Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus
Tissue-type plasminogen activator (tPA) plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behaviours. Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotox...
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| Veröffentlicht in: | Neurochemistry international 2011, Vol.58 (1), p.1-4 |
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| creator | Horii-Hayashi, Noriko Yoshikawa, Masahide Matsusue, Yumiko Ishizaka, Shigeaki Nishi, Mayumi Wanaka, Akio |
| description | Tissue-type plasminogen activator (tPA) plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behaviours. Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotoxic injury, and stress change tPA activity in the brain, no studies have ever examined whether environmental stimulation affect tPA activity in the brain. The aim of this study is to clarify the effect of environmental enrichment on tPA activity in the hippocampus and cerebral cortex of adult mouse brain. Zymographic analysis revealed that hippocampal tPA activity was higher in enriched mice than in standard-caged mice, whereas no significant changes in the cerebral cortex were detected between enriched and control mice. Enrichment-enhanced tPA activity reverted to the pre-enrichment level after mice were returned to a standard housing condition, suggesting that tPA upregulation is stimulation-dependent and reversible. These results suggest that tPA activity is regulated reversibly in an experience-dependent manner in the adult hippocampus. |
| doi_str_mv | 10.1016/j.neuint.2010.10.007 |
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Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotoxic injury, and stress change tPA activity in the brain, no studies have ever examined whether environmental stimulation affect tPA activity in the brain. The aim of this study is to clarify the effect of environmental enrichment on tPA activity in the hippocampus and cerebral cortex of adult mouse brain. Zymographic analysis revealed that hippocampal tPA activity was higher in enriched mice than in standard-caged mice, whereas no significant changes in the cerebral cortex were detected between enriched and control mice. Enrichment-enhanced tPA activity reverted to the pre-enrichment level after mice were returned to a standard housing condition, suggesting that tPA upregulation is stimulation-dependent and reversible. 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Psychology ; Hippocampus ; Hippocampus - metabolism ; Hippocampus - physiology ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Mossy Fibers, Hippocampal - metabolism ; Neuronal Plasticity - physiology ; Plasticity ; Protease ; Tissue Plasminogen Activator - metabolism ; Tissue-type plasminogen activator ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurochemistry international, 2011, Vol.58 (1), p.1-4</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-754f021049d467f816dd00d8a5bb59e3e43655a26ace74e283a479ad0de6ddf3</citedby><cites>FETCH-LOGICAL-c457t-754f021049d467f816dd00d8a5bb59e3e43655a26ace74e283a479ad0de6ddf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197018610003207$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23739963$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20974200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horii-Hayashi, Noriko</creatorcontrib><creatorcontrib>Yoshikawa, Masahide</creatorcontrib><creatorcontrib>Matsusue, Yumiko</creatorcontrib><creatorcontrib>Ishizaka, Shigeaki</creatorcontrib><creatorcontrib>Nishi, Mayumi</creatorcontrib><creatorcontrib>Wanaka, Akio</creatorcontrib><title>Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>Tissue-type plasminogen activator (tPA) plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behaviours. Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotoxic injury, and stress change tPA activity in the brain, no studies have ever examined whether environmental stimulation affect tPA activity in the brain. The aim of this study is to clarify the effect of environmental enrichment on tPA activity in the hippocampus and cerebral cortex of adult mouse brain. Zymographic analysis revealed that hippocampal tPA activity was higher in enriched mice than in standard-caged mice, whereas no significant changes in the cerebral cortex were detected between enriched and control mice. Enrichment-enhanced tPA activity reverted to the pre-enrichment level after mice were returned to a standard housing condition, suggesting that tPA upregulation is stimulation-dependent and reversible. These results suggest that tPA activity is regulated reversibly in an experience-dependent manner in the adult hippocampus.