Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes
Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated. To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria. We evaluated 28 patients with...
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| Veröffentlicht in: | Journal of endocrinological investigation 2010-11, Vol.33 (10), p.696-700 |
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| container_title | Journal of endocrinological investigation |
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| creator | Silva, A M V Schaan, B D Signori, L U Plentz, R D M Moreno, Jr, H Bertoluci, M C Irigoyen, M C |
| description | Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated.
To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria.
We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) |
| doi_str_mv | 10.3275/6955 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_820790822</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>820790822</sourcerecordid><originalsourceid>FETCH-LOGICAL-p125t-7416cc05cba1b1954668d7ba7e160c6e50688a0aaaf62e741d8ecbca0a1251ae3</originalsourceid><addsrcrecordid>eNo1kE1LAzEQhoMgtrb-BcnN02qS3Xz0KMUvqHip52U2mdLIbnbdZCu9-8MNtMLAzPvyzAszhCw5uy-Flg9qJeUFmXMtWGFKo2bkOsYvxkpdGn1FZoKVsso1J7_v3o49tM3U-TCNHqiPFGLsrYeEjv74tKe-G8CPWcGYMDMtheDoAUM_RYrB9WmPrZ-6wuGQJYZEDxB751tIvg_UBzrkKfvxFLg9DkgFdR4aTBiX5HIHbcSbc1-Qz-en7fq12Hy8vK0fN8XAhUyFrriylknbAG_4SlZKGacb0MgVswolU8YAA4CdEphpZ9A2Njt5nQOWC3J3yh3G_nvCmOrOR4ttCwHzKbURTK-YESKTt2dyajp09TD6DsZj_f-48g_3X28L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>820790822</pqid></control><display><type>article</type><title>Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Silva, A M V ; Schaan, B D ; Signori, L U ; Plentz, R D M ; Moreno, Jr, H ; Bertoluci, M C ; Irigoyen, M C</creator><creatorcontrib>Silva, A M V ; Schaan, B D ; Signori, L U ; Plentz, R D M ; Moreno, Jr, H ; Bertoluci, M C ; Irigoyen, M C</creatorcontrib><description>Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated.
To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria.
We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively.
Patients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA(₁c): 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA(₁c) (r=-0.41; p=0.032). The same was observed between flow mediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA(₁c) (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007).
Both venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis.</description><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.3275/6955</identifier><identifier>PMID: 20354354</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Aged ; Albuminuria - complications ; Albuminuria - epidemiology ; Albuminuria - physiopathology ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Angiopathies - complications ; Diabetic Angiopathies - diagnosis ; Diabetic Angiopathies - epidemiology ; Diabetic Angiopathies - physiopathology ; Diagnostic Techniques, Cardiovascular ; Endothelium, Vascular - physiopathology ; Female ; Hand - blood supply ; Humans ; Male ; Middle Aged ; Regional Blood Flow ; Ultrasonography ; Vasodilation - physiology ; Veins - physiopathology</subject><ispartof>Journal of endocrinological investigation, 2010-11, Vol.33 (10), p.696-700</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20354354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, A M V</creatorcontrib><creatorcontrib>Schaan, B D</creatorcontrib><creatorcontrib>Signori, L U</creatorcontrib><creatorcontrib>Plentz, R D M</creatorcontrib><creatorcontrib>Moreno, Jr, H</creatorcontrib><creatorcontrib>Bertoluci, M C</creatorcontrib><creatorcontrib>Irigoyen, M C</creatorcontrib><title>Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated.
To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria.
We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively.
Patients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA(₁c): 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA(₁c) (r=-0.41; p=0.032). The same was observed between flow mediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA(₁c) (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007).
