Continued depression of maximal oxygen consumption and mitochondrial proteomic expression despite successful coronary artery bypass grafting in a swine model of hibernation
Objective Clinical studies indicate incomplete functional recovery of hibernating myocardium after coronary artery bypass grafting. We hypothesized that persistent contractile abnormalities after coronary artery bypass grafting are associated with decreased mitochondrial proteins involving electron...
Gespeichert in:
| Veröffentlicht in: | The Journal of thoracic and cardiovascular surgery 2011, Vol.141 (1), p.261-268 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | 1 |
| container_start_page | 261 |
| container_title | The Journal of thoracic and cardiovascular surgery |
| container_volume | 141 |
| creator | Kelly, Rosemary F., MD Cabrera, Jesús A., MD, PhD Ziemba, Elizabeth A., MD Crampton, Melanie Anderson, Lorraine B., PhD McFalls, Edward O., MD Ward, Herbert B., MD, PhD |
| description | Objective Clinical studies indicate incomplete functional recovery of hibernating myocardium after coronary artery bypass grafting. We hypothesized that persistent contractile abnormalities after coronary artery bypass grafting are associated with decreased mitochondrial proteins involving electron transport chain that might limit maximal oxygen consumption. Methods Seven pigs with hibernating myocardium underwent off-pump revascularization with left internal thoracic artery to mid left anterior descending artery. At 4 weeks, left internal thoracic artery anastomosis was patent by multidetector computed tomography. Regional function (transthoracic echocardiography) and blood flow (microspheres) were assessed at rest and during high-dose dobutamine (40 μg/[kg · min]). Expression of electron transport chain proteins was analyzed with isobaric tags for relative and absolute quantification. Results After revascularization, multidetector computed tomography confirmed severe left anterior descending stenosis and patent left internal thoracic artery graft. Regional function and blood flow normalized at rest; however, function in left anterior descending distribution remained depressed relative to remote regions, and myocardial blood flow in that region did not increase normally when challenged with high-work state. Concomitant with reduced maximal blood flow response in left anterior descending region was more than 40% reduction in electron transport chain proteins essential to adenosine triphosphate production. Conclusions Despite successful revascularization of hibernating myocardium, regional function and blood flow remained depressed during catecholamine stress. Electron transport chain proteins known to be downregulated during adaptive process within hibernating myocardium did not normalize after revascularization. These data demonstrate a potential bioenergetic cause of persistent dysfunction and heart failure within successfully revascularized hibernating myocardium. |
| doi_str_mv | 10.1016/j.jtcvs.2010.08.061 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_820787856</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022522310010688</els_id><sourcerecordid>820787856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-bb9de22a63d797a5ba0626f6887ea3bb15a8c40f09b95ad5aa3851e493766ec53</originalsourceid><addsrcrecordid>eNqFUsuO1DAQjBCIHRa-AAn5gjhl8GPiOAeQViNe0kocAImb5didWQ-JHdzJMvNPfCQOMywSF04ttaury1VdFE8ZXTPK5Mv9ej_ZW1xzmjtUralk94oVo01dSlV9vV-sKOW8rDgXF8UjxD2ltKaseVhccMakooKuip_bGCYfZnDEwZgA0cdAYkcGc_CD6Uk8HHcQiI0B52GcllcTHBn8FO1NDC75DBpTnCAO3hI43JE4wNFPQHC2Nre6uc8sKQaTjsSkCXJpj6NBJLtkuixiR3wmJ_jDByBDdNAvQm58CymYZfPj4kFneoQn53pZfHn75vP2fXn98d2H7dV1aatqM5Vt2zjg3Ejh6qY2VWuo5LKTStVgRNuyyii7oR1t2qYyrjJGqIrBphG1lGArcVm8OPHmf32fASc9eLTQ9yZAnFErTmtVq0pmpDghbYqICTo9pmxbOmpG9ZKS3uvfKeklJU2VzinlqWdn_rkdwN3N_IklA56fAQat6btkgvX4FycaoepmEfrqhIPsxq2HpNF6CBacT2An7aL_j5DX_8zb3gefV36DI-A-ztn5HjXTyDXVn5aDWu6J0UyS_RS_AKxjzEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>820787856</pqid></control><display><type>article</type><title>Continued depression of maximal oxygen consumption and mitochondrial proteomic expression despite successful coronary artery bypass grafting in a swine model of hibernation</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kelly, Rosemary F., MD ; Cabrera, Jesús A., MD, PhD ; Ziemba, Elizabeth A., MD ; Crampton, Melanie ; Anderson, Lorraine B., PhD ; McFalls, Edward O., MD ; Ward, Herbert B., MD, PhD</creator><creatorcontrib>Kelly, Rosemary F., MD ; Cabrera, Jesús A., MD, PhD ; Ziemba, Elizabeth A., MD ; Crampton, Melanie ; Anderson, Lorraine B., PhD ; McFalls, Edward O., MD ; Ward, Herbert B., MD, PhD</creatorcontrib><description>Objective Clinical studies indicate incomplete functional recovery of hibernating myocardium after coronary artery bypass grafting. We hypothesized that persistent contractile abnormalities after coronary artery bypass grafting are associated with decreased mitochondrial proteins involving electron transport chain that might limit