Epstein-barr virus in diffuse large B-Cell lymphoma in immunocompetent patients in Japan is as low as in Western Countries
According to previous reports, the frequency of Epstein–Barr virus (EBV) positivity in diffuse large B‐cell lymphoma is higher in East Asia (approximately 9%) than in Western countries. The presence of the EBV genome was examined in diffuse large B‐cell lymphoma patients registered with the Osaka Ly...
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| creator | Wada, Naoki Ikeda, Junichiro Hori, Yumiko Fujita, Shigeki Ogawa, Hiroyasu Soma, Toshihiro Sugiyama, Haruo Fukuhara, Shirou Kanamaru, Akihisa Hino, Masayuki Kanakura, Yuzuru Morii, Eiichi Aozasa, Katsuyuki |
| description | According to previous reports, the frequency of Epstein–Barr virus (EBV) positivity in diffuse large B‐cell lymphoma is higher in East Asia (approximately 9%) than in Western countries. The presence of the EBV genome was examined in diffuse large B‐cell lymphoma patients registered with the Osaka Lymphoma Study Group (OLSG) in Osaka, Japan, situated in East Asia. The EBV‐positive rate was examined with in situ hybridization (ISH) in 484 immunocompetent diffuse large B‐cell lymphoma patients registered with OLSG. The male‐to‐female ratio was 1.29, with ages ranging from 16 to 95 (median, 68) years. ISH with EBV‐encoded small RNAs (EBER) probes revealed positive signals in the nuclei of tumor cells: the frequency of positively stained cells among all tumor cells was almost none in 458 cases, 5–10% in 5, 10–20% in 5, 20–50% in 11, and >50% in 5. When the frequency was >20% or >50%, the EBV‐positive rate in the present series (3.3% or 1.0%) was rather similar to that reported in Western cases. Careful evaluation of patient backgrounds, including age distribution, type of lymphomas, exclusion of immunocompromised patients, and establishment of definite criteria for EBV positivity (>20%, >50%, or almost all tumor cells) are essential in comparing geographical differences. J. Med. Virol. 83:317–321, 2011. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmv.21967 |
| format | Article |
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The presence of the EBV genome was examined in diffuse large B‐cell lymphoma patients registered with the Osaka Lymphoma Study Group (OLSG) in Osaka, Japan, situated in East Asia. The EBV‐positive rate was examined with in situ hybridization (ISH) in 484 immunocompetent diffuse large B‐cell lymphoma patients registered with OLSG. The male‐to‐female ratio was 1.29, with ages ranging from 16 to 95 (median, 68) years. ISH with EBV‐encoded small RNAs (EBER) probes revealed positive signals in the nuclei of tumor cells: the frequency of positively stained cells among all tumor cells was almost none in 458 cases, 5–10% in 5, 10–20% in 5, 20–50% in 11, and >50% in 5. When the frequency was >20% or >50%, the EBV‐positive rate in the present series (3.3% or 1.0%) was rather similar to that reported in Western cases. Careful evaluation of patient backgrounds, including age distribution, type of lymphomas, exclusion of immunocompromised patients, and establishment of definite criteria for EBV positivity (>20%, >50%, or almost all tumor cells) are essential in comparing geographical differences. J. Med. Virol. 83:317–321, 2011. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.21967</identifier><identifier>PMID: 21181929</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; diffuse large B-cell lymphoma ; Epstein-Barr virus ; Epstein-Barr Virus Infections - epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; geographical differences ; Herpesvirus 4, Human - isolation & purification ; Human viral diseases ; Humans ; Immunocompetence ; in situ hybridization ; Infectious diseases ; Japan - epidemiology ; Lymphoma, Large B-Cell, Diffuse - epidemiology ; Lymphoma, Large B-Cell, Diffuse - immunology ; Lymphoma, Large B-Cell, Diffuse - virology ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Tumors ; Viral diseases ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2011-02, Vol.83 (2), p.317-321</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2010 Wiley-Liss, Inc.