A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography
A quantitative gas-liquid Chromatographic method is described for the estimation of serum concentrations of ethosuximide, methsuximide, phensuximide, mephobarbital, phenobarbital, primaclone, ethadione, trimethadione, diphenylhydantoin and carbamazepine. After extraction from serum, the anticonvulsa...
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| Veröffentlicht in: | Clinica chimica acta 1973-11, Vol.48 (4), p.413-420 |
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| container_end_page | 420 |
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| container_title | Clinica chimica acta |
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| creator | Cremers, Harry M.H.G. Verheesen, Pierre E. |
| description | A quantitative gas-liquid Chromatographic method is described for the estimation of serum concentrations of ethosuximide, methsuximide, phensuximide, mephobarbital, phenobarbital, primaclone, ethadione, trimethadione, diphenylhydantoin and carbamazepine. After extraction from serum, the anticonvulsants are determined without further purification by means of three different gas Chromatographic procedures carried out on one column at different temperatures and carrier gas flows, either with or without derivative formation by means of flash heater methylation.
The method has the advantage that almost every group of anti-epileptic drugs can be examined under optimal conditions on the same column, although the structures of the groups are rather different.
Furthermore the method is rapid, sensitive and reliable. |
| doi_str_mv | 10.1016/0009-8981(73)90420-8 |
| format | Article |
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The method has the advantage that almost every group of anti-epileptic drugs can be examined under optimal conditions on the same column, although the structures of the groups are rather different.
Furthermore the method is rapid, sensitive and reliable.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(73)90420-8</identifier><identifier>PMID: 4761589</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anticonvulsants - blood ; Carbamazepine - blood ; Chromatography, Gas ; Epilepsy - blood ; Ethosuximide - blood ; Evaluation Studies as Topic ; Humans ; Mephobarbital - blood ; Methods ; Methylation ; Microchemistry ; Phenobarbital - blood ; Phenytoin - blood ; Primidone - blood ; Succinimides - blood ; Temperature ; Time Factors ; Trimethadione - blood</subject><ispartof>Clinica chimica acta, 1973-11, Vol.48 (4), p.413-420</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-b1ecbfb70c53f0b85f5cd508ce6c548ae068195274ea57cb90f90782edfaa27b3</citedby><cites>FETCH-LOGICAL-c272t-b1ecbfb70c53f0b85f5cd508ce6c548ae068195274ea57cb90f90782edfaa27b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(73)90420-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4761589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cremers, Harry M.H.G.</creatorcontrib><creatorcontrib>Verheesen, Pierre E.</creatorcontrib><title>A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>A quantitative gas-liquid Chromatographic method is described for the estimation of serum concentrations of ethosuximide, methsuximide, phensuximide, mephobarbital, phenobarbital, primaclone, ethadione, trimethadione, diphenylhydantoin and carbamazepine. After extraction from serum, the anticonvulsants are determined without further purification by means of three different gas Chromatographic procedures carried out on one column at different temperatures and carrier gas flows, either with or without derivative formation by means of flash heater methylation.
The method has the advantage that almost every group of anti-epileptic drugs can be examined under optimal conditions on the same column, although the structures of the groups are rather different.
Furthermore the method is rapid, sensitive and reliable.</description><subject>Anticonvulsants - blood</subject><subject>Carbamazepine - blood</subject><subject>Chromatography, Gas</subject><subject>Epilepsy - blood</subject><subject>Ethosuximide - blood</subject><subject>Evaluation Studies as Topic</subject><subject>Humans</subject><subject>Mephobarbital - blood</subject><subject>Methods</subject><subject>Methylation</subject><subject>Microchemistry</subject><subject>Phenobarbital - blood</subject><subject>Phenytoin - blood</subject><subject>Primidone - blood</subject><subject>Succinimides - blood</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Trimethadione - blood</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4_j4BwpZiS6qSfpIuhGGwRcIbnQdkvRmJtI2NWmF-fdmnMGlq8vlnnMu50PogpJbSmh1RwipM1ELes3zm5oUjGTiAM2p4HmWFzU7RPM_yTE6ifEzrQWp6AzNCl7RUtRzBAsc1OAa3MG49g22PuBxDRji6Do1Ot9jb7HqR5fB4FoYRmdwE6ZVxK7HuvXJEyFMHdYbvFIxa93XlOLMOvjk96uUvt6coSOr2gjn-3mKPh4f3pfP2evb08ty8ZoZxtmYaQpGW82JKXNLtChtaZqSCAOVKQuhgFSC1iXjBaiSG10TWxMuGDRWKcZ1foqudrlD8F9T6iA7Fw20rerBT1EKRllysyQsdkITfIwBrBxC6hs2khK5pSu36OQWneS5_KUrRbJd7vMn3UHzZ9rjTPf73R1SyW8HQUbjoDfQuABmlI13_z_4AceDirQ</recordid><startdate>19731115</startdate><enddate>19731115</enddate><creator>Cremers, Harry M.H.G.</creator><creator>Verheesen, Pierre E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19731115</creationdate><title>A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography</title><author>Cremers, Harry M.H.G. ; Verheesen, Pierre E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-b1ecbfb70c53f0b85f5cd508ce6c548ae068195274ea57cb90f90782edfaa27b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Anticonvulsants - blood</topic><topic>Carbamazepine - blood</topic><topic>Chromatography, Gas</topic><topic>Epilepsy - blood</topic><topic>Ethosuximide - blood</topic><topic>Evaluation Studies as Topic</topic><topic>Humans</topic><topic>Mephobarbital - blood</topic><topic>Methods</topic><topic>Methylation</topic><topic>Microchemistry</topic><topic>Phenobarbital - blood</topic><topic>Phenytoin - blood</topic><topic>Primidone - blood</topic><topic>Succinimides - blood</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Trimethadione - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cremers, Harry M.H.G.</creatorcontrib><creatorcontrib>Verheesen, Pierre E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cremers, Harry M.H.G.</au><au>Verheesen, Pierre E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1973-11-15</date><risdate>1973</risdate><volume>48</volume><issue>4</issue><spage>413</spage><epage>420</epage><pages>413-420</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>A quantitative gas-liquid Chromatographic method is described for the estimation of serum concentrations of ethosuximide, methsuximide, phensuximide, mephobarbital, phenobarbital, primaclone, ethadione, trimethadione, diphenylhydantoin and carbamazepine. After extraction from serum, the anticonvulsants are determined without further purification by means of three different gas Chromatographic procedures carried out on one column at different temperatures and carrier gas flows, either with or without derivative formation by means of flash heater methylation.
The method has the advantage that almost every group of anti-epileptic drugs can be examined under optimal conditions on the same column, although the structures of the groups are rather different.
Furthermore the method is rapid, sensitive and reliable.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4761589</pmid><doi>10.1016/0009-8981(73)90420-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1973-11, Vol.48 (4), p.413-420 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anticonvulsants - blood Carbamazepine - blood Chromatography, Gas Epilepsy - blood Ethosuximide - blood Evaluation Studies as Topic Humans Mephobarbital - blood Methods Methylation Microchemistry Phenobarbital - blood Phenytoin - blood Primidone - blood Succinimides - blood Temperature Time Factors Trimethadione - blood |
| title | A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography |
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