maximal oxygen consumption. Methods Seven pigs with hibernating myocardium underwent off-pump revascularization with left internal thoracic artery to mid left anterior descending artery. At 4 weeks, left internal thoracic artery anastomosis was patent by multidetector computed tomography. Regional function (transthoracic echocardiography) and blood flow (microspheres) were assessed at rest and during high-dose dobutamine (40 μg/[kg · min]). Expression of electron transport chain proteins was analyzed with isobaric tags for relative and absolute quantification. Results After revascularization, multidetector computed tomography confirmed severe left anterior descending stenosis and patent left internal thoracic artery graft. Regional function and blood flow normalized at rest; however, function in left anterior descending distribution remained depressed relative to remote regions, and myocardial blood flow in that region did not increase normally when challenged with high-work state. Concomitant with reduced maximal blood flow response in left anterior descending region was more than 40% reduction in electron transport chain proteins essential to adenosine triphosphate production. Conclusions Despite successful revascularization of hibernating myocardium, regional function and blood flow remained depressed during catecholamine stress. Electron transport chain proteins known to be downregulated during adaptive process within hibernating myocardium did not normalize after revascularization. These data demonstrate a potential bioenergetic cause of persistent dysfunction and heart failure within successfully revascularized hibernating myocardium.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/j.jtcvs.2010.08.061</identifier><identifier>PMID: 21168030</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adrenergic beta-1 Receptor Agonists - administration & dosage ; Adult and adolescent clinical studies ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Blood Flow Velocity ; Cardiology. Vascular system ; Cardiothoracic Surgery ; Coronary Angiography - methods ; Coronary Artery Bypass ; Coronary Circulation ; Coronary heart disease ; Depression ; Disease Models, Animal ; Dobutamine - administration & dosage ; Down-Regulation ; Electron Transport Chain Complex Proteins - metabolism ; Heart ; Medical sciences ; Mitochondria, Heart - metabolism ; Mitochondrial Proteins - metabolism ; Mood disorders ; Myocardial Stunning - diagnosis ; Myocardial Stunning - metabolism ; Myocardial Stunning - physiopathology ; Myocardial Stunning - surgery ; Myocardium - metabolism ; Myocardium - pathology ; Oxygen Consumption ; Pneumology ; Proteomics - methods ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Swine ; Tomography, X-Ray Computed ; Vascular Patency ; Ventricular Function, Left</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 2011, Vol.141 (1), p.261-268</ispartof><rights>The American Association for Thoracic Surgery</rights><rights>2011 The American Association for Thoracic Surgery</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 The American Association for Thoracic Surgery. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-bb9de22a63d797a5ba0626f6887ea3bb15a8c40f09b95ad5aa3851e493766ec53</citedby><cites>FETCH-LOGICAL-c554t-bb9de22a63d797a5ba0626f6887ea3bb15a8c40f09b95ad5aa3851e493766ec53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jtcvs.2010.08.061$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23938795$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21168030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, Rosemary F., MD</creatorcontrib><creatorcontrib>Cabrera, Jesús A., MD, PhD</creatorcontrib><creatorcontrib>Ziemba, Elizabeth A., MD</creatorcontrib><creatorcontrib>Crampton, Melanie</creatorcontrib><creatorcontrib>Anderson, Lorraine B., PhD</creatorcontrib><creatorcontrib>McFalls, Edward O., MD</creatorcontrib><creatorcontrib>Ward, Herbert B., MD, PhD</creatorcontrib><title>Continued depression of maximal oxygen consumption and mitochondrial proteomic expression despite successful coronary artery bypass grafting in a swine model of hibernation</title><title>The Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description>Objective Clinical studies indicate incomplete functional recovery of hibernating myocardium after coronary artery bypass grafting. We hypothesized that persistent contractile abnormalities after coronary artery bypass grafting are associated with decreased mitochondrial proteins involving electron transport chain that might limit maximal oxygen consumption. Methods Seven pigs with hibernating myocardium underwent off-pump revascularization with left internal thoracic artery to mid left anterior descending artery. At 4 weeks, left internal thoracic artery anastomosis was patent by multidetector computed tomography. Regional function (transthoracic echocardiography) and blood flow (microspheres) were assessed at rest and during high-dose dobutamine (40 μg/[kg · min]). Expression of electron