Ultrastructural Changes in the Chlamydia-Infected Ileal Mucosa of Newborn Calves
Ultrastructural changes induced by chlamydial infection of mucosal cells of the ileum of newborn calves after oral inoculation were investigated. Depending on the stage of chlamydial development, the organelles of all infected cells became damaged. The damage was degenerative and included vesiculati...
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| Veröffentlicht in: | Veterinary pathology 1973-01, Vol.10 (2), p.114-123 |
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| container_title | Veterinary pathology |
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| creator | Doughri, A. M. Altera, K. P. Storz, J. Eugster, A. K. |
| description | Ultrastructural changes induced by chlamydial infection of mucosal cells of the ileum of newborn calves after oral inoculation were investigated. Depending on the stage of chlamydial development, the organelles of all infected cells became damaged. The damage was degenerative and included vesiculation of microvilli and swelling of the terminal web of absorptive epithelial cells. The mitochondria were swollen and had fragmented cristae. The endoplasmie reticulum was dilated and vesiculated, and infected cells gradually lost their ribosomes. The lateral junctional complex between infected cells became occasionally dislocated and fragmented. The basal lamina was thrown into folds, became discontinuous and separated from the basal border of the epithelial cells. The nuclei of infected cells were affected last, lost their chromatin pattern, and ultimately became pyknotic. |
| doi_str_mv | 10.1177/030098587301000204 |
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The nuclei of infected cells were affected last, lost their chromatin pattern, and ultimately became pyknotic.</description><identifier>ISSN: 0300-9858</identifier><identifier>EISSN: 1544-2217</identifier><identifier>DOI: 10.1177/030098587301000204</identifier><identifier>PMID: 4768407</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Animals, Newborn ; Cattle ; Cattle Diseases - pathology ; Chlamydia Infections - pathology ; Chlamydia Infections - veterinary ; Endoplasmic Reticulum ; Ileum - pathology ; Intercellular Junctions ; Intestinal Mucosa - pathology ; Microscopy, Electron ; Mitochondrial Swelling ; Ribosomes</subject><ispartof>Veterinary pathology, 1973-01, Vol.10 (2), p.114-123</ispartof><rights>1973 American College of Veterinary Pathologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-81badd6897a8781bee983ed195f348390fc51990449bed0e7a356e0a577932443</citedby><cites>FETCH-LOGICAL-c382t-81badd6897a8781bee983ed195f348390fc51990449bed0e7a356e0a577932443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/030098587301000204$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/030098587301000204$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4768407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doughri, A. M.</creatorcontrib><creatorcontrib>Altera, K. P.</creatorcontrib><creatorcontrib>Storz, J.</creatorcontrib><creatorcontrib>Eugster, A. K.</creatorcontrib><title>Ultrastructural Changes in the Chlamydia-Infected Ileal Mucosa of Newborn Calves</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Ultrastructural changes induced by chlamydial infection of mucosal cells of the ileum of newborn calves after oral inoculation were investigated. Depending on the stage of chlamydial development, the organelles of all infected cells became damaged. The damage was degenerative and included vesiculation of microvilli and swelling of the terminal web of absorptive epithelial cells. The mitochondria were swollen and had fragmented cristae. The endoplasmie reticulum was dilated and vesiculated, and infected cells gradually lost their ribosomes. The lateral junctional complex between infected cells became occasionally dislocated and fragmented. The basal lamina was thrown into folds, became discontinuous and separated from the basal border of the epithelial cells. The nuclei of infected cells were affected last, lost their chromatin pattern, and ultimately became pyknotic.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cattle</subject><subject>Cattle Diseases - pathology</subject><subject>Chlamydia Infections - pathology</subject><subject>Chlamydia Infections - veterinary</subject><subject>Endoplasmic Reticulum</subject><subject>Ileum - pathology</subject><subject>Intercellular Junctions</subject><subject>Intestinal Mucosa - pathology</subject><subject>Microscopy, Electron</subject><subject>Mitochondrial Swelling</subject><subject>Ribosomes</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRaq3-AUHIyl3snUc6M0sJPgr1sbDrMElu2pRJUmcSpf_eKS1uBFeXw_nOgXsIuaZwR6mUU-AAWiVKcqAAwECckDFNhIgZo_KUjPdAvCfOyYX3m4AwreSIjIScKQFyTN6XtnfG924o-sEZG6Vr067QR3Ub9WsM0ppmV9YmnrcVFj2W0dxi4F6GovMm6qroFb_zzrVRauwX-ktyVhnr8ep4J2T5-PCRPseLt6d5er-IC65YHyuam7KcKS2NkkEgasWxpDqpuFBcQ1UkVGsQQudYAkrDkxmCSaTUnAnBJ-T20Lt13eeAvs-a2hdorWmxG3ymGKUguQ4gO4CF67x3WGVbVzfG7TIK2X7G7O-MIXRzbB_yBsvfyHG34E8PvjcrzDbd4Nrw7H-NP9fWeSg</recordid><startdate>19730101</startdate><enddate>19730101</enddate><creator>Doughri, A. M.</creator><creator>Altera, K. P.</creator><creator>Storz, J.</creator><creator>Eugster, A. K.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19730101</creationdate><title>Ultrastructural Changes in the Chlamydia-Infected Ileal Mucosa of Newborn Calves</title><author>Doughri, A. M. ; Altera, K. P. ; Storz, J. ; Eugster, A. 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K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doughri, A. M.</au><au>Altera, K. P.</au><au>Storz, J.</au><au>Eugster, A. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural Changes in the Chlamydia-Infected Ileal Mucosa of Newborn Calves</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>1973-01-01</date><risdate>1973</risdate><volume>10</volume><issue>2</issue><spage>114</spage><epage>123</epage><pages>114-123</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Ultrastructural changes induced by chlamydial infection of mucosal cells of the ileum of newborn calves after oral inoculation were investigated. Depending on the stage of chlamydial development, the organelles of all infected cells became damaged. The damage was degenerative and included vesiculation of microvilli and swelling of the terminal web of absorptive epithelial cells. The mitochondria were swollen and had fragmented cristae. The endoplasmie reticulum was dilated and vesiculated, and infected cells gradually lost their ribosomes. The lateral junctional complex between infected cells became occasionally dislocated and fragmented. The basal lamina was thrown into folds, became discontinuous and separated from the basal border of the epithelial cells. The nuclei of infected cells were affected last, lost their chromatin pattern, and ultimately became pyknotic.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>4768407</pmid><doi>10.1177/030098587301000204</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9858 |
| ispartof | Veterinary pathology, 1973-01, Vol.10 (2), p.114-123 |
| issn | 0300-9858 1544-2217 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82110739 |
| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Animals Animals, Newborn Cattle Cattle Diseases - pathology Chlamydia Infections - pathology Chlamydia Infections - veterinary Endoplasmic Reticulum Ileum - pathology Intercellular Junctions Intestinal Mucosa - pathology Microscopy, Electron Mitochondrial Swelling Ribosomes |
| title | Ultrastructural Changes in the Chlamydia-Infected Ileal Mucosa of Newborn Calves |
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