Sequential Transplant of Paired Kidneys Following Donation After Cardiac Death: Impact of Longer Cold Ischemia Time on the Second Kidney on Graft and Patient Outcome
Abstract The United Kingdom has no national sharing scheme for kidneys received from donation after cardiac death (DCD). Therefore, both kidneys retrieved by a transplant team are implanted at a single unit, often sequentially. This study analyzes the impact of a prolonged cold ischaemia time on the...
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| Veröffentlicht in: | Transplantation proceedings 2010-12, Vol.42 (10), p.3960-3962 |
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| creator | Goldsmith, P.J Ridgway, D.M Pine, J.K Ecuyer, C Baker, R Newstead, C Hostert, L Pollard, S.G Attia, M Menon, K.V Ahmad, N |
| description | Abstract The United Kingdom has no national sharing scheme for kidneys received from donation after cardiac death (DCD). Therefore, both kidneys retrieved by a transplant team are implanted at a single unit, often sequentially. This study analyzes the impact of a prolonged cold ischaemia time on the second transplanted kidney and the effects on short-term and long-term outcomes in all our DCD renal implants from 2002 to 2009. Cold ischaemia time was significantly longer with the second kidney ( P = .04) as was delayed graft function ( P = .02). Acute rejection was increased in the first transplanted kidney ( P < .001). Five-year patient survival was comparable between groups, but 5-year graft survival was higher in the second transplanted group ( P = .04). The results confirm that, provided recipient centers are willing to accept higher initial rates of delayed graft function, it is acceptable to transplant DCD grafts sequentially without jeopardizing long-term graft or recipient outcome. |
| doi_str_mv | 10.1016/j.transproceed.2010.09.135 |
| format | Article |
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Therefore, both kidneys retrieved by a transplant team are implanted at a single unit, often sequentially. This study analyzes the impact of a prolonged cold ischaemia time on the second transplanted kidney and the effects on short-term and long-term outcomes in all our DCD renal implants from 2002 to 2009. Cold ischaemia time was significantly longer with the second kidney ( P = .04) as was delayed graft function ( P = .02). Acute rejection was increased in the first transplanted kidney ( P < .001). Five-year patient survival was comparable between groups, but 5-year graft survival was higher in the second transplanted group ( P = .04). The results confirm that, provided recipient centers are willing to accept higher initial rates of delayed graft function, it is acceptable to transplant DCD grafts sequentially without jeopardizing long-term graft or recipient outcome.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.09.135</identifier><identifier>PMID: 21168599</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Clinical death. Palliative care. Organ gift and preservation ; Death ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Survival ; Humans ; Ischemia ; Kidney - blood supply ; Kidney Transplantation ; Male ; Medical sciences ; Retrospective Studies ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue and Organ Procurement ; Tissue Donors ; Tissue, organ and graft immunology ; Treatment Outcome</subject><ispartof>Transplantation proceedings, 2010-12, Vol.42 (10), p.3960-3962</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-abde0f1a7d85ed8c66402e2688113327495fa49fac4c6049cc563422d5ee083c3</citedby><cites>FETCH-LOGICAL-c464t-abde0f1a7d85ed8c66402e2688113327495fa49fac4c6049cc563422d5ee083c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134510015575$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23841916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21168599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldsmith, P.J</creatorcontrib><creatorcontrib>Ridgway, D.M</creatorcontrib><creatorcontrib>Pine, J.K</creatorcontrib><creatorcontrib>Ecuyer, C</creatorcontrib><creatorcontrib>Baker, R</creatorcontrib><creatorcontrib>Newstead, C</creatorcontrib><creatorcontrib>Hostert, L</creatorcontrib><creatorcontrib>Pollard, S.G</creatorcontrib><creatorcontrib>Attia, M</creatorcontrib><creatorcontrib>Menon, K.V</creatorcontrib><creatorcontrib>Ahmad, N</creatorcontrib><title>Sequential