Upregulation of Dicer and MicroRNA Expression in the Dorsolateral Prefrontal Cortex Brodmann Area 46 in Schizophrenia

Background MicroRNA (miRNA) are capable of regulating multitudes of target genes and are essential factors in mediating healthy neurodevelopment. We hypothesize that abnormal miRNA levels contribute to the complex global changes in gene expression that underlie the pathophysiology of schizophrenia....

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Veröffentlicht in:	Biological psychiatry (1969) 2011-01, Vol.69 (2), p.180-187
Hauptverfasser:	Santarelli, Danielle M, Beveridge, Natalie J, Tooney, Paul A, Cairns, Murray J
Format:	Artikel
Sprache:	eng
Schlagworte:	BA46 Case-Control Studies dicer Gene Expression Profiling gene silencing Humans Matched-Pair Analysis microRNA MicroRNAs - metabolism neuropathology Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychiatry Psychotic Disorders - genetics Psychotic Disorders - metabolism Psychotic Disorders - physiopathology Reference Values Ribonucleases - metabolism schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Schizophrenia - physiopathology Up-Regulation
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