Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro

Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovar...

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Veröffentlicht in:	Fertility and sterility 2011, Vol.95 (1), p.461-463
Hauptverfasser:	Zhao, Lu, M.D, Li, Wei, M.Sc, Han, Fengjuan, M.D., Ph.D, Hou, Lihui, M.D, Baillargeon, Jean-Patrice, M.D., Ph.D, Kuang, Haixue, Ph.D, Wang, Yongyan, M.D, Wu, Xiaoke, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	animal ovaries berberine Berberine - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cells, Cultured dexamethasone Dexamethasone - pharmacology Drug Interactions Female Female genital diseases Glucocorticoids - pharmacology glucose Glucose - pharmacokinetics Gynecology. Andrology. Obstetrics Humans hyperandrogenism Hyperandrogenism - metabolism In Vitro Techniques induced resistance Insulin Resistance Internal Medicine Medical sciences Non tumoral diseases Obstetrics and Gynecology ovarian theca cells pathogenesis Pharmacology. Drug treatments Polycystic ovary syndrome Polycystic Ovary Syndrome - metabolism testosterone Theca Cells - cytology Theca Cells - drug effects Theca Cells - metabolism
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Zusammenfassung:	Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2010.07.1090