Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients
Recent research suggests that 1,25-dihydroxyvitamin D [1,25(OH)₂D], a steroid hormone that regulates calcium homeostasis, may also play a role in the development and progression of cancer, multiple sclerosis, cardiovascular, and other diseases. Decreased serum 1,25(OH)₂D concentrations are often obs...
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| creator | Lagunova, Zoya Porojnicu, Alina C Vieth, Reinhold Lindberg, Fedon A Hexeberg, Sofie Moan, Johan |
| description | Recent research suggests that 1,25-dihydroxyvitamin D [1,25(OH)₂D], a steroid hormone that regulates calcium homeostasis, may also play a role in the development and progression of cancer, multiple sclerosis, cardiovascular, and other diseases. Decreased serum 1,25(OH)₂D concentrations are often observed in overweight and obese patients. However, little is known about the factors that may influence 1,25(OH)₂D renal synthesis, because it is generally accepted that serum 1,25(OH)₂D concentration is strictly regulated by parathyroid hormone and serum concentrations of calcium and phosphorus. In this study, the associations among serum 1,25(OH)₂D, serum 25-hydroxyvitamin D [25(OH)D], and body composition were analyzed in 1779 patients with excess body weight registered in a Metabolic and Medical Lifestyle Management Clinic in Oslo, Norway. According to our results, serum 25(OH)D, adiposity, age, season of blood sampling, and gender directly influence serum 1,25(OH)₂D (r = 0.33; P < 0.001), with serum 25(OH)D being the strongest predictor for serum 1,25(OH)₂D. The 1,25(OH)₂D concentrations were 25.4 pmol/L (95% Cl: 19.3-31.5; P < 0.001) lower in the lowest 25(OH)D quartile to compared with highest quartile. A seasonal variation was observed for both vitamin D metabolites. Thus, our results suggest that in patients with excess body weight, serum 1,25(OH)₂D concentrations were associated with 25(OH)D and varied during the year. Therefore, it may also be valuable to measure both serum 25(OH)D and 1,25(OH)₂D for the evaluation of vitamin D status in overweight and obese persons. |
| doi_str_mv | 10.3945/jn.109.119495 |
| format | Article |
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Decreased serum 1,25(OH)₂D concentrations are often observed in overweight and obese patients. However, little is known about the factors that may influence 1,25(OH)₂D renal synthesis, because it is generally accepted that serum 1,25(OH)₂D concentration is strictly regulated by parathyroid hormone and serum concentrations of calcium and phosphorus. In this study, the associations among serum 1,25(OH)₂D, serum 25-hydroxyvitamin D [25(OH)D], and body composition were analyzed in 1779 patients with excess body weight registered in a Metabolic and Medical Lifestyle Management Clinic in Oslo, Norway. According to our results, serum 25(OH)D, adiposity, age, season of blood sampling, and gender directly influence serum 1,25(OH)₂D (r = 0.33; P < 0.001), with serum 25(OH)D being the strongest predictor for serum 1,25(OH)₂D. The 1,25(OH)₂D concentrations were 25.4 pmol/L (95% Cl: 19.3-31.5; P < 0.001) lower in the lowest 25(OH)D quartile to compared with highest quartile. A seasonal variation was observed for both vitamin D metabolites. Thus, our results suggest that in patients with excess body weight, serum 1,25(OH)₂D concentrations were associated with 25(OH)D and varied during the year. Therefore, it may also be valuable to measure both serum 25(OH)D and 1,25(OH)₂D for the evaluation of vitamin D status in overweight and obese persons.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.3945/jn.109.119495</identifier><identifier>PMID: 21084655</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>1,25-dihydroxyvitamin D ; 25-hydroxycholecalciferol ; 25-hydroxyergocalciferol ; Adult ; Aged ; biochemical pathways ; Biological and medical sciences ; blood chemistry ; body composition ; body fat ; Body Mass Index ; calcium ; dietary minerals ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; gender differences ; Humans ; Male ; Medical sciences ; men ; Metabolic diseases ; metabolites ; Middle Aged ; nutritional status ; Obesity ; Obesity - blood ; overweight ; Overweight - blood ; parathyroid hormone ; patients ; phosphorus ; seasonal