Transplant of Paired Kidneys Following Donation After Cardiac Death: Impact of Longer Cold Ischemia Time on the Second Kidney on Graft and Patient Outcome</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract The United Kingdom has no national sharing scheme for kidneys received from donation after cardiac death (DCD). Therefore, both kidneys retrieved by a transplant team are implanted at a single unit, often sequentially. This study analyzes the impact of a prolonged cold ischaemia time on the second transplanted kidney and the effects on short-term and long-term outcomes in all our DCD renal implants from 2002 to 2009. Cold ischaemia time was significantly longer with the second kidney ( P = .04) as was delayed graft function ( P = .02). Acute rejection was increased in the first transplanted kidney ( P < .001). Five-year patient survival was comparable between groups, but 5-year graft survival was higher in the second transplanted group ( P = .04). The results confirm that, provided recipient centers are willing to accept higher initial rates of delayed graft function, it is acceptable to transplant DCD grafts sequentially without jeopardizing long-term graft or recipient outcome.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>Death</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Kidney - blood supply</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue and Organ Procurement</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUl1vEzEQPCEQTQt_AVlIiKcEf92drw9IVUJLRKRWSni2XHuvcbizU9sB5Qf1f-JrEoF44sny7uzMamaL4j3BE4JJ9WkzSUG5uA1eA5gJxbmBmwlh5YtiRETNxrSi7GUxwpiTMWG8PCvOY9zg_KecvS7OKCGVKJtmVDwt4XEHLlnVodUza6dcQr5Fd8oGMOibNQ72EV37rvO_rHtAM-9Ust6hqzZBQFMVjFUazUCl9SWa91ulnwkW3j0Mfd8ZNI96Db1VaGV7QHk2rQEtQXt3UhiKN0G1Calcu8sKeSt0u0va9_CmeNWqLsLb43tRfL_-spp-HS9ub-bTq8VY84qnsbo3gFuiaiNKMEJXFccUaCUEIYzRmjdlq3jTKs11hXmjdVkxTqkpAbBgml0UHw-82dtsS0yyt1FDlz0Bv4tSUFyLRvA6Iy8PSB18jAFauQ22V2EvCZZDSnIj_05JDilJ3MicUh5-d5TZ3fe5dxo9xZIBH44AFbXq2kykbfyDY4KThlQZNzvgIJvy00KQUWffNJicnU7SePt_-3z-h0Z31tms_AP2EDd-F1y2XRIZqcRyOdzVcFYEY1KWdcl-A6UvzY4</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Goldsmith, P.J</creator><creator>Ridgway, D.M</creator><creator>Pine, J.K</creator><creator>Ecuyer, C</creator><creator>Baker, R</creator><creator>Newstead, C</creator><creator>Hostert, L</creator><creator>Pollard, S.G</creator><creator>Attia, M</creator><creator>Menon, K.V</creator><creator>Ahmad, N</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Sequential Transplant of Paired Kidneys Following Donation After Cardiac Death: Impact of Longer Cold Ischemia Time on the Second Kidney on Graft and Patient Outcome</title><author>Goldsmith, P.J ; Ridgway, D.M ; Pine, J.K ; Ecuyer, C ; Baker, R ; Newstead, C ; Hostert, L ; Pollard, S.G ; Attia, M ; Menon, K.V ; Ahmad, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-abde0f1a7d85ed8c66402e2688113327495fa49fac4c6049cc563422d5ee083c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Clinical death. Palliative care. Organ gift and preservation</topic><topic>Death</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Kidney - blood supply</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Clinical death. Palliative care. Organ gift and preservation Death Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival Humans Ischemia Kidney - blood supply Kidney Transplantation Male Medical sciences Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue and Organ Procurement Tissue Donors Tissue, organ and graft immunology Treatment Outcome |
| title | Sequential Transplant of Paired Kidneys Following Donation After Cardiac Death: Impact of Longer Cold Ischemia Time on the Second Kidney on Graft and Patient Outcome |
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