Leukemia. VIII. Leukemogenic Effect of Brain Filtrates After Serial Passage Through Mice.
Summary 1. Cell-free filtrates of leukemic AKR and Swiss mouse and human brains were prepared. 2. The filtrates were serially passed through Swiss mice in the case of AKR mouse and human brains and through C3Heb mice in the case of Swiss mice. 3. After 5 passages leukemogenic activity could be demon...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1958-02, Vol.97 (2), p.397-399 |
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| container_end_page | 399 |
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| container_issue | 2 |
| container_start_page | 397 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 97 |
| creator | Schwartz, Steven O. Schoolman, Harold M. Spurrier, Wilma Yates, LeRoy |
| description | Summary
1. Cell-free filtrates of leukemic AKR and Swiss mouse and human brains were prepared. 2. The filtrates were serially passed through Swiss mice in the case of AKR mouse and human brains and through C3Heb mice in the case of Swiss mice. 3. After 5 passages leukemogenic activity could be demonstrated by reintroduction of the material into the starting strain in case of the mice, and into AKR mice in case of human brains. 4. No activity or little activity could be demonstrated when leukemic tissues served as sources of the original material. 5. The experiments demonstrate that the activity of the material is not dependent on cells. 6. The dilution resulting from the passages described is such as to compel the assumption that the activity has been replicated. |
| doi_str_mv | 10.3181/00379727-97-23753 |
| format | Article |
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1. Cell-free filtrates of leukemic AKR and Swiss mouse and human brains were prepared. 2. The filtrates were serially passed through Swiss mice in the case of AKR mouse and human brains and through C3Heb mice in the case of Swiss mice. 3. After 5 passages leukemogenic activity could be demonstrated by reintroduction of the material into the starting strain in case of the mice, and into AKR mice in case of human brains. 4. No activity or little activity could be demonstrated when leukemic tissues served as sources of the original material. 5. The experiments demonstrate that the activity of the material is not dependent on cells. 6. The dilution resulting from the passages described is such as to compel the assumption that the activity has been replicated.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-97-23753</identifier><identifier>PMID: 13518284</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Brain ; Filtration ; Leukemia ; Leukemia, Experimental ; Mice ; Old Medline ; Serial Passage</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1958-02, Vol.97 (2), p.397-399</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-b8a88807645ae2f2a849271b666c7147dc43c234131c23a864dafa314228dbd23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13518284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwartz, Steven O.</creatorcontrib><creatorcontrib>Schoolman, Harold M.</creatorcontrib><creatorcontrib>Spurrier, Wilma</creatorcontrib><creatorcontrib>Yates, LeRoy</creatorcontrib><title>Leukemia. VIII. Leukemogenic Effect of Brain Filtrates After Serial Passage Through Mice.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
1. Cell-free filtrates of leukemic AKR and Swiss mouse and human brains were prepared. 2. The filtrates were serially passed through Swiss mice in the case of AKR mouse and human brains and through C3Heb mice in the case of Swiss mice. 3. After 5 passages leukemogenic activity could be demonstrated by reintroduction of the material into the starting strain in case of the mice, and into AKR mice in case of human brains. 4. No activity or little activity could be demonstrated when leukemic tissues served as sources of the original material. 5. The experiments demonstrate that the activity of the material is not dependent on cells. 6. The dilution resulting from the passages described is such as to compel the assumption that the activity has been replicated.</description><subject>Animals</subject><subject>Brain</subject><subject>Filtration</subject><subject>Leukemia</subject><subject>Leukemia, Experimental</subject><subject>Mice</subject><subject>Old Medline</subject><subject>Serial Passage</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1958</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAWyQV-wS_ErsLEvVQqQikChIrCzHsduUPIqdLPh7ElLEjtVoNOdeaQ4AVxiFFAt8ixDlCSc8SHhAKI_oEZjiiEYBjZPkGEyHezAAE3Dm_Q4hHHESn4IJphEWRLApeF-Z7sNUhQrhW5qmIRz3ZmPqQsOFtUa3sLHwzqmihsuibJ1qjYcz2xoHX4wrVAmflfdqY-B665pus4WPhTbhBTixqvTm8jDPwetysZ4_BKun-3Q-WwWaRLQNMqGEEIjHLFKGWKIESwjHWRzHmmPGc82oJpRhivuhRMxyZRXFjBCRZzmh5-Bm7N275rMzvpVV4bUpS1WbpvNSEIwSFLMexCOoXeO9M1buXVEp9yUxkoNP-etTJlz--Owz14fyLqtM_pc4COyBcAQGAXLXdK7un_2n8RuPSnt_</recordid><startdate>195802</startdate><enddate>195802</enddate><creator>Schwartz, Steven O.</creator><creator>Schoolman, Harold M.</creator><creator>Spurrier, Wilma</creator><creator>Yates, LeRoy</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195802</creationdate><title>Leukemia. VIII. Leukemogenic Effect of Brain Filtrates After Serial Passage Through Mice.</title><author>Schwartz, Steven O. ; Schoolman, Harold M. ; Spurrier, Wilma ; Yates, LeRoy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-b8a88807645ae2f2a849271b666c7147dc43c234131c23a864dafa314228dbd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1958</creationdate><topic>Animals</topic><topic>Brain</topic><topic>Filtration</topic><topic>Leukemia</topic><topic>Leukemia, Experimental</topic><topic>Mice</topic><topic>Old Medline</topic><topic>Serial Passage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwartz, Steven O.</creatorcontrib><creatorcontrib>Schoolman, Harold M.</creatorcontrib><creatorcontrib>Spurrier, Wilma</creatorcontrib><creatorcontrib>Yates, LeRoy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwartz, Steven O.</au><au>Schoolman, Harold M.</au><au>Spurrier, Wilma</au><au>Yates, LeRoy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukemia. VIII. Leukemogenic Effect of Brain Filtrates After Serial Passage Through Mice.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1958-02</date><risdate>1958</risdate><volume>97</volume><issue>2</issue><spage>397</spage><epage>399</epage><pages>397-399</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
1. Cell-free filtrates of leukemic AKR and Swiss mouse and human brains were prepared. 2. The filtrates were serially passed through Swiss mice in the case of AKR mouse and human brains and through C3Heb mice in the case of Swiss mice. 3. After 5 passages leukemogenic activity could be demonstrated by reintroduction of the material into the starting strain in case of the mice, and into AKR mice in case of human brains. 4. No activity or little activity could be demonstrated when leukemic tissues served as sources of the original material. 5. The experiments demonstrate that the activity of the material is not dependent on cells. 6. The dilution resulting from the passages described is such as to compel the assumption that the activity has been replicated.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13518284</pmid><doi>10.3181/00379727-97-23753</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1958-02, Vol.97 (2), p.397-399 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82109064 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Brain Filtration Leukemia Leukemia, Experimental Mice Old Medline Serial Passage |
| title | Leukemia. VIII. Leukemogenic Effect of Brain Filtrates After Serial Passage Through Mice. |
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