variation ; Seasons ; steroid hormones ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; women</subject><ispartof>The Journal of nutrition, 2011, Vol.141 (1), p.112-117</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-27726fb79598858bf8e8b004ca012d1ad5adb8aab78cfa9671270d1d8e869c9a3</citedby><cites>FETCH-LOGICAL-c484t-27726fb79598858bf8e8b004ca012d1ad5adb8aab78cfa9671270d1d8e869c9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23711190$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21084655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lagunova, Zoya</creatorcontrib><creatorcontrib>Porojnicu, Alina C</creatorcontrib><creatorcontrib>Vieth, Reinhold</creatorcontrib><creatorcontrib>Lindberg, Fedon A</creatorcontrib><creatorcontrib>Hexeberg, Sofie</creatorcontrib><creatorcontrib>Moan, Johan</creatorcontrib><title>Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Recent research suggests that 1,25-dihydroxyvitamin D [1,25(OH)₂D], a steroid hormone that regulates calcium homeostasis, may also play a role in the development and progression of cancer, multiple sclerosis, cardiovascular, and other diseases. Decreased serum 1,25(OH)₂D concentrations are often observed in overweight and obese patients. However, little is known about the factors that may influence 1,25(OH)₂D renal synthesis, because it is generally accepted that serum 1,25(OH)₂D concentration is strictly regulated by parathyroid hormone and serum concentrations of calcium and phosphorus. In this study, the associations among serum 1,25(OH)₂D, serum 25-hydroxyvitamin D [25(OH)D], and body composition were analyzed in 1779 patients with excess body weight registered in a Metabolic and Medical Lifestyle Management Clinic in Oslo, Norway. According to our results, serum 25(OH)D, adiposity, age, season of blood sampling, and gender directly influence serum 1,25(OH)₂D (r = 0.33; P < 0.001), with serum 25(OH)D being the strongest predictor for serum 1,25(OH)₂D. The 1,25(OH)₂D concentrations were 25.4 pmol/L (95% Cl: 19.3-31.5; P < 0.001) lower in the lowest 25(OH)D quartile to compared with highest quartile. A seasonal variation was observed for both vitamin D metabolites. Thus, our results suggest that in patients with excess body weight, serum 1,25(OH)₂D concentrations were associated with 25(OH)D and varied during the year. Therefore, it may also be valuable to measure both serum 25(OH)D and 1,25(OH)₂D for the evaluation of vitamin D status in overweight and obese persons.</description><subject>1,25-dihydroxyvitamin D</subject><subject>25-hydroxycholecalciferol</subject><subject>25-hydroxyergocalciferol</subject><subject>Adult</subject><subject>Aged</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>body composition</subject><subject>body fat</subject><subject>Body Mass Index</subject><subject>calcium</subject><subject>dietary minerals</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gender differences</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>men</subject><subject>Metabolic diseases</subject><subject>metabolites</subject><subject>Middle Aged</subject><subject>nutritional status</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>overweight</subject><subject>Overweight - blood</subject><subject>parathyroid hormone</subject><subject>patients</subject><subject>phosphorus</subject><subject>seasonal variation</subject><subject>Seasons</subject><subject>steroid hormones</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>women</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALgehSOHIFXxA9kGXGib-OVQttpUpbqfQcTWKn9WqTFDtb2H-Pqywg9dDLzBwevYd5GXuPsCxtJb-uhyWCXSLaysoXbIGywkIhwEu2ABCiKFGpA_YmpTUAYGXNa3YgEEylpFyw9bWP254LWZzvXBx_7x7CRH0Y-Cm_SJz4VfQutNMY-djx2eKXrE_D3VOfx-rBx18-3N5NnAbHV41Pnl_RFPwwpbfsVUeb5N_t9yG7-f7tx8l5cbk6uzg5vizaylRTIbQWqmu0ldYYaZrOeNMAVC0BCofkJLnGEDXatB1ZpVFocOgyU7a1VB6yz3PufRx_bn2a6j6k1m82NPhxm2ojQFutrMry6FmJgCjAKnikxUzbOKYUfVffx9BT3GVUPxZRr4d82nouIvsP--ht03v3T__9fAaf9oBSS5su0tCG9N-VGnMUZPdxdh2NNd3GbG6uBWAJaAWWZVX-AaXzmBE</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Lagunova, Zoya</creator><creator>Porojnicu, Alina C</creator><creator>Vieth, Reinhold</creator><creator>Lindberg, Fedon A</creator><creator>Hexeberg, Sofie</creator><creator>Moan, Johan</creator><general>American Society for Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients</title><author>Lagunova, Zoya ; Porojnicu, Alina C ; Vieth, Reinhold ; Lindberg, Fedon A ; Hexeberg, Sofie ; Moan, Johan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-27726fb79598858bf8e8b004ca012d1ad5adb8aab78cfa9671270d1d8e869c9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>1,25-dihydroxyvitamin D</topic><topic>25-hydroxycholecalciferol</topic><topic>25-hydroxyergocalciferol</topic><topic>Adult</topic><topic>Aged</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>body composition</topic><topic>body fat</topic><topic>Body Mass Index</topic><topic>calcium</topic><topic>dietary minerals</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gender differences</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>men</topic><topic>Metabolic diseases</topic><topic>metabolites</topic><topic>Middle Aged</topic><topic>nutritional status</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>overweight</topic><topic>Overweight - blood</topic><topic>parathyroid hormone</topic><topic>patients</topic><topic>phosphorus</topic><topic>seasonal variation</topic><topic>Seasons</topic><topic>steroid hormones</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lagunova, Zoya</creatorcontrib><creatorcontrib>Porojnicu, Alina C</creatorcontrib><creatorcontrib>Vieth, Reinhold</creatorcontrib><creatorcontrib>Lindberg, Fedon A</creatorcontrib><creatorcontrib>Hexeberg, Sofie</creatorcontrib><creatorcontrib>Moan, Johan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lagunova, Zoya</au><au>Porojnicu, Alina C</au><au>Vieth, Reinhold</au><au>Lindberg, Fedon A</au><au>Hexeberg, Sofie</au><au>Moan, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2011</date><risdate>2011</risdate><volume>141</volume><issue>1</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Recent research suggests that 1,25-dihydroxyvitamin D [1,25(OH)₂D], a steroid hormone that regulates calcium homeostasis, may also play a role in the development and progression of cancer, multiple sclerosis, cardiovascular, and other diseases. Decreased serum 1,25(OH)₂D concentrations are often observed in overweight and obese patients. However, little is known about the factors that may influence 1,25(OH)₂D renal synthesis, because it is generally accepted that serum 1,25(OH)₂D concentration is strictly regulated by parathyroid hormone and serum concentrations of calcium and phosphorus. In this study, the associations among serum 1,25(OH)₂D, serum 25-hydroxyvitamin D [25(OH)D], and body composition were analyzed in 1779 patients with excess body weight registered in a Metabolic and Medical Lifestyle Management Clinic in Oslo, Norway. According to our results, serum 25(OH)D, adiposity, age, season of blood sampling, and gender directly influence serum 1,25(OH)₂D (r = 0.33; P < 0.001), with serum 25(OH)D being the strongest predictor for serum 1,25(OH)₂D. The 1,25(OH)₂D concentrations were 25.4 pmol/L (95% Cl: 19.3-31.5; P < 0.001) lower in the lowest 25(OH)D quartile to compared with highest quartile. A seasonal variation was observed for both vitamin D metabolites. Thus, our results suggest that in patients with excess body weight, serum 1,25(OH)₂D concentrations were associated with 25(OH)D and varied during the year. Therefore, it may also be valuable to measure both serum 25(OH)D and 1,25(OH)₂D for the evaluation of vitamin D status in overweight and obese persons.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>21084655</pmid><doi>10.3945/jn.109.119495</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1,25-dihydroxyvitamin D 25-hydroxycholecalciferol 25-hydroxyergocalciferol Adult Aged biochemical pathways Biological and medical sciences blood chemistry body composition body fat Body Mass Index calcium dietary minerals Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology gender differences Humans Male Medical sciences men Metabolic diseases metabolites Middle Aged nutritional status Obesity Obesity - blood overweight Overweight - blood parathyroid hormone patients phosphorus seasonal variation Seasons steroid hormones Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D - analogs & derivatives Vitamin D - blood women |
| title | Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients |
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