Left Circumflex Coronary Artery Hemodynamics in Conscious Dogs with Congenital Subaortic Stenosis
Coronary arterial hemodynamics were studied in three conscious dogs with congenital fibrous ring-type subaortic stenosis. Flow characteristics were recorded with electromagnetic flow transducers chronically implanted on the circumflex branch of the left coronary artery. Circumflex resting flow (ml/m...
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| Veröffentlicht in: | Circulation research 1973-07, Vol.33 (1), p.34-38 |
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| container_title | Circulation research |
| container_volume | 33 |
| creator | PYLE, R LEE LOWENSOHN, HOWARD S KHOURI, EDWARD M GREGG, DONALD E PATTERSON, DONALD F |
| description | Coronary arterial hemodynamics were studied in three conscious dogs with congenital fibrous ring-type subaortic stenosis. Flow characteristics were recorded with electromagnetic flow transducers chronically implanted on the circumflex branch of the left coronary artery. Circumflex resting flow (ml/min 100 g myocardium) was below that previously found in normal dogs studied by the same methods. Phasic coronary flow patterns at rest were abnormal, being characterized by reversed flow throughout most of ventricular systole. The mean reactive hyperemic response after 10 seconds of mechanical occlusion was comparable to that in normal dogs despite the essential absence of systolic forward flow. In one dog, moderate treadmill exercise substantially increased total circumflex flow despite a large increase in reversed circumflex flow. |
| doi_str_mv | 10.1161/01.RES.33.1.34 |
| format | Article |
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Flow characteristics were recorded with electromagnetic flow transducers chronically implanted on the circumflex branch of the left coronary artery. Circumflex resting flow (ml/min 100 g myocardium) was below that previously found in normal dogs studied by the same methods. Phasic coronary flow patterns at rest were abnormal, being characterized by reversed flow throughout most of ventricular systole. The mean reactive hyperemic response after 10 seconds of mechanical occlusion was comparable to that in normal dogs despite the essential absence of systolic forward flow. In one dog, moderate treadmill exercise substantially increased total circumflex flow despite a large increase in reversed circumflex flow.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.33.1.34</identifier><identifier>PMID: 4271850</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Aortic Valve Stenosis - congenital ; Aortic Valve Stenosis - pathology ; Aortic Valve Stenosis - physiopathology ; Blood Flow Velocity ; Blood Pressure ; Cardiac Output ; Cardiomegaly - etiology ; Cardiomegaly - physiopathology ; Coronary Circulation ; Coronary Vessels - pathology ; Disease Models, Animal ; Dogs ; Heart Rate ; Hyperemia - etiology ; Male ; Myocardium - pathology ; Organ Size ; Physical Exertion ; Pulmonary Circulation ; Space life sciences ; Time Factors ; Transducers</subject><ispartof>Circulation research, 1973-07, Vol.33 (1), p.34-38</ispartof><rights>1973 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4104-9ff9e145cae250971c9c75cdd010d239430224af902d8990a10e3fb60daade893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4271850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PYLE, R LEE</creatorcontrib><creatorcontrib>LOWENSOHN, HOWARD S</creatorcontrib><creatorcontrib>KHOURI, EDWARD M</creatorcontrib><creatorcontrib>GREGG, DONALD E</creatorcontrib><creatorcontrib>PATTERSON, DONALD F</creatorcontrib><title>Left Circumflex Coronary Artery Hemodynamics in Conscious Dogs with Congenital Subaortic Stenosis</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Coronary arterial hemodynamics were studied in three conscious dogs with congenital fibrous ring-type subaortic stenosis. Flow characteristics were recorded with electromagnetic flow transducers chronically implanted on the circumflex branch of the left coronary artery. Circumflex resting flow (ml/min 100 g myocardium) was below that previously found in normal dogs studied by the same methods. Phasic coronary flow patterns at rest were abnormal, being characterized by reversed flow throughout most of ventricular systole. The mean reactive hyperemic response after 10 seconds of mechanical occlusion was comparable to that in normal dogs despite the essential absence of systolic forward flow. In one dog, moderate treadmill exercise substantially increased total circumflex flow despite a large increase in reversed circumflex flow.