Pituitary adrenocortical activity and intermale aggressiveness in isolated mice
Three experiments were conducted to clarify the role of the hormones of the pituitary adrenocortical axis in the control of intermale aggressiveness in mice. The first experiment tested the possibility that adrenalectomy decreases aggressiveness through decreasing androgen levels by treating adrenal...
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| Veröffentlicht in: | Physiology & behavior 1973-11, Vol.11 (5), p.705-711 |
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| container_title | Physiology & behavior |
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| creator | Leshner, Alan I. Walker, William A. Johnson, Allan E. Kelling, James S. Kreisler, Scott J. Svare, Bruce B. |
| description | Three experiments were conducted to clarify the role of the hormones of the pituitary adrenocortical axis in the control of intermale aggressiveness in mice. The first experiment tested the possibility that adrenalectomy decreases aggressiveness through decreasing androgen levels by treating adrenalectomized mice with testosterone propionate. None of the dosages of testosterone used in this study were effective in restoring the aggressiveness of adrenalectomized mice. The second and third experiments examined whether manipulations of pituitary adrenocortical activity affect aggressiveness because of changes in ACTH levels or because of changes in circulating glucocorticoid levels. In the second experiment, dexamethasone treatment restored the aggressiveness of adrenalectomized mice; and in the third experiment, ACTH decreased the aggressiveness of both intact mice and mice with controlled levels of corticosterone and/or testosterone. These findings suggest that ACTH levels, rather than glucocorticoid levels, are the critical parameters in the control of aggressiveness by the hormones of the pituitary adrenocortical axis and that ACTH affects aggressiveness independently of its effects on either adrenocortical or gonadal activity. |
| doi_str_mv | 10.1016/0031-9384(73)90256-4 |
| format | Article |
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The first experiment tested the possibility that adrenalectomy decreases aggressiveness through decreasing androgen levels by treating adrenalectomized mice with testosterone propionate. None of the dosages of testosterone used in this study were effective in restoring the aggressiveness of adrenalectomized mice. The second and third experiments examined whether manipulations of pituitary adrenocortical activity affect aggressiveness because of changes in ACTH levels or because of changes in circulating glucocorticoid levels. In the second experiment, dexamethasone treatment restored the aggressiveness of adrenalectomized mice; and in the third experiment, ACTH decreased the aggressiveness of both intact mice and mice with controlled levels of corticosterone and/or testosterone. These findings suggest that ACTH levels, rather than glucocorticoid levels, are the critical parameters in the control of aggressiveness by the hormones of the pituitary adrenocortical axis and that ACTH affects aggressiveness independently of its effects on either adrenocortical or gonadal activity.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(73)90256-4</identifier><identifier>PMID: 4355944</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ACTH ; Adrenal Glands - physiology ; Adrenalectomy ; Adrenals ; Adrenocorticotropic Hormone - pharmacology ; Aggression ; Aggression - drug effects ; Animals ; Castration ; Corticosterone ; Corticosterone - blood ; Dexamethasone ; Dexamethasone - pharmacology ; Humans ; Male ; Mice ; Pituitary ; Pituitary Gland - physiology ; Pituitary-Adrenal System - drug effects ; Social Isolation ; Testosterone ; Testosterone - pharmacology</subject><ispartof>Physiology & behavior, 1973-11, Vol.11 (5), p.705-711</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-9613de0f46842d940713913b679069e9e2887077e2ae1fc5aab2decd71c6e82d3</citedby><cites>FETCH-LOGICAL-c357t-9613de0f46842d940713913b679069e9e2887077e2ae1fc5aab2decd71c6e82d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0031938473902564$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4355944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leshner, Alan I.</creatorcontrib><creatorcontrib>Walker, William A.</creatorcontrib><creatorcontrib>Johnson, Allan E.</creatorcontrib><creatorcontrib>Kelling, James S.</creatorcontrib><creatorcontrib>Kreisler, Scott J.</creatorcontrib><creatorcontrib>Svare, Bruce B.</creatorcontrib><title>Pituitary adrenocortical activity and intermale aggressiveness in isolated mice</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Three experiments were conducted to clarify the role of the hormones of the pituitary adrenocortical axis in the control of intermale aggressiveness in mice. The first experiment tested the possibility that adrenalectomy decreases aggressiveness through decreasing androgen levels by treating adrenalectomized mice with testosterone propionate. None of the dosages of testosterone used in this study were effective in restoring the aggressiveness of adrenalectomized mice. The second and third experiments examined whether manipulations of pituitary adrenocortical activity affect aggressiveness because of changes in ACTH levels or because of changes in circulating glucocorticoid levels. In the second experiment, dexamethasone treatment restored the aggressiveness of adrenalectomized mice; and in the third experiment, ACTH decreased the aggressiveness of both intact mice and mice with controlled levels of corticosterone and/or testosterone. These findings suggest that ACTH levels, rather than glucocorticoid levels, are the critical parameters in the control of aggressiveness by the hormones of the pituitary adrenocortical axis and that ACTH affects aggressiveness independently of its effects on either adrenocortical or gonadal activity.