A pilot study on potency determination of human follicle-stimulating hormone: A comparison between reversed-phase high-performance liquid chromatography method and the in vivo bioassay

Reversed-phase high-performance liquid chromatography (RP-HPLC) was compared with the classical Steelman–Pohley bioassay (BA), based on animal use, for the determination of human follicle-stimulating hormone (hFSH) biological activity. A linear relationship (BAIU=0.9925 RP-HPLCIU−1.3165) with a high...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2011-03, Vol.54 (4), p.681-686
Hauptverfasser:	Almeida, B.E., Oliveira, J.E., Damiani, R., Dalmora, S.L., Bartolini, P., Ribela, M.T.C.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Analytical, structural and metabolic biochemistry Animal Testing Alternatives Animals bioactive properties Bioassay bioassays Biological and medical sciences Biological Assay Chemistry, Pharmaceutical Chromatography, High Pressure Liquid confidence interval equations Female Follicle Stimulating Hormone, Human - analysis Follicle Stimulating Hormone, Human - pharmacology follicle-stimulating hormone Fundamental and applied biological sciences. Psychology General pharmacology hFSH Human follicle-stimulating hormone human serum albumin Humans Medical sciences Organ Size - drug effects Ovary - drug effects Ovary - growth & development Pharmacology. Drug treatments Pilot Projects Potency Quality Control Rats Rats, Sprague-Dawley Recombinant Proteins - analysis Recombinant Proteins - pharmacology Reproducibility of Results reversed-phase high performance liquid chromatography RP-HPLC Serum Albumin Technology, Pharmaceutical
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