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - physiology</subject><subject>Environment</subject><subject>Environmental enrichment</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mossy Fibers, Hippocampal - metabolism</subject><subject>Neuronal Plasticity - physiology</subject><subject>Plasticity</subject><subject>Protease</subject><subject>Tissue Plasminogen Activator - metabolism</subject><subject>Tissue-type plasminogen activator</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EotvCGyDkC-KUZZI4cXxBQlWhSJW49G7N2pOul8QJtrPSvn29ZIEbpxmNvpn59TH2roRtCWX76bD1tDifthX8Hm0B5Au2KTtZFUo24iXbQKlkAWXXXrHrGA-QCQXNa3ZVgZKiAtiwn3f-6MLkR_IJBx6TG5cBk5s8N3v0TxR5cjEuVKTTTHweMI7OT0_kOZrkjpimsHYunbjzPO2Jo12GxMdpicT3bp4ng-O8xDfsVY9DpLeXesMev9493t4XDz--fb_98lAY0chU5Ow9VCUIZUUr-65srQWwHTa7XaOoJlG3TYNVi4akoKqrUUiFFixlsq9v2Mf17BymXwvFpEcXDQ0DesqRdFeB7JSomkyKlTRhijFQr-fgRgwnXYI-S9YHvUrWZ8nnaVaY195fHiy7kezfpT9WM_DhAmA0OPQBvXHxH1fLWqm2ztznlaNs4-go6GgceUPWBTJJ28n9P8kz4JWfkQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Horii-Hayashi, Noriko</creator><creator>Yoshikawa, Masahide</creator><creator>Matsusue, Yumiko</creator><creator>Ishizaka, Shigeaki</creator><creator>Nishi, Mayumi</creator><creator>Wanaka, Akio</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus</title><author>Horii-Hayashi, Noriko ; Yoshikawa, Masahide ; Matsusue, Yumiko ; Ishizaka, Shigeaki ; Nishi, Mayumi ; Wanaka, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-754f021049d467f816dd00d8a5bb59e3e43655a26ace74e283a479ad0de6ddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - physiology</topic><topic>Environment</topic><topic>Environmental enrichment</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mossy Fibers, Hippocampal - metabolism</topic><topic>Neuronal Plasticity - physiology</topic><topic>Plasticity</topic><topic>Protease</topic><topic>Tissue Plasminogen Activator - metabolism</topic><topic>Tissue-type plasminogen activator</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horii-Hayashi, Noriko</creatorcontrib><creatorcontrib>Yoshikawa, Masahide</creatorcontrib><creatorcontrib>Matsusue, Yumiko</creatorcontrib><creatorcontrib>Ishizaka, Shigeaki</creatorcontrib><creatorcontrib>Nishi, Mayumi</creatorcontrib><creatorcontrib>Wanaka, Akio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horii-Hayashi, Noriko</au><au>Yoshikawa, Masahide</au><au>Matsusue, Yumiko</au><au>Ishizaka, Shigeaki</au><au>Nishi, Mayumi</au><au>Wanaka, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2011</date><risdate>2011</risdate><volume>58</volume><issue>1</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><coden>NEUIDS</coden><abstract>Tissue-type plasminogen activator (tPA) plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behaviours. Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotoxic injury, and stress change tPA activity in the brain, no studies have ever examined whether environmental stimulation affect tPA activity in the brain. The aim of this study is to clarify the effect of environmental enrichment on tPA activity in the hippocampus and cerebral cortex of adult mouse brain. Zymographic analysis revealed that hippocampal tPA activity was higher in enriched mice than in standard-caged mice, whereas no significant changes in the cerebral cortex were detected between enriched and control mice. Enrichment-enhanced tPA activity reverted to the pre-enrichment level after mice were returned to a standard housing condition, suggesting that tPA upregulation is stimulation-dependent and reversible. 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| subjects | Animals Biological and medical sciences Cerebral Cortex - metabolism Cerebral Cortex - physiology Environment Environmental enrichment Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - metabolism Hippocampus - physiology Immunohistochemistry Male Mice Mice, Inbred C57BL Mossy Fibers, Hippocampal - metabolism Neuronal Plasticity - physiology Plasticity Protease Tissue Plasminogen Activator - metabolism Tissue-type plasminogen activator Vertebrates: nervous system and sense organs |
| title | Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus |
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