Assessment of Eptifibatide Clearance by Hemodialysis Using an in vitro System

Background/Aims: Eptifibatide is a parenteral glycoprotein IIb-IIIa inhibitor that prevents platelet aggregation. Although contraindicated in dialysis patients due to limited safety and dialysis data, eptifibatide is prescribed in this population and is associated with bleeding complications. This s...

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Veröffentlicht in:	Blood purification 2010-01, Vol.30 (4), p.266-271
Hauptverfasser:	Hudson, Joanna Q., McNeely, Elizabeth B., Green, Christie A., Jennings, Lisa K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Contraindications Creatinine - analysis Emergency and intensive care: renal failure. Dialysis management Equipment and Supplies - standards Hemodiafiltration - standards Hemodialysis Solutions - chemistry Hemorrhage - chemically induced Hemorrhage - therapy Humans In Vitro Techniques Infusions, Parenteral Intensive care medicine Medical sciences Original Paper Peptides - adverse effects Peptides - pharmacokinetics Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - adverse effects Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Urea - analysis
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