Velocity profiles and shear strain rate variability in the USP Dissolution Testing Apparatus 2 at different impeller agitation speeds

The fluid velocity profiles at different locations inside a standard USP Dissolution Testing Apparatus 2 were experimentally obtained via Laser Doppler Velocimetry (LDV) at three impeller agitations speeds, namely 50rpm, 75rpm and 100rpm. The experimental results were compared with the predictions o...

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Veröffentlicht in:	International journal of pharmaceutics 2011-01, Vol.403 (1-2), p.1-14
Hauptverfasser:	Bai, Ge, Wang, Yimin, Armenante, Piero M.
Format:	Artikel
Sprache:	eng
Schlagworte:	agitation Agitation speed Biological and medical sciences Chemistry, Pharmaceutical - instrumentation Computational Fluid Dynamics (CFD) Computer Simulation Dissolution testing General pharmacology Hydrodynamics Laser Doppler Velocimetry (LDV) Laser-Doppler Flowmetry Medical sciences Models, Chemical Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - standards Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacopoeias as Topic prediction Reynolds number Shear strain rate Shear Strength Solubility Solutions turbulent flow United States USP Dissolution Testing Apparatus 2 Velocity profiles
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