Progression of Segment-Specific Carotid Artery Intima-Media Thickness in Young Adults (from the Bogalusa Heart Study)
Carotid intima-media thickness (CIMT) progression is predictive of future cardiovascular events in middle-age and older adults. However, information is scant on segment-specific CIMT progression by race (black vs white) and gender and its predictors during short-term follow-up in asymptomatic young...
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| Veröffentlicht in: | The American journal of cardiology 2011, Vol.107 (1), p.114-119 |
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| creator | Nguyen, Quoc Manh, MD, MPH Toprak, Ahmet, MD Xu, Ji-Hua, MD Srinivasan, Sathanur R., PhD Chen, Wei, MD, PhD Berenson, Gerald S., MD |
| description | Carotid intima-media thickness (CIMT) progression is predictive of future cardiovascular events in middle-age and older adults. However, information is scant on segment-specific CIMT progression by race (black vs white) and gender and its predictors during short-term follow-up in asymptomatic young adults. B-mode ultrasound images of the far walls of both carotid arteries were obtained in 842 subjects aged 24 to 43 years and enrolled in the Bogalusa Heart Study (70% whites and 42% men). The CIMT and cardiometabolic risk variables were measured at baseline and after an average of 2.4 years. The mean CIMT progression rates/year adjusted for age, race, and gender were greatest at the bulb, followed by the internal and common carotid segments (p |
| doi_str_mv | 10.1016/j.amjcard.2010.08.054 |
| format | Article |
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However, information is scant on segment-specific CIMT progression by race (black vs white) and gender and its predictors during short-term follow-up in asymptomatic young adults. B-mode ultrasound images of the far walls of both carotid arteries were obtained in 842 subjects aged 24 to 43 years and enrolled in the Bogalusa Heart Study (70% whites and 42% men). The CIMT and cardiometabolic risk variables were measured at baseline and after an average of 2.4 years. The mean CIMT progression rates/year adjusted for age, race, and gender were greatest at the bulb, followed by the internal and common carotid segments (p <0.0001). In a multivariate logistic model, age, mean arterial pressure, and high-density lipoprotein cholesterol were significantly associated with common CIMT progression. Smoking, age, insulin resistance index, and mean arterial pressure were significantly associated with bulb CIMT progression; and the waist/height ratio, smoking, age, and mean arterial pressure were significantly associated with internal CIMT progression, independent of the baseline CIMT and traditional cardiometabolic risk variables, including adiponectin, C-reactive protein, and intercellular adhesion molecules. In addition, the status of progression was associated with a greater prevalence of metabolic syndrome (common and internal CIMT, p <0.05; bulb CIMT, p <0.0001) and diabetes (bulb CIMT only, p <0.001). In conclusion, in younger adults, the magnitude of progression of CIMT within a short period varied in a segment-specific manner, regardless of race or gender, and was predictable using modifiable traditional risk factors. This could have implications for preventive and interventional cardiology.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2010.08.054</identifier><identifier>PMID: 21146698</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Cardiology ; Cardiology. 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However, information is scant on segment-specific CIMT progression by race (black vs white) and gender and its predictors during short-term follow-up in asymptomatic young adults. B-mode ultrasound images of the far walls of both carotid arteries were obtained in 842 subjects aged 24 to 43 years and enrolled in the Bogalusa Heart Study (70% whites and 42% men). The CIMT and cardiometabolic risk variables were measured at baseline and after an average of 2.4 years. The mean CIMT progression rates/year adjusted for age, race, and gender were greatest at the bulb, followed by the internal and common carotid segments (p <0.0001). In a multivariate logistic model, age, mean arterial pressure, and high-density lipoprotein cholesterol were significantly associated with common CIMT progression. Smoking, age, insulin resistance index, and mean arterial pressure were significantly associated with bulb CIMT progression; and the waist/height ratio, smoking, age, and mean arterial pressure were significantly associated with internal CIMT progression, independent of the baseline CIMT and traditional cardiometabolic risk variables, including adiponectin, C-reactive protein, and intercellular adhesion molecules. In addition, the status of progression was associated with a greater prevalence of metabolic syndrome (common and internal CIMT, p <0.05; bulb CIMT, p <0.0001) and diabetes (bulb CIMT only, p <0.001). In conclusion, in younger adults, the magnitude of progression of CIMT within a short period varied in a segment-specific manner, regardless of race or gender, and was predictable using modifiable traditional risk factors. This could have implications for preventive and interventional cardiology.