</description><subject>ACTH</subject><subject>Adrenal Glands - physiology</subject><subject>Adrenalectomy</subject><subject>Adrenals</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Aggression</subject><subject>Aggression - drug effects</subject><subject>Animals</subject><subject>Castration</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Dexamethasone</subject><subject>Dexamethasone - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Pituitary</subject><subject>Pituitary Gland - physiology</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Social Isolation</subject><subject>Testosterone</subject><subject>Testosterone - pharmacology</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLQzEQhYMotVb_gcJdiS6uJje5eWwEKb6gUBcK7kKaTEvkPjTJLfjvTW3p0tkMzJlzhvkQOif4hmDCbzGmpFRUsitBrxWual6yAzQmUtCyxuLjEI33K8foJMZPnIsyOkIjRutaMTZG81efBp9M-CmMC9D1tg_JW9MUxia_9inPO1f4LkFoTQOFWa0CxOjX0OWWhcLHvjEJXNF6C6foaGmaCGe7PkHvjw9v0-dyNn96md7PSktrkUrFCXWAl4xLVjnFsCBUEbrgQmGuQEElpcBCQGWALG1tzKJyYJ0gloOsHJ2gy23uV-i_B4hJtz5aaBrTQT9ELSsseZ1RTBDbLtrQxxhgqb-Cb_O_mmC94ag3kPQGkhZU_3HULNsudvnDogW3N-3AZf1uq0N-cu0h6Gg9dBacD2CTdr3__8Av0kGCnw</recordid><startdate>197311</startdate><enddate>197311</enddate><creator>Leshner, Alan I.</creator><creator>Walker, William A.</creator><creator>Johnson, Allan E.</creator><creator>Kelling, James S.</creator><creator>Kreisler, Scott J.</creator><creator>Svare, Bruce B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197311</creationdate><title>Pituitary adrenocortical activity and intermale aggressiveness in isolated mice</title><author>Leshner, Alan I. ; Walker, William A. ; Johnson, Allan E. ; Kelling, James S. ; Kreisler, Scott J. ; Svare, Bruce B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-9613de0f46842d940713913b679069e9e2887077e2ae1fc5aab2decd71c6e82d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>ACTH</topic><topic>Adrenal Glands - physiology</topic><topic>Adrenalectomy</topic><topic>Adrenals</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Aggression</topic><topic>Aggression - drug effects</topic><topic>Animals</topic><topic>Castration</topic><topic>Corticosterone</topic><topic>Corticosterone - blood</topic><topic>Dexamethasone</topic><topic>Dexamethasone - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Pituitary</topic><topic>Pituitary Gland - physiology</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Social Isolation</topic><topic>Testosterone</topic><topic>Testosterone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leshner, Alan I.</creatorcontrib><creatorcontrib>Walker, William A.</creatorcontrib><creatorcontrib>Johnson, Allan E.</creatorcontrib><creatorcontrib>Kelling, James S.</creatorcontrib><creatorcontrib>Kreisler, Scott J.</creatorcontrib><creatorcontrib>Svare, Bruce B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leshner, Alan I.</au><au>Walker, William A.</au><au>Johnson, Allan E.</au><au>Kelling, James S.</au><au>Kreisler, Scott J.</au><au>Svare, Bruce B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pituitary adrenocortical activity and intermale aggressiveness in isolated mice</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1973-11</date><risdate>1973</risdate><volume>11</volume><issue>5</issue><spage>705</spage><epage>711</epage><pages>705-711</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Three experiments were conducted to clarify the role of the hormones of the pituitary adrenocortical axis in the control of intermale aggressiveness in mice. The first experiment tested the possibility that adrenalectomy decreases aggressiveness through decreasing androgen levels by treating adrenalectomized mice with testosterone propionate. None of the dosages of testosterone used in this study were effective in restoring the aggressiveness of adrenalectomized mice. The second and third experiments examined whether manipulations of pituitary adrenocortical activity affect aggressiveness because of changes in ACTH levels or because of changes in circulating glucocorticoid levels. In the second experiment, dexamethasone treatment restored the aggressiveness of adrenalectomized mice; and in the third experiment, ACTH decreased the aggressiveness of both intact mice and mice with controlled levels of corticosterone and/or testosterone. These findings suggest that ACTH levels, rather than glucocorticoid levels, are the critical parameters in the control of aggressiveness by the hormones of the pituitary adrenocortical axis and that ACTH affects aggressiveness independently of its effects on either adrenocortical or gonadal activity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4355944</pmid><doi>10.1016/0031-9384(73)90256-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Physiology & behavior, 1973-11, Vol.11 (5), p.705-711 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ACTH Adrenal Glands - physiology Adrenalectomy Adrenals Adrenocorticotropic Hormone - pharmacology Aggression Aggression - drug effects Animals Castration Corticosterone Corticosterone - blood Dexamethasone Dexamethasone - pharmacology Humans Male Mice Pituitary Pituitary Gland - physiology Pituitary-Adrenal System - drug effects Social Isolation Testosterone Testosterone - pharmacology |
| title | Pituitary adrenocortical activity and intermale aggressiveness in isolated mice |
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