Paracetamol in early infancy: the risk of childhood allergy and asthma
Aim: We investigated whether paracetamol exposure in pregnancy and until 6 months of age was associated with allergic disease in school children. Methods: In a prospective birth cohort study in Oslo, 1016 children included at birth were re‐investigated at 10 years. Paracetamol exposure in pregnanc...
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| Veröffentlicht in: | Acta Paediatrica 2011-01, Vol.100 (1), p.90-96 |
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| creator | Bakkeheim, Egil Mowinckel, Peter Carlsen, Kai Håkon Håland, Geir Carlsen, Karin C Lødrup |
| description | Aim: We investigated whether paracetamol exposure in pregnancy and until 6 months of age was associated with allergic disease in school children.
Methods: In a prospective birth cohort study in Oslo, 1016 children included at birth were re‐investigated at 10 years. Paracetamol exposure in pregnancy and until 6 months of age was registered. Outcomes at 10 years included current asthma, a history of asthma, allergic sensitization and allergic rhinitis.
Results: Maternal paracetamol use in the first trimester increased the risk for allergic rhinitis at 10 years OR (odds ratio) (95%CI) 2.30 (1.06, 4.97) in boys and girls. Paracetamol use until 6 months in girls increased the risk for allergic sensitization OR 2.20 (1.15, 4.22) and a history of asthma OR 2.20 (1.13, 4.30). The ORs for allergic sensitization and history of asthma in girls remained unchanged adjusting for upper or lower airway infections during the first 6 months of life.
Conclusion: Paracetamol exposure in pregnancy was associated with allergic rhinitis, but not with asthma or allergic sensitization at 10 years of age. Paracetamol used until 6 months of age was associated with allergic sensitization and having a history of asthma in girls at 10 years of age, even considering concomitant airway infections. |
| doi_str_mv | 10.1111/j.1651-2227.2010.01942.x |
| format | Article |
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Methods: In a prospective birth cohort study in Oslo, 1016 children included at birth were re‐investigated at 10 years. Paracetamol exposure in pregnancy and until 6 months of age was registered. Outcomes at 10 years included current asthma, a history of asthma, allergic sensitization and allergic rhinitis.
Results: Maternal paracetamol use in the first trimester increased the risk for allergic rhinitis at 10 years OR (odds ratio) (95%CI) 2.30 (1.06, 4.97) in boys and girls. Paracetamol use until 6 months in girls increased the risk for allergic sensitization OR 2.20 (1.15, 4.22) and a history of asthma OR 2.20 (1.13, 4.30). The ORs for allergic sensitization and history of asthma in girls remained unchanged adjusting for upper or lower airway infections during the first 6 months of life.
Conclusion: Paracetamol exposure in pregnancy was associated with allergic rhinitis, but not with asthma or allergic sensitization at 10 years of age. Paracetamol used until 6 months of age was associated with allergic sensitization and having a history of asthma in girls at 10 years of age, even considering concomitant airway infections.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2010.01942.x</identifier><identifier>PMID: 21143295</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetaminophen - adverse effects ; Age ; Allergic sensitization ; Allergies ; Allergy ; Asthma ; Asthma - chemically induced ; Biological and medical sciences ; Child ; Chronic obstructive pulmonary disease, asthma ; Female ; Follow-Up Studies ; Gender ; General aspects ; Girls ; Histamine ; Humans ; Hypersensitivity - etiology ; Infant ; Male ; Medical sciences ; Paracetamol ; Pneumology ; Pregnancy ; Prenatal Exposure Delayed Effects - chemically induced ; Prospective Studies ; Risk</subject><ispartof>Acta Paediatrica, 2011-01, Vol.100 (1), p.90-96</ispartof><rights>2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Pædiatrica</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4642-8089d63f88b2e37aadbbc77e25e50274d963ecb125e77e981f68685950e62f633</citedby><cites>FETCH-LOGICAL-c4642-8089d63f88b2e37aadbbc77e25e50274d963ecb125e77e981f68685950e62f633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.2010.01942.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.2010.01942.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23652223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21143295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakkeheim, Egil</creatorcontrib><creatorcontrib>Mowinckel, Peter</creatorcontrib><creatorcontrib>Carlsen, Kai Håkon</creatorcontrib><creatorcontrib>Håland, Geir</creatorcontrib><creatorcontrib>Carlsen, Karin C Lødrup</creatorcontrib><title>Paracetamol in early infancy: the risk of childhood allergy and asthma</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim: We investigated whether paracetamol exposure in pregnancy and until 6 months of age was associated with allergic disease in school children.
Methods: In a prospective birth cohort study in Oslo, 1016 children included at birth were re‐investigated at 10 years. Paracetamol exposure in pregnancy and until 6 months of age was registered. Outcomes at 10 years included current asthma, a history of asthma, allergic sensitization and allergic rhinitis.
Results: Maternal paracetamol use in the first trimester increased the risk for allergic rhinitis at 10 years OR (odds ratio) (95%CI) 2.30 (1.06, 4.97) in boys and girls. Paracetamol use until 6 months in girls increased the risk for allergic sensitization OR 2.20 (1.15, 4.22) and a history of asthma OR 2.20 (1.13, 4.30). The ORs for allergic sensitization and history of asthma in girls remained unchanged adjusting for upper or lower airway infections during the first 6 months of life.
