Radioisotope studies of purine metabolism during administration of guanine and allopurinol in the pig

In pigs pre-fed guanine, some 33 per cent of [8- 14C]guanine administered orally appeared in the urine in 24 hr, principally in the form of allantoin. Little incorporation (less than 1 per cent) of radioactivity into body tissues occurred and only 5 per cent of the radioactivity could be found in th...

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Veröffentlicht in:	Biochemical pharmacology 1973-10, Vol.22 (20), p.2553-2558
Hauptverfasser:	Simmonds, H.Anne, Rising, Trevor J., Cadenhead, Andrew, Hatfield, Peter J., Jones, Arthur S., Cameron, J.Stewart
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allopurinol - pharmacology Animals Carbon Radioisotopes Feces - metabolism Guanine - pharmacology Injections, Intravenous Nucleic Acids - metabolism Pteridines - pharmacology Purines - metabolism Pyrimidines - pharmacology Swine Time Factors
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