Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment
Please cite this paper as: Clough, L’Esperance, Turzyniecka, Walter, Chipperfield, Gamble, Krentz and Byrne (2011). Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment. Microcirculation18 (1), 7...
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| Veröffentlicht in: | Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2011-01, Vol.18 (1), p.74-84 |
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| creator | CLOUGH, GERALDINE F. L'ESPERANCE, VELINE TURZYNIECKA, MAGDALENA WALTER, LARA CHIPPERFIELD, ANDREW J. GAMBLE, JOHN KRENTZ, ANDREW J. BYRNE, CHRISTOPHER D. |
| description | Please cite this paper as: Clough, L’Esperance, Turzyniecka, Walter, Chipperfield, Gamble, Krentz and Byrne (2011). Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment. Microcirculation18 (1), 74–84.
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin‐induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = −0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p |
| doi_str_mv | 10.1111/j.1549-8719.2010.00070.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_821200586</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>821200586</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3560-bc070ae4c4e1f757de5712238f304fbe5a221df1cf8fee5898620d0bd8cb00433</originalsourceid><addsrcrecordid>eNo9kd9u2yAYxa1p09p1e4WJu105-8B_wNJuIqdpI7Wr1HbaJcL4c0tm48zgNn6Yvetw04YLQJzzOwJOFBEKCxrG9-2CZmkRC06LBYNwCgAcFvt30elReB_2wJO4yIU4iT45tw0mIVjxMTphlOZ5wcRp9G89Wu1Nb1VLVqZVvh9IqXZKGz8R48jG1rjDMFnfTmTpXK-N8liTZ-Mfg-rG1lhyh9YZb55mSNmaLB-QhOMyUEMIvqnQvUkh0_aebLrd0D-FnGoil-bhkax6h-TOKx-4-wGV7wL8OfrQqNbhl9f1LPq1Pr8vL-Orm4tNubyKdZLlEFc6vF5hqlOkDc94jRmnjCWiSSBtKswUY7RuqG5Eg5iJQuQMaqhqoSuANEnOom-H3HCpvyM6LzvjNLatstiPTgpGGUAm8uD8-uocqw5ruRtMp4ZJvv1oMPw4GJ5Ni9NRpyDn5uRWzgXJuSA5NydfmpN7eb0pSw4Bjw-4cR73R1wNf2TOE57J3z8vJF2tb1OgXN4m_wEBc50_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>821200586</pqid></control><display><type>article</type><title>Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>CLOUGH, GERALDINE F. ; L'ESPERANCE, VELINE ; TURZYNIECKA, MAGDALENA ; WALTER, LARA ; CHIPPERFIELD, ANDREW J. ; GAMBLE, JOHN ; KRENTZ, ANDREW J. ; BYRNE, CHRISTOPHER D.</creator><creatorcontrib>CLOUGH, GERALDINE F. ; L'ESPERANCE, VELINE ; TURZYNIECKA, MAGDALENA ; WALTER, LARA ; CHIPPERFIELD, ANDREW J. ; GAMBLE, JOHN ; KRENTZ, ANDREW J. ; BYRNE, CHRISTOPHER D.</creatorcontrib><description>Please cite this paper as: Clough, L’Esperance, Turzyniecka, Walter, Chipperfield, Gamble, Krentz and Byrne (2011). Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment. Microcirculation18 (1), 74–84.
