Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro
Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovar...
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| Veröffentlicht in: | Fertility and sterility 2011, Vol.95 (1), p.461-463 |
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| container_title | Fertility and sterility |
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| creator | Zhao, Lu, M.D Li, Wei, M.Sc Han, Fengjuan, M.D., Ph.D Hou, Lihui, M.D Baillargeon, Jean-Patrice, M.D., Ph.D Kuang, Haixue, Ph.D Wang, Yongyan, M.D Wu, Xiaoke, M.D., Ph.D |
| description | Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome. |
| doi_str_mv | 10.1016/j.fertnstert.2010.07.1090 |
| format | Article |
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Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2010.07.1090</identifier><identifier>PMID: 20840879</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>animal ovaries ; berberine ; Berberine - pharmacology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cells, Cultured ; dexamethasone ; Dexamethasone - pharmacology ; Drug Interactions ; Female ; Female genital diseases ; Glucocorticoids - pharmacology ; glucose ; Glucose - pharmacokinetics ; Gynecology. Andrology. Obstetrics ; Humans ; hyperandrogenism ; Hyperandrogenism - metabolism ; In Vitro Techniques ; induced resistance ; Insulin Resistance ; Internal Medicine ; Medical sciences ; Non tumoral diseases ; Obstetrics and Gynecology ; ovarian theca cells ; pathogenesis ; Pharmacology. Drug treatments ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - metabolism ; testosterone ; Theca Cells - cytology ; Theca Cells - drug effects ; Theca Cells - metabolism</subject><ispartof>Fertility and sterility, 2011, Vol.95 (1), p.461-463</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2011 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-9043e5720a1e08557268148a604a9450299183745da518557d35fdb8c998a1af3</citedby><cites>FETCH-LOGICAL-c536t-9043e5720a1e08557268148a604a9450299183745da518557d35fdb8c998a1af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028210022168$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23961248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20840879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Lu, M.D</creatorcontrib><creatorcontrib>Li, Wei, M.Sc</creatorcontrib><creatorcontrib>Han, Fengjuan, M.D., Ph.D</creatorcontrib><creatorcontrib>Hou, Lihui, M.D</creatorcontrib><creatorcontrib>Baillargeon, Jean-Patrice, M.D., Ph.D</creatorcontrib><creatorcontrib>Kuang, Haixue, Ph.D</creatorcontrib><creatorcontrib>Wang, Yongyan, M.D</creatorcontrib><creatorcontrib>Wu, Xiaoke, M.D., Ph.D</creatorcontrib><title>Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.</description><subject>animal ovaries</subject><subject>berberine</subject><subject>Berberine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cells, Cultured</subject><subject>dexamethasone</subject><subject>Dexamethasone - pharmacology</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Glucocorticoids - pharmacology</subject><subject>glucose</subject><subject>Glucose - pharmacokinetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>hyperandrogenism</subject><subject>Hyperandrogenism - metabolism</subject><subject>In Vitro Techniques</subject><subject>induced resistance</subject><subject>Insulin Resistance</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Obstetrics and Gynecology</subject><subject>ovarian theca cells</subject><subject>pathogenesis</subject><subject>Pharmacology. Drug treatments</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>testosterone</subject><subject>Theca Cells - cytology</subject><subject>Theca Cells - drug effects</subject><subject>Theca Cells - metabolism</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAQxy0EYsvCV4BwQJxSxk6c2BckqHhJK3FYerZcZ8K6pMniSVb02zNWCytx4uLHzG8e_o-FeClhLUE2b_brHtM80szrWgGboWWPhQdiJbVuSt3o6qFYAUhdgjLqQjwh2gNAI1v1WFwoMDWY1q7E9j2mHaY4YpGwWwJSEUdahjjynSLNfgzIpuzqit2x6PCXP-B842kas6OYbzD4IuAw5NDiLs5peioe9X4gfHbeL8X244dvm8_l1ddPXzbvrsqgq2YuLdQV6laBlwhG86kxsja-gdrbWoOyVpqqrXXntcz-rtJ9tzPBWuOl76tL8fqU9zZNPxek2R0i5Vb8iNNCzihoDb_TMmlPZEgTUcLe3aZ48OnoJLgsqtu7e1FdFtVB67KoHPv8XGXZHbD7G_lHRQZenQFPwQ99YtEi3XOVbaSqDXMvTlzvJ-e_J2a211xK86BUq2QmNicCWbW7iMlRiMgj6GLCMLtuiv_V8Nt_sgQeaOTWfuARaT8taeSxOOlIOXDX-Z_kbyIBlJKNqX4DDyq4DQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Zhao, Lu, M.D</creator><creator>Li, Wei, M.Sc</creator><creator>Han, Fengjuan, M.D., Ph.D</creator><creator>Hou, Lihui, M.D</creator><creator>Baillargeon, Jean-Patrice, M.D., Ph.D</creator><creator>Kuang, Haixue, Ph.D</creator><creator>Wang, Yongyan, M.D</creator><creator>Wu, Xiaoke, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro</title><author>Zhao, Lu, M.D ; Li, Wei, M.Sc ; Han, Fengjuan, M.D., Ph.D ; Hou, Lihui, M.D ; Baillargeon, Jean-Patrice, M.D., Ph.D ; Kuang, Haixue, Ph.D ; Wang, Yongyan, M.D ; Wu, Xiaoke, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-9043e5720a1e08557268148a604a9450299183745da518557d35fdb8c998a1af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>animal ovaries</topic><topic>berberine</topic><topic>Berberine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cells, Cultured</topic><topic>dexamethasone</topic><topic>Dexamethasone - pharmacology</topic><topic>Drug Interactions</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Glucocorticoids - pharmacology</topic><topic>glucose</topic><topic>Glucose - pharmacokinetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>hyperandrogenism</topic><topic>Hyperandrogenism - metabolism</topic><topic>In Vitro Techniques</topic><topic>induced resistance</topic><topic>Insulin Resistance</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Obstetrics and Gynecology</topic><topic>ovarian theca cells</topic><topic>pathogenesis</topic><topic>Pharmacology. Drug treatments</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>testosterone</topic><topic>Theca Cells - cytology</topic><topic>Theca Cells - drug effects</topic><topic>Theca Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Lu, M.D</creatorcontrib><creatorcontrib>Li, Wei, M.Sc</creatorcontrib><creatorcontrib>Han, Fengjuan, M.D., Ph.D</creatorcontrib><creatorcontrib>Hou, Lihui, M.D</creatorcontrib><creatorcontrib>Baillargeon, Jean-Patrice, M.D., Ph.D</creatorcontrib><creatorcontrib>Kuang, Haixue, Ph.D</creatorcontrib><creatorcontrib>Wang, Yongyan, M.D</creatorcontrib><creatorcontrib>Wu, Xiaoke, M.D., Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Lu, M.D</au><au>Li, Wei, M.Sc</au><au>Han, Fengjuan, M.D., Ph.D</au><au>Hou, Lihui, M.D</au><au>Baillargeon, Jean-Patrice, M.D., Ph.D</au><au>Kuang, Haixue, Ph.D</au><au>Wang, Yongyan, M.D</au><au>Wu, Xiaoke, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2011</date><risdate>2011</risdate><volume>95</volume><issue>1</issue><spage>461</spage><epage>463</epage><pages>461-463</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | animal ovaries berberine Berberine - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cells, Cultured dexamethasone Dexamethasone - pharmacology Drug Interactions Female Female genital diseases Glucocorticoids - pharmacology glucose Glucose - pharmacokinetics Gynecology. Andrology. Obstetrics Humans hyperandrogenism Hyperandrogenism - metabolism In Vitro Techniques induced resistance Insulin Resistance Internal Medicine Medical sciences Non tumoral diseases Obstetrics and Gynecology ovarian theca cells pathogenesis Pharmacology. Drug treatments Polycystic ovary syndrome Polycystic Ovary Syndrome - metabolism testosterone Theca Cells - cytology Theca Cells - drug effects Theca Cells - metabolism |
| title | Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro |
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