A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro

Immunotherapy is a promising strategy for the treatment of human epidermal growth factor receptor 2 (HER2)-positive tumors. Previously, we constructed an immuno-carboxy terminal fragment of Bid (immuno-tBid) and reported its specific and effective destruction of HER2-positive tumor cells. In this st...

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Veröffentlicht in:	Oncology reports 2011-02, Vol.25 (2), p.325-331
Hauptverfasser:	SHAN, Le-Qun, SAI MA, QIU, Xiu-Chun, TAO WANG, YU, Shi-Bin, MA, Bao-An, YONG ZHOU, FAN, Qing-Yu, YANG, An-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	BH3 Interacting Domain Death Agonist Protein - chemistry BH3 Interacting Domain Death Agonist Protein - pharmacology Binding Sites Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Proliferation - drug effects Diseases of the osteoarticular system Down-Regulation - drug effects Drug Evaluation, Preclinical Furin - metabolism HeLa Cells Humans Immunoconjugates - chemistry Immunoconjugates - pharmacology Medical sciences Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Peptide Fragments - chemistry Peptide Fragments - pharmacology Protein Structure, Tertiary - physiology Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - pharmacology Transfection Tumor Cells, Cultured Tumors Tumors of striated muscle and skeleton
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