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin‐induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = −0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
Conclusions: Insulin sensitivity and age are independently associated with an insulin‐induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/j.1549-8719.2010.00070.x</identifier><identifier>PMID: 21166928</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Adult ; Aged ; Anticholesteremic Agents - administration & dosage ; Atorvastatin Calcium ; Blood Flow Velocity - drug effects ; central obesity ; endothelium ; Female ; Heptanoic Acids - administration & dosage ; Humans ; Hyperemia - drug therapy ; Hyperemia - physiopathology ; Hyperinsulinism - drug therapy ; Hyperinsulinism - physiopathology ; Insulin Resistance ; insulin sensitivity ; laser Doppler fluximetry ; Male ; Microcirculation - drug effects ; microvasculature ; Middle Aged ; Obesity, Abdominal - drug therapy ; Obesity, Abdominal - physiopathology ; Pyrroles - administration & dosage ; Risk Factors ; skin ; statins ; Vasodilation - drug effects</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2011-01, Vol.18 (1), p.74-84</ispartof><rights>2010 John Wiley & Sons Ltd</rights><rights>2010 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3560-bc070ae4c4e1f757de5712238f304fbe5a221df1cf8fee5898620d0bd8cb00433</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1549-8719.2010.00070.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1549-8719.2010.00070.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21166928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CLOUGH, GERALDINE F.</creatorcontrib><creatorcontrib>L'ESPERANCE, VELINE</creatorcontrib><creatorcontrib>TURZYNIECKA, MAGDALENA</creatorcontrib><creatorcontrib>WALTER, LARA</creatorcontrib><creatorcontrib>CHIPPERFIELD, ANDREW J.</creatorcontrib><creatorcontrib>GAMBLE, JOHN</creatorcontrib><creatorcontrib>KRENTZ, ANDREW J.</creatorcontrib><creatorcontrib>BYRNE, CHRISTOPHER D.</creatorcontrib><title>Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Please cite this paper as: Clough, L’Esperance, Turzyniecka, Walter, Chipperfield, Gamble, Krentz and Byrne (2011). Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment. Microcirculation18 (1), 74–84.
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin‐induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = −0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
Conclusions: Insulin sensitivity and age are independently associated with an insulin‐induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Anticholesteremic Agents - administration & dosage</subject><subject>Atorvastatin Calcium</subject><subject>Blood Flow Velocity - drug effects</subject><subject>central obesity</subject><subject>endothelium</subject><subject>Female</subject><subject>Heptanoic Acids - administration & dosage</subject><subject>Humans</subject><subject>Hyperemia - drug therapy</subject><subject>Hyperemia - physiopathology</subject><subject>Hyperinsulinism - drug therapy</subject><subject>Hyperinsulinism - physiopathology</subject><subject>Insulin Resistance</subject><subject>insulin sensitivity</subject><subject>laser Doppler fluximetry</subject><subject>Male</subject><subject>Microcirculation - drug effects</subject><subject>microvasculature</subject><subject>Middle Aged</subject><subject>Obesity, Abdominal - drug therapy</subject><subject>Obesity, Abdominal - physiopathology</subject><subject>Pyrroles - administration & dosage</subject><subject>Risk Factors</subject><subject>skin</subject><subject>statins</subject><subject>Vasodilation - drug effects</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kd9u2yAYxa1p09p1e4WJu105-8B_wNJuIqdpI7Wr1HbaJcL4c0tm48zgNn6Yvetw04YLQJzzOwJOFBEKCxrG9-2CZmkRC06LBYNwCgAcFvt30elReB_2wJO4yIU4iT45tw0mIVjxMTphlOZ5wcRp9G89Wu1Nb1VLVqZVvh9IqXZKGz8R48jG1rjDMFnfTmTpXK-N8liTZ-Mfg-rG1lhyh9YZb55mSNmaLB-QhOMyUEMIvqnQvUkh0_aebLrd0D-FnGoil-bhkax6h-TOKx-4-wGV7wL8OfrQqNbhl9f1LPq1Pr8vL-Orm4tNubyKdZLlEFc6vF5hqlOkDc94jRmnjCWiSSBtKswUY7RuqG5Eg5iJQuQMaqhqoSuANEnOom-H3HCpvyM6LzvjNLatstiPTgpGGUAm8uD8-uocqw5ruRtMp4ZJvv1oMPw4GJ5Ni9NRpyDn5uRWzgXJuSA5NydfmpN7eb0pSw4Bjw-4cR73R1wNf2TOE57J3z8vJF2tb1OgXN4m_wEBc50_</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>CLOUGH, GERALDINE F.