Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes

In the present study, resveratrol, a polyphenolic SIRT1 activator was evaluated for its SIRT1 activation in an in vitro fluorescent based assay (EC50: 7 μM). The efficacy of resveratrol was also evaluated in ob/ob mice for its antidiabetic and associated metabolic effects. Mice aged 5–8 weeks were i...

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Veröffentlicht in:	Phytotherapy research 2011-01, Vol.25 (1), p.67-73
Hauptverfasser:	Sharma, Sameer, Misra, Chandra Sekhar, Arumugam, Surendar, Roy, Subhasis, Shah, Vanya, Davis, Joseph Alex, Shirumalla, Raj Kumar, Ray, Abhijit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - blood Animals Biological and medical sciences Body Weight - drug effects Chemotherapy, Adjuvant Cholesterol - blood Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Enzyme Activation - drug effects Fatty Acids, Nonesterified - blood General pharmacology Glucose - pharmacology Glucose Tolerance Test Hypoglycemic Agents - pharmacology Insulin - blood Medical sciences Mice ob/ob mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments resveratrol SIRT1 Sirtuin 1 - metabolism Stilbenes - pharmacology Triglycerides - blood type-2 diabetes
Online-Zugang:	Volltext
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