The long journey of salicylates in ulcerative colitis: The past and the future

The long journey of salicylates in ulcerative colitis: The past and the future

The advent of salicylates in the treatment of ulcerative colitis started in 1938 with the discovery of Salazopyrin by Nanna Svartz. This drug offered for the first time a therapeutic chance to patients with ulcerative colitis. In this paper we describe the fascinating history of Salazopyrin and sali...

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Veröffentlicht in:Journal of Crohn's and colitis 2009-09, Vol.3 (3), p.149-156
Hauptverfasser: Caprilli, Renzo, Cesarini, Monica, Angelucci, Erika, Frieri, Giuseppe
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container_title Journal of Crohn's and colitis
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creator Caprilli, Renzo
Cesarini, Monica
Angelucci, Erika
Frieri, Giuseppe
description The advent of salicylates in the treatment of ulcerative colitis started in 1938 with the discovery of Salazopyrin by Nanna Svartz. This drug offered for the first time a therapeutic chance to patients with ulcerative colitis. In this paper we describe the fascinating history of Salazopyrin and salicylates from the first serendipitous observations to the last randomized clinical trials. Attention was paid to the pharmacokinetics and the mechanism of action of 5-aminosalicylates and, in particular, to the issue of the mucosal concentrations of 5-aminosalicylates and its therapeutic efficacy. Moreover a look at the new oral mesalazine formulations that allow the homogenous distribution of 5-aminosalicylate through all the large bowel was taken. Lastly, the possible use of mesalazine in the prevention of colorectal cancer was reviewed.
doi_str_mv 10.1016/j.crohns.2009.05.001
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title The long journey of salicylates in ulcerative colitis: The past and the future
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