novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage

Proper response to DNA damage is essential for maintaining the integrity of the genome. Here we show that in response to ultraviolet (UV) radiation, the Lats2 tumor suppressor protein is phosphorylated predominantly by Chk1 and weakly by Chk2 at S408 in vivo, and that this process occurs at all stag...

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Veröffentlicht in:	Journal of cell science 2011, Vol.124 (1), p.57-67
Hauptverfasser:	Okada, Nobuhiro, Yabuta, Norikazu, Suzuki, Hirokazu, Aylon, Yael, Oren, Moshe, Nojima, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Cell Line Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage - radiation effects Humans Organelles - enzymology Organelles - genetics Organelles - metabolism Organelles - radiation effects Phosphorylation - radiation effects Protein Kinases - genetics Protein Kinases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Radiation Signal Transduction - radiation effects Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ultraviolet Rays
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