Studies on Thiophene Derivatives. I. Syntheses of 2-Amino-1, 1-di (2-thienyl) alkanols

Studies on Thiophene Derivatives. I. Syntheses of 2-Amino-1, 1-di (2-thienyl) alkanols

It was found that 3-piperidino-1, 1-di (2-thienyl) butene prepared by Adamson possessed an antitussive action. The compound has one amino group at the 3-position, and one double bond between 1 and 2. However, ephedrine used as an antitussive for a long time has one amino group at 2-position and a hy...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1958/04/20, Vol.6(2), pp.159-163
Hauptverfasser: Kimura, Ryuichi, Yabuuchi, Takahiro, Tamura, Yasutaka
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Humans
Old Medline
Thiophenes
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container_title Chemical & pharmaceutical bulletin
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creator Kimura, Ryuichi
Yabuuchi, Takahiro
Tamura, Yasutaka
description It was found that 3-piperidino-1, 1-di (2-thienyl) butene prepared by Adamson possessed an antitussive action. The compound has one amino group at the 3-position, and one double bond between 1 and 2. However, ephedrine used as an antitussive for a long time has one amino group at 2-position and a hydroxyl group at 1-position. Therefore, 2-amino-1, 1-di (2-thienyl) propanols and 2-amino-1, 1-di (2-thienyl)-ethanols which have one amino group at 2-position and hydroxyl group at 1-position were synthesized, in order to investigate the structure-activity relationship of the antitussive. The compounds were synthesized by the condensation of 1-aminoalkane-1-carboxylic acid esters and thiophene (the lithium method).
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subjects Humans
Old Medline
Thiophenes
title Studies on Thiophene Derivatives. I. Syntheses of 2-Amino-1, 1-di (2-thienyl) alkanols
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