR_Sjjt-KErUkrpY41RKnEo36Ja54iR2t--d-BPsXWiMu-sVKh3Lkl4eokvFQiFofC3llg_9_wA--rJHp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82135531</pqid></control><display><type>article</type><title>Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Turlapaty, P. ; Shibata, S. ; Norton, T.R. ; Kuchii, M.</creator><creatorcontrib>Turlapaty, P. ; Shibata, S. ; Norton, T.R. ; Kuchii, M.</creatorcontrib><description>An active substance, polypeptide in chemical nature, causing central stimulant activity in mice has been isolated from a sea anemone. Signs of central nervous stimulatory activity produced by this substance included fighting episodes, increased motor activity and clonic convulsions. The active substance produced significant decreases in brain norepinephrine concentration both at the ED
50 (6.4 mg/kg) and the maximum effective dose (9.3 mg/kg) during the stimulation period. Brain dopamine concentration was significantly decreased by the active substance at the ED
50 dose whereas brain serotonin concentration was not affected. The ED
50 dose of the active substance significantly inhibited the re-uptake of norepinephrine during the stimulation period and elevated hormetanephrine levels. These results suggest that the active substance causes central stimulation by releasing active norepinephrine from functional pools and inhibiting its re-uptake, thus making more norepinephrine available at a adrenoceptors. It is probable that brain dopamine plays a minor role in this stimulant action of the active substance.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(73)90163-5</identifier><identifier>PMID: 4148845</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aggression - drug effects ; Animals ; Behavior, Animal - drug effects ; Brain Chemistry - drug effects ; Cerebral Cortex - metabolism ; Cnidaria ; Dopamine - analysis ; Dopamine content ; Humans ; Male ; Mice ; Motor Activity - drug effects ; Norepinephrine - analysis ; Norepinephrine - antagonists & inhibitors ; Norepinephrine content ; Norepinephrine uptake ; Normetanephrine - analysis ; Normetanephrine - metabolism ; Normetanephrine content ; Peptides - pharmacology ; Sea anemone ; Serotonin - analysis ; Serotonin Antagonists ; Time Factors ; Tissue Extracts - pharmacology ; Tritium</subject><ispartof>European journal of pharmacology, 1973-12, Vol.24 (3), p.359-365</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-59d70c486adebc474d7fb9548e263c86389bddee5bf274f2a0d7e15b01d62c263</citedby><cites>FETCH-LOGICAL-c357t-59d70c486adebc474d7fb9548e263c86389bddee5bf274f2a0d7e15b01d62c263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(73)90163-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4148845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turlapaty, P.</creatorcontrib><creatorcontrib>Shibata, S.</creatorcontrib><creatorcontrib>Norton, T.R.</creatorcontrib><creatorcontrib>Kuchii, M.</creatorcontrib><title>Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>An active substance, polypeptide in chemical nature, causing central stimulant activity in mice has been isolated from a sea anemone. Signs of central nervous stimulatory activity produced by this substance included fighting episodes, increased motor activity and clonic convulsions. The active substance produced significant decreases in brain norepinephrine concentration both at the ED
50 (6.4 mg/kg) and the maximum effective dose (9.3 mg/kg) during the stimulation period. Brain dopamine concentration was significantly decreased by the active substance at the ED
50 dose whereas brain serotonin concentration was not affected. The ED
50 dose of the active substance significantly inhibited the re-uptake of norepinephrine during the stimulation period and elevated hormetanephrine levels. These results suggest that the active substance causes central stimulation by releasing active norepinephrine from functional pools and inhibiting its re-uptake, thus making more norepinephrine available at a adrenoceptors. It is probable that brain dopamine plays a minor role in this stimulant action of the active substance.</description><subject>Aggression - drug effects</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cnidaria</subject><subject>Dopamine - analysis</subject><subject>Dopamine content</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Norepinephrine - analysis</subject><subject>Norepinephrine - antagonists & inhibitors</subject><subject>Norepinephrine content</subject><subject>Norepinephrine uptake</subject><subject>Normetanephrine - analysis</subject><subject>Normetanephrine - metabolism</subject><subject>Normetanephrine content</subject><subject>Peptides - pharmacology</subject><subject>Sea anemone</subject><subject>Serotonin - analysis</subject><subject>Serotonin Antagonists</subject><subject>Time Factors</subject><subject>Tissue Extracts - pharmacology</subject><subject>Tritium</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLBSEUxyWKuj2-QYGrqMWUzug4boKIXhC0qNbi6JGsmbHUCfr2ebuXlq0E_49zzg-hQ0rOKKHtOSGUVbWU8kQ0p7L8NBXfQAvaCVkRQetNtPiz7KDdlN4IIVzWfBttM8q6jvEF-r52DkxOODissYEpRz3glP04D3rKOM19ynoygH0Kg85gsYthxPkVcAKN9QRjmAA_5eDNqzbZJ_xeWjwOE-6j9hMuetCjn-B3yDI4hjnBPtpyekhwsH730MvN9fPVXfXweHt_dflQmYaLXHFpBTGsa7WF3jDBrHC95KyDum1M1zad7K0F4L2rBXO1JlYA5T2htq1N8eyh41XvRwyfM6SsRp8MDOU8KHuorqYN5w0tRrYymhhSiuDUR_Sjjt-KErUkrpY41RKnEo36Ja54iR2t--d-BPsXWiMu-sVKh3Lkl4eokvFQiFofC3llg_9_wA--rJHp</recordid><startdate>197312</startdate><enddate>197312</enddate><creator>Turlapaty, P.