Functionalized Cyclic RGD Peptidomimetics: Conjugable ligands for αvβ3 Receptor Imaging

The αvβ3 integrin is an adhesion molecule involved in physiological and pathological angiogenesis as well as in tumor invasion and metastasis, and therefore, there is a strong interest in developing novel agents interacting with this molecule. We report the synthesis and characterization of fluoresc...

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Veröffentlicht in:	Bioconjugate chemistry 2009-08, Vol.20 (8), p.1611-1617
Hauptverfasser:	Arosio, Daniela, Manzoni, Leonardo, Araldi, Elena M. V, Caprini, Andrea, Monferini, Eugenia, Scolastico, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cells, Cultured Endothelial Cells - metabolism Fluorescent Dyes - analysis Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Humans Integrin alphaVbeta3 - analysis Integrin alphaVbeta3 - metabolism Ligands Molecular Imaging - methods Molecular Structure Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Peptidomimetics - chemical synthesis Peptidomimetics - chemistry Stereoisomerism
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