Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells

Abstract Introduation Resveratrol, a phytoestrogen present at a high concentration in red wine, has been reported to possess many health benefit effects that are protective against age-related diseases. Protein S (PS), an important anticoagulant factor in the protein C (PC) anticoagulant pathway, is...

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Veröffentlicht in:	Thrombosis research 2011-01, Vol.127 (1), p.e1-e7
Hauptverfasser:	Hiroto, Yoshie, Tadokoro, Kana, Tsuda, Tomohide, Nakazono, Eri, Ohnaka, Keizo, Takayanagi, Ryoichi, Hamasaki, Naotaka, Tsuda, Hiroko
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Proteins - genetics Blood Proteins - metabolism Blotting, Western Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Dose-Response Relationship, Drug Down-Regulation Enzyme-Linked Immunosorbent Assay Estrogen Receptor alpha - metabolism Gene Expression Regulation, Neoplastic - drug effects Genistein - pharmacology Hematology, Oncology and Palliative Medicine Hep G2 Cells HepG2 cells Histocompatibility Antigens - metabolism Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Molecular Structure Phytoestrogen Phytoestrogens - chemistry Phytoestrogens - pharmacology Promoter Regions, Genetic - drug effects Protein C - metabolism Protein C anticoagulant pathway Protein S Protein S - genetics Protein S - metabolism Resveratrol Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Stilbenes - chemistry Stilbenes - pharmacology Structure-Activity Relationship Time Factors Transcription, Genetic - drug effects Transfection Wine
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