</creator><creator>Shibata, S.</creator><creator>Norton, T.R.</creator><creator>Kuchii, M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197312</creationdate><title>Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse</title><author>Turlapaty, P. ; Shibata, S. ; Norton, T.R. ; Kuchii, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-59d70c486adebc474d7fb9548e263c86389bddee5bf274f2a0d7e15b01d62c263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Aggression - drug effects</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain Chemistry - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cnidaria</topic><topic>Dopamine - analysis</topic><topic>Dopamine content</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Norepinephrine - analysis</topic><topic>Norepinephrine - antagonists & inhibitors</topic><topic>Norepinephrine content</topic><topic>Norepinephrine uptake</topic><topic>Normetanephrine - analysis</topic><topic>Normetanephrine - metabolism</topic><topic>Normetanephrine content</topic><topic>Peptides - pharmacology</topic><topic>Sea anemone</topic><topic>Serotonin - analysis</topic><topic>Serotonin Antagonists</topic><topic>Time Factors</topic><topic>Tissue Extracts - pharmacology</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turlapaty, P.</creatorcontrib><creatorcontrib>Shibata, S.</creatorcontrib><creatorcontrib>Norton, T.R.</creatorcontrib><creatorcontrib>Kuchii, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turlapaty, P.</au><au>Shibata, S.</au><au>Norton, T.R.</au><au>Kuchii, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1973-12</date><risdate>1973</risdate><volume>24</volume><issue>3</issue><spage>359</spage><epage>365</epage><pages>359-365</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>An active substance, polypeptide in chemical nature, causing central stimulant activity in mice has been isolated from a sea anemone. Signs of central nervous stimulatory activity produced by this substance included fighting episodes, increased motor activity and clonic convulsions. The active substance produced significant decreases in brain norepinephrine concentration both at the ED
50 (6.4 mg/kg) and the maximum effective dose (9.3 mg/kg) during the stimulation period. Brain dopamine concentration was significantly decreased by the active substance at the ED
50 dose whereas brain serotonin concentration was not affected. The ED
50 dose of the active substance significantly inhibited the re-uptake of norepinephrine during the stimulation period and elevated hormetanephrine levels. These results suggest that the active substance causes central stimulation by releasing active norepinephrine from functional pools and inhibiting its re-uptake, thus making more norepinephrine available at a adrenoceptors. It is probable that brain dopamine plays a minor role in this stimulant action of the active substance.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4148845</pmid><doi>10.1016/0014-2999(73)90163-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1973-12, Vol.24 (3), p.359-365 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82135531 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aggression - drug effects Animals Behavior, Animal - drug effects Brain Chemistry - drug effects Cerebral Cortex - metabolism Cnidaria Dopamine - analysis Dopamine content Humans Male Mice Motor Activity - drug effects Norepinephrine - analysis Norepinephrine - antagonists & inhibitors Norepinephrine content Norepinephrine uptake Normetanephrine - analysis Normetanephrine - metabolism Normetanephrine content Peptides - pharmacology Sea anemone Serotonin - analysis Serotonin Antagonists Time Factors Tissue Extracts - pharmacology Tritium |
| title | Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T14%3A18%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20central%20stimulant%20substance%20isolated%20from%20the%20sea%20anemone%20Stoichactis%20kenti%20on%20brain%20monoamines%20of%20the%20mouse&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Turlapaty,%20P.&rft.date=1973-12&rft.volume=24&rft.issue=3&rft.spage=359&rft.epage=365&rft.pages=359-365&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/10.1016/0014-2999(73)90163-5&rft_dat=%3Cproquest_cross%3E82135531%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82135531&rft_id=info:pmid/4148845&rft_els_id=0014299973901635&rfr_iscdi=true |