</creator><creator>L'ESPERANCE, VELINE</creator><creator>TURZYNIECKA, MAGDALENA</creator><creator>WALTER, LARA</creator><creator>CHIPPERFIELD, ANDREW J.</creator><creator>GAMBLE, JOHN</creator><creator>KRENTZ, ANDREW J.</creator><creator>BYRNE, CHRISTOPHER D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment</title><author>CLOUGH, GERALDINE F. ; L'ESPERANCE, VELINE ; TURZYNIECKA, MAGDALENA ; WALTER, LARA ; CHIPPERFIELD, ANDREW J. ; GAMBLE, JOHN ; KRENTZ, ANDREW J. ; BYRNE, CHRISTOPHER D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3560-bc070ae4c4e1f757de5712238f304fbe5a221df1cf8fee5898620d0bd8cb00433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Anticholesteremic Agents - administration & dosage</topic><topic>Atorvastatin Calcium</topic><topic>Blood Flow Velocity - drug effects</topic><topic>central obesity</topic><topic>endothelium</topic><topic>Female</topic><topic>Heptanoic Acids - administration & dosage</topic><topic>Humans</topic><topic>Hyperemia - drug therapy</topic><topic>Hyperemia - physiopathology</topic><topic>Hyperinsulinism - drug therapy</topic><topic>Hyperinsulinism - physiopathology</topic><topic>Insulin Resistance</topic><topic>insulin sensitivity</topic><topic>laser Doppler fluximetry</topic><topic>Male</topic><topic>Microcirculation - drug effects</topic><topic>microvasculature</topic><topic>Middle Aged</topic><topic>Obesity, Abdominal - drug therapy</topic><topic>Obesity, Abdominal - physiopathology</topic><topic>Pyrroles - administration & dosage</topic><topic>Risk Factors</topic><topic>skin</topic><topic>statins</topic><topic>Vasodilation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CLOUGH, GERALDINE F.</creatorcontrib><creatorcontrib>L'ESPERANCE, VELINE</creatorcontrib><creatorcontrib>TURZYNIECKA, MAGDALENA</creatorcontrib><creatorcontrib>WALTER, LARA</creatorcontrib><creatorcontrib>CHIPPERFIELD, ANDREW J.</creatorcontrib><creatorcontrib>GAMBLE, JOHN</creatorcontrib><creatorcontrib>KRENTZ, ANDREW J.</creatorcontrib><creatorcontrib>BYRNE, CHRISTOPHER D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CLOUGH, GERALDINE F.</au><au>L'ESPERANCE, VELINE</au><au>TURZYNIECKA, MAGDALENA</au><au>WALTER, LARA</au><au>CHIPPERFIELD, ANDREW J.</au><au>GAMBLE, JOHN</au><au>KRENTZ, ANDREW J.</au><au>BYRNE, CHRISTOPHER D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2011-01</date><risdate>2011</risdate><volume>18</volume><issue>1</issue><spage>74</spage><epage>84</epage><pages>74-84</pages><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Please cite this paper as: Clough, L’Esperance, Turzyniecka, Walter, Chipperfield, Gamble, Krentz and Byrne (2011). Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment. Microcirculation18 (1), 74–84.
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin‐induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = −0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
Conclusions: Insulin sensitivity and age are independently associated with an insulin‐induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21166928</pmid><doi>10.1111/j.1549-8719.2010.00070.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Acute Disease Adult Aged Anticholesteremic Agents - administration & dosage Atorvastatin Calcium Blood Flow Velocity - drug effects central obesity endothelium Female Heptanoic Acids - administration & dosage Humans Hyperemia - drug therapy Hyperemia - physiopathology Hyperinsulinism - drug therapy Hyperinsulinism - physiopathology Insulin Resistance insulin sensitivity laser Doppler fluximetry Male Microcirculation - drug effects microvasculature Middle Aged Obesity, Abdominal - drug therapy Obesity, Abdominal - physiopathology Pyrroles - administration & dosage Risk Factors skin statins Vasodilation - drug effects |
| title | Functional Dilator Capacity is Independently Associated with Insulin Sensitivity and Age in Central Obesity and is not Improved by High Dose Statin Treatment |
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