Both venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis.</description><subject>Adult</subject><subject>Aged</subject><subject>Albuminuria - complications</subject><subject>Albuminuria - epidemiology</subject><subject>Albuminuria - physiopathology</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Angiopathies - complications</subject><subject>Diabetic Angiopathies - diagnosis</subject><subject>Diabetic Angiopathies - epidemiology</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Diagnostic Techniques, Cardiovascular</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Hand - blood supply</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Regional Blood Flow</subject><subject>Ultrasonography</subject><subject>Vasodilation - physiology</subject><subject>Veins - physiopathology</subject><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LAzEQhoMgtrb-BcnN02qS3Xz0KMUvqHip52U2mdLIbnbdZCu9-8MNtMLAzPvyzAszhCw5uy-Flg9qJeUFmXMtWGFKo2bkOsYvxkpdGn1FZoKVsso1J7_v3o49tM3U-TCNHqiPFGLsrYeEjv74tKe-G8CPWcGYMDMtheDoAUM_RYrB9WmPrZ-6wuGQJYZEDxB751tIvg_UBzrkKfvxFLg9DkgFdR4aTBiX5HIHbcSbc1-Qz-en7fq12Hy8vK0fN8XAhUyFrriylknbAG_4SlZKGacb0MgVswolU8YAA4CdEphpZ9A2Njt5nQOWC3J3yh3G_nvCmOrOR4ttCwHzKbURTK-YESKTt2dyajp09TD6DsZj_f-48g_3X28L</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Silva, A M V</creator><creator>Schaan, B D</creator><creator>Signori, L U</creator><creator>Plentz, R D M</creator><creator>Moreno, Jr, H</creator><creator>Bertoluci, M C</creator><creator>Irigoyen, M C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201011</creationdate><title>Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes</title><author>Silva, A M V ; Schaan, B D ; Signori, L U ; Plentz, R D M ; Moreno, Jr, H ; Bertoluci, M C ; Irigoyen, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-7416cc05cba1b1954668d7ba7e160c6e50688a0aaaf62e741d8ecbca0a1251ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Albuminuria - complications</topic><topic>Albuminuria - epidemiology</topic><topic>Albuminuria - physiopathology</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Angiopathies - complications</topic><topic>Diabetic Angiopathies - diagnosis</topic><topic>Diabetic Angiopathies - epidemiology</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Diagnostic Techniques, Cardiovascular</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Hand - blood supply</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Regional Blood Flow</topic><topic>Ultrasonography</topic><topic>Vasodilation - physiology</topic><topic>Veins - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, A M V</creatorcontrib><creatorcontrib>Schaan, B D</creatorcontrib><creatorcontrib>Signori, L U</creatorcontrib><creatorcontrib>Plentz, R D M</creatorcontrib><creatorcontrib>Moreno, Jr, H</creatorcontrib><creatorcontrib>Bertoluci, M C</creatorcontrib><creatorcontrib>Irigoyen, M C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, A M V</au><au>Schaan, B D</au><au>Signori, L U</au><au>Plentz, R D M</au><au>Moreno, Jr, H</au><au>Bertoluci, M C</au><au>Irigoyen, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>2010-11</date><risdate>2010</risdate><volume>33</volume><issue>10</issue><spage>696</spage><epage>700</epage><pages>696-700</pages><eissn>1720-8386</eissn><abstract>Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated.
To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria.
We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively.
Patients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA(₁c): 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA(₁c) (r=-0.41; p=0.032). The same was observed between flow mediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA(₁c) (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007).
Both venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis.</abstract><cop>Italy</cop><pmid>20354354</pmid><doi>10.3275/6955</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Albuminuria - complications Albuminuria - epidemiology Albuminuria - physiopathology Brachial Artery - diagnostic imaging Brachial Artery - physiopathology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - complications Diabetic Angiopathies - diagnosis Diabetic Angiopathies - epidemiology Diabetic Angiopathies - physiopathology Diagnostic Techniques, Cardiovascular Endothelium, Vascular - physiopathology Female Hand - blood supply Humans Male Middle Aged Regional Blood Flow Ultrasonography Vasodilation - physiology Veins - physiopathology |
| title | Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes |
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