Regional lung function in infants
Measurement of regional ventilation and blood flow in infants with the use of an intravenous bolus of Xenon reliably estimates the ventilation-perfusion abnormalities responsible for hypoxemia and eventually hypercapnea.A composite ventilation-perfusion index ( ci/ ) of >0.85 was found in well in...
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| Veröffentlicht in: | Critical care medicine 1973-11, Vol.1 (6), p.302-307 |
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| container_title | Critical care medicine |
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| creator | SHANNON, DANIEL C TODRES, I DAVID MOYLAN, FERGUS M.B |
| description | Measurement of regional ventilation and blood flow in infants with the use of an intravenous bolus of Xenon reliably estimates the ventilation-perfusion abnormalities responsible for hypoxemia and eventually hypercapnea.A composite ventilation-perfusion index ( ci/ ) of >0.85 was found in well infants with Pao2 >90 torr, and < 0.55 in sick infants with Pao2 < 50 torr. Indices of < 0.6 were associated with CO2 retention; indices of < 0.55 were found in patients requiring mechanical ventilation.Redistribution of blood flow away from a poorly ventilated region during air breathing but not during oxygen breathing suggests that alveolar hypoxia is an effective stimulus to increase regional vascular resistance. It is predictable that the lack of redistribution during oxygen breathing contributes to CO2 retention.The findings of this study substantiate the use of Xenon bolus technique for a better understanding of the regional contribution to the pathophysiology in the infantʼs lung. |
| doi_str_mv | 10.1097/00003246-197311000-00002 |
| format | Article |
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Indices of < 0.6 were associated with CO2 retention; indices of < 0.55 were found in patients requiring mechanical ventilation.Redistribution of blood flow away from a poorly ventilated region during air breathing but not during oxygen breathing suggests that alveolar hypoxia is an effective stimulus to increase regional vascular resistance. It is predictable that the lack of redistribution during oxygen breathing contributes to CO2 retention.The findings of this study substantiate the use of Xenon bolus technique for a better understanding of the regional contribution to the pathophysiology in the infantʼs lung.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-197311000-00002</identifier><identifier>PMID: 4774691</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Humans ; Hydrogen-Ion Concentration ; Infant ; Lung - physiopathology ; Oxygen - blood ; Respiratory Tract Diseases - blood ; Respiratory Tract Diseases - physiopathology ; Ventilation-Perfusion Ratio ; Xenon</subject><ispartof>Critical care medicine, 1973-11, Vol.1 (6), p.302-307</ispartof><rights>Williams & Wilkins 1973. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4774691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHANNON, DANIEL C</creatorcontrib><creatorcontrib>TODRES, I DAVID</creatorcontrib><creatorcontrib>MOYLAN, FERGUS M.B</creatorcontrib><title>Regional lung function in infants</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>Measurement of regional ventilation and blood flow in infants with the use of an intravenous bolus of Xenon reliably estimates the ventilation-perfusion abnormalities responsible for hypoxemia and eventually hypercapnea.A composite ventilation-perfusion index ( ci/ ) of >0.85 was found in well infants with Pao2 >90 torr, and < 0.55 in sick infants with Pao2 < 50 torr. Indices of < 0.6 were associated with CO2 retention; indices of < 0.55 were found in patients requiring mechanical ventilation.Redistribution of blood flow away from a poorly ventilated region during air breathing but not during oxygen breathing suggests that alveolar hypoxia is an effective stimulus to increase regional vascular resistance. It is predictable that the lack of redistribution during oxygen breathing contributes to CO2 retention.The findings of this study substantiate the use of Xenon bolus technique for a better understanding of the regional contribution to the pathophysiology in the infantʼs lung.</description><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infant</subject><subject>Lung - physiopathology</subject><subject>Oxygen - blood</subject><subject>Respiratory Tract Diseases - blood</subject><subject>Respiratory Tract Diseases - physiopathology</subject><subject>Ventilation-Perfusion Ratio</subject><subject>Xenon</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFtLwzAUx4Moc04_glBffKvmnuZRhjcYCKLPIUmTrZq1M2kZfntTN_fm4cDhf-78ACgQvEFQiluYjWDKSyQFQSirckzhIzBFjGSBJTkGUwglLAmV5BScpfQBIaJMkAmYUCEol2gKrl7dsulaHYowtMvCD63tsy6a0b1u-3QOTrwOyV3s4wy8P9y_zZ_Kxcvj8_xuUVqMGC6NsMIwrA3lnFtmNSGeemaNJKIWNafeGy-Zryvu8m3udF0xYwlxuKIuvzsD17u9m9h9DS71at0k60LQreuGpCqMsIAU58Zq12hjl1J0Xm1is9bxWyGoRjrqj4460PlNjaOX-xuDWbv6MLjHket0V992oXcxfYZh66JaOR36lfoPOvkB521t8g</recordid><startdate>197311</startdate><enddate>197311</enddate><creator>SHANNON, DANIEL C</creator><creator>TODRES, I DAVID</creator><creator>MOYLAN, FERGUS M.B</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197311</creationdate><title>Regional lung function in infants</title><author>SHANNON, DANIEL C ; TODRES, I DAVID ; MOYLAN, FERGUS M.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2152-b7c7b52ab4666c5ca33f4f5cb937d7d64ffbf95fd86e7466ead85bc33e284e293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infant</topic><topic>Lung - physiopathology</topic><topic>Oxygen - blood</topic><topic>Respiratory Tract Diseases - blood</topic><topic>Respiratory Tract Diseases - physiopathology</topic><topic>Ventilation-Perfusion Ratio</topic><topic>Xenon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHANNON, DANIEL C</creatorcontrib><creatorcontrib>TODRES, I DAVID</creatorcontrib><creatorcontrib>MOYLAN, FERGUS M.B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHANNON, DANIEL C</au><au>TODRES, I DAVID</au><au>MOYLAN, FERGUS M.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional lung function in infants</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1973-11</date><risdate>1973</risdate><volume>1</volume><issue>6</issue><spage>302</spage><epage>307</epage><pages>302-307</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><abstract>Measurement of regional ventilation and blood flow in infants with the use of an intravenous bolus of Xenon reliably estimates the ventilation-perfusion abnormalities responsible for hypoxemia and eventually hypercapnea.A composite ventilation-perfusion index ( ci/ ) of >0.85 was found in well infants with Pao2 >90 torr, and < 0.55 in sick infants with Pao2 < 50 torr. Indices of < 0.6 were associated with CO2 retention; indices of < 0.55 were found in patients requiring mechanical ventilation.Redistribution of blood flow away from a poorly ventilated region during air breathing but not during oxygen breathing suggests that alveolar hypoxia is an effective stimulus to increase regional vascular resistance. It is predictable that the lack of redistribution during oxygen breathing contributes to CO2 retention.The findings of this study substantiate the use of Xenon bolus technique for a better understanding of the regional contribution to the pathophysiology in the infantʼs lung.</abstract><cop>United States</cop><pub>Williams & Wilkins</pub><pmid>4774691</pmid><doi>10.1097/00003246-197311000-00002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1973-11, Vol.1 (6), p.302-307 |
| issn | 0090-3493 1530-0293 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Humans Hydrogen-Ion Concentration Infant Lung - physiopathology Oxygen - blood Respiratory Tract Diseases - blood Respiratory Tract Diseases - physiopathology Ventilation-Perfusion Ratio Xenon |
| title | Regional lung function in infants |
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