</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5197-7881df6b6b9513a04fee89f3649ce753f69ab8e5f8621c1d1d9107a0015e13ac3</citedby><cites>FETCH-LOGICAL-c5197-7881df6b6b9513a04fee89f3649ce753f69ab8e5f8621c1d1d9107a0015e13ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.21967$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.21967$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23784289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21181929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wada, Naoki</creatorcontrib><creatorcontrib>Ikeda, Junichiro</creatorcontrib><creatorcontrib>Hori, Yumiko</creatorcontrib><creatorcontrib>Fujita, Shigeki</creatorcontrib><creatorcontrib>Ogawa, Hiroyasu</creatorcontrib><creatorcontrib>Soma, Toshihiro</creatorcontrib><creatorcontrib>Sugiyama, Haruo</creatorcontrib><creatorcontrib>Fukuhara, Shirou</creatorcontrib><creatorcontrib>Kanamaru, Akihisa</creatorcontrib><creatorcontrib>Hino, Masayuki</creatorcontrib><creatorcontrib>Kanakura, Yuzuru</creatorcontrib><creatorcontrib>Morii, Eiichi</creatorcontrib><creatorcontrib>Aozasa, Katsuyuki</creatorcontrib><title>Epstein-barr virus in diffuse large B-Cell lymphoma in immunocompetent patients in Japan is as low as in Western Countries</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>According to previous reports, the frequency of Epstein–Barr virus (EBV) positivity in diffuse large B‐cell lymphoma is higher in East Asia (approximately 9%) than in Western countries. The presence of the EBV genome was examined in diffuse large B‐cell lymphoma patients registered with the Osaka Lymphoma Study Group (OLSG) in Osaka, Japan, situated in East Asia. The EBV‐positive rate was examined with in situ hybridization (ISH) in 484 immunocompetent diffuse large B‐cell lymphoma patients registered with OLSG. The male‐to‐female ratio was 1.29, with ages ranging from 16 to 95 (median, 68) years. ISH with EBV‐encoded small RNAs (EBER) probes revealed positive signals in the nuclei of tumor cells: the frequency of positively stained cells among all tumor cells was almost none in 458 cases, 5–10% in 5, 10–20% in 5, 20–50% in 11, and >50% in 5. When the frequency was >20% or >50%, the EBV‐positive rate in the present series (3.3% or 1.0%) was rather similar to that reported in Western cases. Careful evaluation of patient backgrounds, including age distribution, type of lymphomas, exclusion of immunocompromised patients, and establishment of definite criteria for EBV positivity (>20%, >50%, or almost all tumor cells) are essential in comparing geographical differences. J. Med. Virol. 83:317–321, 2011. © 2010 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>diffuse large B-cell lymphoma</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>geographical differences</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>in situ hybridization</subject><subject>Infectious diseases</subject><subject>Japan - epidemiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - epidemiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - immunology</subject><subject>Lymphoma, Large B-Cell, Diffuse - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Tumors</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90VFv1SAUB3BiXNx1-uAXMCRmUR-6cWih8Oju5uYyN02meyS0BeXa0grt5vXTj7t7NxMTfToJ_A4H-CP0AsgeEEL3F931HgXJy0doBkTyTJISHqMZgYJnnAPbRk9jXBBChKT0CdqmAAIklTP0-2iIo3E-q3QI-NqFKWLnceOsnaLBrQ7fDD7I5qZtcbvshu99p1fAdd3k-7rvBjMaP-JBjy7Vu-ZTPegkItYRt_3NqqTVK5MGBY_n_eTH4Ex8hrasbqN5vqk76Mv7o8v5SXZ2cfxh_u4sqxnIMiuFgMbyileSQa5JYY0R0ua8kLUpWW651JUwzApOoYYGGgmk1IQAM8nX-Q56vT53CP3PKd1CdS7W6UHam36KSqTfkFJCkeSb_0pgnAAFKnmir_6ii34KPr0jqYIRwSSTSb1dqzr0MQZj1RBcp8NSAVGr6FSKTt1Fl-zLzYlT1ZnmQd5nlcDuBuhY69YG7WsX_7i8FAUVK7e_djeuNct_T1SnH7_ej87WHS5F9OuhQ4cfKu2WTF2dH6uT4vCS80-f1WF-CzSUvjo</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Wada, Naoki</creator><creator>Ikeda, Junichiro</creator><creator>Hori, Yumiko</creator><creator>Fujita, Shigeki</creator><creator>Ogawa, Hiroyasu</creator><creator>Soma, Toshihiro</creator><creator>Sugiyama, Haruo</creator><creator>Fukuhara, Shirou</creator><creator>Kanamaru, Akihisa</creator><creator>Hino, Masayuki</creator><creator>Kanakura, Yuzuru</creator><creator>Morii, Eiichi</creator><creator>Aozasa, Katsuyuki</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>201102</creationdate><title>Epstein-barr virus in diffuse large B-Cell lymphoma in immunocompetent patients in Japan is as low as in Western Countries</title><author>Wada, Naoki ; Ikeda, Junichiro ; Hori, Yumiko ; Fujita, Shigeki ; Ogawa, Hiroyasu ; Soma, Toshihiro ; Sugiyama, Haruo ; Fukuhara, Shirou ; Kanamaru, Akihisa ; Hino, Masayuki ; Kanakura, Yuzuru ; Morii, Eiichi ; Aozasa, Katsuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5197-7881df6b6b9513a04fee89f3649ce753f69ab8e5f8621c1d1d9107a0015e13ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>diffuse large B-cell lymphoma</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>geographical differences</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>in situ hybridization</topic><topic>Infectious diseases</topic><topic>Japan - epidemiology</topic><topic>Lymphoma, Large B-Cell, Diffuse - epidemiology</topic><topic>Lymphoma, Large B-Cell, Diffuse - immunology</topic><topic>Lymphoma, Large B-Cell, Diffuse - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Tumors</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wada, Naoki</creatorcontrib><creatorcontrib>Ikeda, Junichiro</creatorcontrib><creatorcontrib>Hori, Yumiko</creatorcontrib><creatorcontrib>Fujita, Shigeki</creatorcontrib><creatorcontrib>Ogawa, Hiroyasu</creatorcontrib><creatorcontrib>Soma, Toshihiro</creatorcontrib><creatorcontrib>Sugiyama, Haruo</creatorcontrib><creatorcontrib>Fukuhara, Shirou</creatorcontrib><creatorcontrib>Kanamaru, Akihisa</creatorcontrib><creatorcontrib>Hino, Masayuki</creatorcontrib><creatorcontrib>Kanakura, Yuzuru</creatorcontrib><creatorcontrib>Morii, Eiichi</creatorcontrib><creatorcontrib>Aozasa, Katsuyuki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wada, Naoki</au><au>Ikeda, Junichiro</au><au>Hori, Yumiko</au><au>Fujita, Shigeki</au><au>Ogawa, Hiroyasu</au><au>Soma, Toshihiro</au><au>Sugiyama, Haruo</au><au>Fukuhara, Shirou</au><au>Kanamaru, Akihisa</au><au>Hino, Masayuki</au><au>Kanakura, Yuzuru</au><au>Morii, Eiichi</au><au>Aozasa, Katsuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-barr virus in diffuse large B-Cell lymphoma in immunocompetent patients in Japan is as low as in Western Countries</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2011-02</date><risdate>2011</risdate><volume>83</volume><issue>2</issue><spage>317</spage><epage>321</epage><pages>317-321</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>According to previous reports, the frequency of Epstein–Barr virus (EBV) positivity in diffuse large B‐cell lymphoma is higher in East Asia (approximately 9%) than in Western countries. The presence of the EBV genome was examined in diffuse large B‐cell lymphoma patients registered with the Osaka Lymphoma Study Group (OLSG) in Osaka, Japan, situated in East Asia. The EBV‐positive rate was examined with in situ hybridization (ISH) in 484 immunocompetent diffuse large B‐cell lymphoma patients registered with OLSG. The male‐to‐female ratio was 1.29, with ages ranging from 16 to 95 (median, 68) years. ISH with EBV‐encoded small RNAs (EBER) probes revealed positive signals in the nuclei of tumor cells: the frequency of positively stained cells among all tumor cells was almost none in 458 cases, 5–10% in 5, 10–20% in 5, 20–50% in 11, and >50% in 5. When the frequency was >20% or >50%, the EBV‐positive rate in the present series (3.3% or 1.0%) was rather similar to that reported in Western cases. Careful evaluation of patient backgrounds, including age distribution, type of lymphomas, exclusion of immunocompromised patients, and establishment of definite criteria for EBV positivity (>20%, >50%, or almost all tumor cells) are essential in comparing geographical differences. J. Med. Virol. 83:317–321, 2011. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21181929</pmid><doi>10.1002/jmv.21967</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens diffuse large B-cell lymphoma Epstein-Barr virus Epstein-Barr Virus Infections - epidemiology Female Fundamental and applied biological sciences. Psychology geographical differences Herpesvirus 4, Human - isolation & purification Human viral diseases Humans Immunocompetence in situ hybridization Infectious diseases Japan - epidemiology Lymphoma, Large B-Cell, Diffuse - epidemiology Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - virology Male Medical sciences Microbiology Middle Aged Miscellaneous Tumors Viral diseases Virology Viruses |
| title | Epstein-barr virus in diffuse large B-Cell lymphoma in immunocompetent patients in Japan is as low as in Western Countries |
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