transport chain proteins was analyzed with isobaric tags for relative and absolute quantification. Results After revascularization, multidetector computed tomography confirmed severe left anterior descending stenosis and patent left internal thoracic artery graft. Regional function and blood flow normalized at rest; however, function in left anterior descending distribution remained depressed relative to remote regions, and myocardial blood flow in that region did not increase normally when challenged with high-work state. Concomitant with reduced maximal blood flow response in left anterior descending region was more than 40% reduction in electron transport chain proteins essential to adenosine triphosphate production. Conclusions Despite successful revascularization of hibernating myocardium, regional function and blood flow remained depressed during catecholamine stress. Electron transport chain proteins known to be downregulated during adaptive process within hibernating myocardium did not normalize after revascularization. These data demonstrate a potential bioenergetic cause of persistent dysfunction and heart failure within successfully revascularized hibernating myocardium.</description><subject>Adrenergic beta-1 Receptor Agonists - administration & dosage</subject><subject>Adult and adolescent clinical studies</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Cardiology. Vascular system</subject><subject>Cardiothoracic Surgery</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Bypass</subject><subject>Coronary Circulation</subject><subject>Coronary heart disease</subject><subject>Depression</subject><subject>Disease Models, Animal</subject><subject>Dobutamine - administration & dosage</subject><subject>Down-Regulation</subject><subject>Electron Transport Chain Complex Proteins - metabolism</subject><subject>Heart</subject><subject>Medical sciences</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Mood disorders</subject><subject>Myocardial Stunning - diagnosis</subject><subject>Myocardial Stunning - metabolism</subject><subject>Myocardial Stunning - physiopathology</subject><subject>Myocardial Stunning - surgery</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Oxygen Consumption</subject><subject>Pneumology</subject><subject>Proteomics - methods</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Swine</subject><subject>Tomography, X-Ray Computed</subject><subject>Vascular Patency</subject><subject>Ventricular Function, Left</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQjBCIHRa-AAn5gjhl8GPiOAeQViNe0kocAImb5didWQ-JHdzJMvNPfCQOMywSF04ttaury1VdFE8ZXTPK5Mv9ej_ZW1xzmjtUralk94oVo01dSlV9vV-sKOW8rDgXF8UjxD2ltKaseVhccMakooKuip_bGCYfZnDEwZgA0cdAYkcGc_CD6Uk8HHcQiI0B52GcllcTHBn8FO1NDC75DBpTnCAO3hI43JE4wNFPQHC2Nre6uc8sKQaTjsSkCXJpj6NBJLtkuixiR3wmJ_jDByBDdNAvQm58CymYZfPj4kFneoQn53pZfHn75vP2fXn98d2H7dV1aatqM5Vt2zjg3Ejh6qY2VWuo5LKTStVgRNuyyii7oR1t2qYyrjJGqIrBphG1lGArcVm8OPHmf32fASc9eLTQ9yZAnFErTmtVq0pmpDghbYqICTo9pmxbOmpG9ZKS3uvfKeklJU2VzinlqWdn_rkdwN3N_IklA56fAQat6btkgvX4FycaoepmEfrqhIPsxq2HpNF6CBacT2An7aL_j5DX_8zb3gefV36DI-A-ztn5HjXTyDXVn5aDWu6J0UyS_RS_AKxjzEw</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Kelly, Rosemary F., MD</creator><creator>Cabrera, Jesús A., MD, PhD</creator><creator>Ziemba, Elizabeth A., MD</creator><creator>Crampton, Melanie</creator><creator>Anderson, Lorraine B., PhD</creator><creator>McFalls, Edward O., MD</creator><creator>Ward, Herbert B., MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Continued depression of maximal oxygen consumption and mitochondrial proteomic expression despite successful coronary artery bypass grafting in a swine model of hibernation</title><author>Kelly, Rosemary F., MD ; Cabrera, Jesús A., MD, PhD ; Ziemba, Elizabeth A., MD ; Crampton, Melanie ; Anderson, Lorraine B., PhD ; McFalls, Edward O., MD ; Ward, Herbert B., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-bb9de22a63d797a5ba0626f6887ea3bb15a8c40f09b95ad5aa3851e493766ec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adrenergic beta-1 Receptor Agonists - administration & dosage</topic><topic>Adult and adolescent clinical studies</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Cardiology. Vascular system</topic><topic>Cardiothoracic Surgery</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Bypass</topic><topic>Coronary Circulation</topic><topic>Coronary heart disease</topic><topic>Depression</topic><topic>Disease Models, Animal</topic><topic>Dobutamine - administration & dosage</topic><topic>Down-Regulation</topic><topic>Electron Transport Chain Complex Proteins - metabolism</topic><topic>Heart</topic><topic>Medical sciences</topic><topic>Mitochondria, Heart - metabolism</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Mood disorders</topic><topic>Myocardial Stunning - diagnosis</topic><topic>Myocardial Stunning - metabolism</topic><topic>Myocardial Stunning - physiopathology</topic><topic>Myocardial Stunning - surgery</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Oxygen