Conclusion: Paracetamol exposure in pregnancy was associated with allergic rhinitis, but not with asthma or allergic sensitization at 10 years of age. Paracetamol used until 6 months of age was associated with allergic sensitization and having a history of asthma in girls at 10 years of age, even considering concomitant airway infections.</description><subject>Acetaminophen - adverse effects</subject><subject>Age</subject><subject>Allergic sensitization</subject><subject>Allergies</subject><subject>Allergy</subject><subject>Asthma</subject><subject>Asthma - chemically induced</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gender</subject><subject>General aspects</subject><subject>Girls</subject><subject>Histamine</subject><subject>Humans</subject><subject>Hypersensitivity - etiology</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Paracetamol</subject><subject>Pneumology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prospective Studies</subject><subject>Risk</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF9P2zAUxS20CTq2rzBZmiaeUvzfzqQ9FEZhgm08DCHxYjmOs6Y4CdipaL79nLV0Ek_4xdfXv3N9fACAGE1xWsfLKRYcZ4QQOSUodRHOGZmu98Bkd_EGTJBCNOOE0wPwLsYlQoTmTOyDA4IxoyTnEzC_NsFY15um87BuoTPBD6moTGuHL7BfOBjqeA-7CtpF7ctF15XQeO_CnwGaNtWxXzTmPXhbGR_dh-1-CG7mZ79PL7KrX-ffT2dXmWWCkUwhlZeCVkoVxFFpTFkUVkpHuOOISFbmgjpb4HRO3VzhSiiheM6RE6QSlB6Co83ch9A9rlzsdVNH67w3retWUav0s5xIPJKfXpDLbhXaZE5jzpiSlDCZKLWhbOhiDK7SD6FuTBg0RnqMWi_1mKgeE9Vj1Ppf1HqdpB-3D6yKxpU74XO2Cfi8BUy0xlchRVrH_xwVPE0dnX7dcE-1d8OrDejZ9Wyskj7b6OvYu_VOb8K9FpJKrm9_nutv7PbH3fzyRM_pX5YOpiw</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Bakkeheim, Egil</creator><creator>Mowinckel, Peter</creator><creator>Carlsen, Kai Håkon</creator><creator>Håland, Geir</creator><creator>Carlsen, Karin C Lødrup</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Paracetamol in early infancy: the risk of childhood allergy and asthma</title><author>Bakkeheim, Egil ; Mowinckel, Peter ; Carlsen, Kai Håkon ; Håland, Geir ; Carlsen, Karin C Lødrup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4642-8089d63f88b2e37aadbbc77e25e50274d963ecb125e77e981f68685950e62f633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetaminophen - adverse effects</topic><topic>Age</topic><topic>Allergic sensitization</topic><topic>Allergies</topic><topic>Allergy</topic><topic>Asthma</topic><topic>Asthma - chemically induced</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gender</topic><topic>General aspects</topic><topic>Girls</topic><topic>Histamine</topic><topic>Humans</topic><topic>Hypersensitivity - etiology</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Paracetamol</topic><topic>Pneumology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prospective Studies</topic><topic>Risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakkeheim, Egil</creatorcontrib><creatorcontrib>Mowinckel, Peter</creatorcontrib><creatorcontrib>Carlsen, Kai Håkon</creatorcontrib><creatorcontrib>Håland, Geir</creatorcontrib><creatorcontrib>Carlsen, Karin C Lødrup</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakkeheim, Egil</au><au>Mowinckel, Peter</au><au>Carlsen, Kai Håkon</au><au>Håland, Geir</au><au>Carlsen, Karin C Lødrup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paracetamol in early infancy: the risk of childhood allergy and asthma</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2011-01</date><risdate>2011</risdate><volume>100</volume><issue>1</issue><spage>90</spage><epage>96</epage><pages>90-96</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim: We investigated whether paracetamol exposure in pregnancy and until 6 months of age was associated with allergic disease in school children.
Methods: In a prospective birth cohort study in Oslo, 1016 children included at birth were re‐investigated at 10 years. Paracetamol exposure in pregnancy and until 6 months of age was registered. Outcomes at 10 years included current asthma, a history of asthma, allergic sensitization and allergic rhinitis.
Results: Maternal paracetamol use in the first trimester increased the risk for allergic rhinitis at 10 years OR (odds ratio) (95%CI) 2.30 (1.06, 4.97) in boys and girls. Paracetamol use until 6 months in girls increased the risk for allergic sensitization OR 2.20 (1.15, 4.22) and a history of asthma OR 2.20 (1.13, 4.30). The ORs for allergic sensitization and history of asthma in girls remained unchanged adjusting for upper or lower airway infections during the first 6 months of life.
Conclusion: Paracetamol exposure in pregnancy was associated with allergic rhinitis, but not with asthma or allergic sensitization at 10 years of age. Paracetamol used until 6 months of age was associated with allergic sensitization and having a history of asthma in girls at 10 years of age, even considering concomitant airway infections.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21143295</pmid><doi>10.1111/j.1651-2227.2010.01942.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetaminophen - adverse effects Age Allergic sensitization Allergies Allergy Asthma Asthma - chemically induced Biological and medical sciences Child Chronic obstructive pulmonary disease, asthma Female Follow-Up Studies Gender General aspects Girls Histamine Humans Hypersensitivity - etiology Infant Male Medical sciences Paracetamol Pneumology Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prospective Studies Risk |
| title | Paracetamol in early infancy: the risk of childhood allergy and asthma |
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