</description><subject>Animals</subject><subject>Aortic Valve Stenosis - congenital</subject><subject>Aortic Valve Stenosis - pathology</subject><subject>Aortic Valve Stenosis - physiopathology</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>Cardiac Output</subject><subject>Cardiomegaly - etiology</subject><subject>Cardiomegaly - physiopathology</subject><subject>Coronary Circulation</subject><subject>Coronary Vessels - pathology</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Heart Rate</subject><subject>Hyperemia - etiology</subject><subject>Male</subject><subject>Myocardium - pathology</subject><subject>Organ Size</subject><subject>Physical Exertion</subject><subject>Pulmonary Circulation</subject><subject>Space life sciences</subject><subject>Time Factors</subject><subject>Transducers</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UcFu2zAMFYYNXdbu2tsAn3azR4pybR2LrFsHBBiwrGdBkelGnW11ko20fz8FCXYi-N7jA_koxDVChXiDXwCrX3fbiqjCitQbscJaqlLVDb4VKwDQZUME78WHlJ4AUJHUF-JCyQbbGlbCbrifi7WPbhn7gV-KdYhhsvG1uI0z53LPY-heJzt6lwo_ZX5KzoclFV_DYyoOft4fsUee_GyHYrvsbIizd8V25ikkn67Eu94OiT-e66V4-Hb3e31fbn5-_7G-3ZROIahS971mVLWzLGvQDTrtmtp1HSB0krQikFLZXoPsWq3BIjD1uxvorO241XQpPp98n2P4u3CazeiT42GwE-d1TSuRoG4xC6uT0MWQUuTePEc_5pMNgjlmagBNztQQGTSk8sCns_OyG7n7Lz-HmHl14g9hyJmlP8Ny4Gj2bId5b_IPgABlibohaHJXHiFF_wCcLYIV</recordid><startdate>197307</startdate><enddate>197307</enddate><creator>PYLE, R LEE</creator><creator>LOWENSOHN, HOWARD S</creator><creator>KHOURI, EDWARD M</creator><creator>GREGG, DONALD E</creator><creator>PATTERSON, DONALD F</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197307</creationdate><title>Left Circumflex Coronary Artery Hemodynamics in Conscious Dogs with Congenital Subaortic Stenosis</title><author>PYLE, R LEE ; LOWENSOHN, HOWARD S ; KHOURI, EDWARD M ; GREGG, DONALD E ; PATTERSON, DONALD F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4104-9ff9e145cae250971c9c75cdd010d239430224af902d8990a10e3fb60daade893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Aortic Valve Stenosis - congenital</topic><topic>Aortic Valve Stenosis - pathology</topic><topic>Aortic Valve Stenosis - physiopathology</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>Cardiac Output</topic><topic>Cardiomegaly - etiology</topic><topic>Cardiomegaly - physiopathology</topic><topic>Coronary Circulation</topic><topic>Coronary Vessels - pathology</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Heart Rate</topic><topic>Hyperemia - etiology</topic><topic>Male</topic><topic>Myocardium - pathology</topic><topic>Organ Size</topic><topic>Physical Exertion</topic><topic>Pulmonary Circulation</topic><topic>Space life sciences</topic><topic>Time Factors</topic><topic>Transducers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PYLE, R LEE</creatorcontrib><creatorcontrib>LOWENSOHN, HOWARD S</creatorcontrib><creatorcontrib>KHOURI, EDWARD M</creatorcontrib><creatorcontrib>GREGG, DONALD E</creatorcontrib><creatorcontrib>PATTERSON, DONALD F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PYLE, R LEE</au><au>LOWENSOHN, HOWARD S</au><au>KHOURI, EDWARD M</au><au>GREGG, DONALD E</au><au>PATTERSON, DONALD F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left Circumflex Coronary Artery Hemodynamics in Conscious Dogs with Congenital Subaortic Stenosis</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1973-07</date><risdate>1973</risdate><volume>33</volume><issue>1</issue><spage>34</spage><epage>38</epage><pages>34-38</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>Coronary arterial hemodynamics were studied in three conscious dogs with congenital fibrous ring-type subaortic stenosis. Flow characteristics were recorded with electromagnetic flow transducers chronically implanted on the circumflex branch of the left coronary artery. Circumflex resting flow (ml/min 100 g myocardium) was below that previously found in normal dogs studied by the same methods. Phasic coronary flow patterns at rest were abnormal, being characterized by reversed flow throughout most of ventricular systole. The mean reactive hyperemic response after 10 seconds of mechanical occlusion was comparable to that in normal dogs despite the essential absence of systolic forward flow. In one dog, moderate treadmill exercise substantially increased total circumflex flow despite a large increase in reversed circumflex flow.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>4271850</pmid><doi>10.1161/01.RES.33.1.34</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation research, 1973-07, Vol.33 (1), p.34-38 |
| issn | 0009-7330 1524-4571 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Aortic Valve Stenosis - congenital Aortic Valve Stenosis - pathology Aortic Valve Stenosis - physiopathology Blood Flow Velocity Blood Pressure Cardiac Output Cardiomegaly - etiology Cardiomegaly - physiopathology Coronary Circulation Coronary Vessels - pathology Disease Models, Animal Dogs Heart Rate Hyperemia - etiology Male Myocardium - pathology Organ Size Physical Exertion Pulmonary Circulation Space life sciences Time Factors Transducers |
| title | Left Circumflex Coronary Artery Hemodynamics in Conscious Dogs with Congenital Subaortic Stenosis |
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