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate analysis</subject><subject>Predictive Value of Tests</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Veins & arteries</subject><subject>Young adults</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl-LEzEUxQdR3Lr6EZQgiPowNXcykz8vSi3qLqwodH3wKaRJppvuTFKTjNBvb0rrCvviU0j43ZN77zlV9RzwHDDQd9u5GrdaRTNvcHnDfI679kE1A85EDQLIw2qGMW5qAa04q56ktC1XgI4-rs4agJZSwWfV9D2GTbQpueBR6NHKbkbrc73aWe16p9FSxZCdQYuYbdyjS5_dqOqv1jiFrm-cvvWlGDmPfobJb9DCTENO6E0fw4jyjUUfw0YNU1LowqqY0SpPZv_2afWoV0Oyz07nefXj86fr5UV99e3L5XJxVeuubXKtmWGYrSnnuhdUGM2oIExwhgXj0CqlOiugIbgzqgFaGCOg00QJWBMChpxXr4-6uxh-TTZlObqk7TAob8OUJC-LEA0TbSFf3iO3YYq-NCc5CIZpx5oCdUdIx5BStL3cxbKNuJeA5cEVuZUnV-TBFYm5LK6Uuhcn8Wk9WnNX9deGArw6ASppNfRRee3SP44IiluOC_fhyNmytN_ORpm0s14XN6LVWZrg_tvK-3sKenDelU9v7d6mu6FBpkZiuTpE6JAgKNlhhFHyB64IwMA</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Nguyen, Quoc Manh, MD, MPH</creator><creator>Toprak, Ahmet, MD</creator><creator>Xu, Ji-Hua, MD</creator><creator>Srinivasan, Sathanur R., PhD</creator><creator>Chen, Wei, MD, PhD</creator><creator>Berenson, Gerald S., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Progression of Segment-Specific Carotid Artery Intima-Media Thickness in Young Adults (from the Bogalusa Heart Study)</title><author>Nguyen, Quoc Manh, MD, MPH ; Toprak, Ahmet, MD ; Xu, Ji-Hua, MD ; Srinivasan, Sathanur R., PhD ; Chen, Wei, MD, PhD ; Berenson, Gerald S., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-c7d707b688cf969dc76937987097814aaa5e912305da216f96d915c3a91b331d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate analysis</topic><topic>Predictive Value of Tests</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Veins & arteries</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Quoc Manh, MD, MPH</creatorcontrib><creatorcontrib>Toprak, Ahmet, MD</creatorcontrib><creatorcontrib>Xu, Ji-Hua, MD</creatorcontrib><creatorcontrib>Srinivasan, Sathanur R., PhD</creatorcontrib><creatorcontrib>Chen, Wei, MD, PhD</creatorcontrib><creatorcontrib>Berenson, Gerald S., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Quoc Manh, MD, MPH</au><au>Toprak, Ahmet, MD</au><au>Xu, Ji-Hua, MD</au><au>Srinivasan, Sathanur R., PhD</au><au>Chen, Wei, MD, PhD</au><au>Berenson, Gerald S., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progression of Segment-Specific Carotid Artery Intima-Media Thickness in Young Adults (from the Bogalusa Heart Study)</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2011</date><risdate>2011</risdate><volume>107</volume><issue>1</issue><spage>114</spage><epage>119</epage><pages>114-119</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Carotid intima-media thickness (CIMT) progression is predictive of future cardiovascular events in middle-age and older adults. However, information is scant on segment-specific CIMT progression by race (black vs white) and gender and its predictors during short-term follow-up in asymptomatic young adults. B-mode ultrasound images of the far walls of both carotid arteries were obtained in 842 subjects aged 24 to 43 years and enrolled in the Bogalusa Heart Study (70% whites and 42% men). The CIMT and cardiometabolic risk variables were measured at baseline and after an average of 2.4 years. The mean CIMT progression rates/year adjusted for age, race, and gender were greatest at the bulb, followed by the internal and common carotid segments (p <0.0001). In a multivariate logistic model, age, mean arterial pressure, and high-density lipoprotein cholesterol were significantly associated with common CIMT progression. Smoking, age, insulin resistance index, and mean arterial pressure were significantly associated with bulb CIMT progression; and the waist/height ratio, smoking, age, and mean arterial pressure were significantly associated with internal CIMT progression, independent of the baseline CIMT and traditional cardiometabolic risk variables, including adiponectin, C-reactive protein, and intercellular adhesion molecules. In addition, the status of progression was associated with a greater prevalence of metabolic syndrome (common and internal CIMT, p <0.05; bulb CIMT, p <0.0001) and diabetes (bulb CIMT only, p <0.001). In conclusion, in younger adults, the magnitude of progression of CIMT within a short period varied in a segment-specific manner, regardless of race or gender, and was predictable using modifiable traditional risk factors. This could have implications for preventive and interventional cardiology.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21146698</pmid><doi>10.1016/j.amjcard.2010.08.054</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Carotid Arteries - diagnostic imaging Female Follow-Up Studies Humans Male Medical sciences Multivariate analysis Predictive Value of Tests Risk Assessment Risk Factors Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonic imaging Ultrasonography Veins & arteries Young adults |
| title | Progression of Segment-Specific Carotid Artery Intima-Media Thickness in Young Adults (from the Bogalusa Heart Study) |
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