Tandem free-radical addition/substitution chemistry and its application to the preparation of novel AT1 receptor antagonists

Benzothiophene and benzoselenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. While the sulfur-containing systems were prepared following existing methodology, the selenium-containing analogue...

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Veröffentlicht in:	Organic & biomolecular chemistry 2011-01, Vol.9 (2), p.473-479
Hauptverfasser:	Staples, Maree K, Grange, Rebecca L, Angus, James A, Ziogas, James, Tan, Nichole P H, Taylor, Michelle K, Schiesser, Carl H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - chemistry Free Radicals - chemistry Molecular Structure
Online-Zugang:	Volltext
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