Consumption</topic><topic>Pneumology</topic><topic>Proteomics - methods</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Swine</topic><topic>Tomography, X-Ray Computed</topic><topic>Vascular Patency</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, Rosemary F., MD</creatorcontrib><creatorcontrib>Cabrera, Jesús A., MD, PhD</creatorcontrib><creatorcontrib>Ziemba, Elizabeth A., MD</creatorcontrib><creatorcontrib>Crampton, Melanie</creatorcontrib><creatorcontrib>Anderson, Lorraine B., PhD</creatorcontrib><creatorcontrib>McFalls, Edward O., MD</creatorcontrib><creatorcontrib>Ward, Herbert B., MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelly, Rosemary F., MD</au><au>Cabrera, Jesús A., MD, PhD</au><au>Ziemba, Elizabeth A., MD</au><au>Crampton, Melanie</au><au>Anderson, Lorraine B., PhD</au><au>McFalls, Edward O., MD</au><au>Ward, Herbert B., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Continued depression of maximal oxygen consumption and mitochondrial proteomic expression despite successful coronary artery bypass grafting in a swine model of hibernation</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>2011</date><risdate>2011</risdate><volume>141</volume><issue>1</issue><spage>261</spage><epage>268</epage><pages>261-268</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><abstract>Objective Clinical studies indicate incomplete functional recovery of hibernating myocardium after coronary artery bypass grafting. We hypothesized that persistent contractile abnormalities after coronary artery bypass grafting are associated with decreased mitochondrial proteins involving electron transport chain that might limit maximal oxygen consumption. Methods Seven pigs with hibernating myocardium underwent off-pump revascularization with left internal thoracic artery to mid left anterior descending artery. At 4 weeks, left internal thoracic artery anastomosis was patent by multidetector computed tomography. Regional function (transthoracic echocardiography) and blood flow (microspheres) were assessed at rest and during high-dose dobutamine (40 μg/[kg · min]). Expression of electron transport chain proteins was analyzed with isobaric tags for relative and absolute quantification. Results After revascularization, multidetector computed tomography confirmed severe left anterior descending stenosis and patent left internal thoracic artery graft. Regional function and blood flow normalized at rest; however, function in left anterior descending distribution remained depressed relative to remote regions, and myocardial blood flow in that region did not increase normally when challenged with high-work state. Concomitant with reduced maximal blood flow response in left anterior descending region was more than 40% reduction in electron transport chain proteins essential to adenosine triphosphate production. Conclusions Despite successful revascularization of hibernating myocardium, regional function and blood flow remained depressed during catecholamine stress. Electron transport chain proteins known to be downregulated during adaptive process within hibernating myocardium did not normalize after revascularization. These data demonstrate a potential bioenergetic cause of persistent dysfunction and heart failure within successfully revascularized hibernating myocardium.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21168030</pmid><doi>10.1016/j.jtcvs.2010.08.061</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5223 |
| ispartof | The Journal of thoracic and cardiovascular surgery, 2011, Vol.141 (1), p.261-268 |
| issn | 0022-5223 1097-685X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_820787856 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenergic beta-1 Receptor Agonists - administration & dosage Adult and adolescent clinical studies Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Flow Velocity Cardiology. Vascular system Cardiothoracic Surgery Coronary Angiography - methods Coronary Artery Bypass Coronary Circulation Coronary heart disease Depression Disease Models, Animal Dobutamine - administration & dosage Down-Regulation Electron Transport Chain Complex Proteins - metabolism Heart Medical sciences Mitochondria, Heart - metabolism Mitochondrial Proteins - metabolism Mood disorders Myocardial Stunning - diagnosis Myocardial Stunning - metabolism Myocardial Stunning - physiopathology Myocardial Stunning - surgery Myocardium - metabolism Myocardium - pathology Oxygen Consumption Pneumology Proteomics - methods Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Swine Tomography, X-Ray Computed Vascular Patency Ventricular Function, Left |
| title | Continued depression of maximal oxygen consumption and mitochondrial proteomic expression despite successful coronary artery bypass grafting in a swine model of hibernation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T02%3A58%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Continued%20depression%20of%20maximal%20oxygen%20consumption%20and%20mitochondrial%20proteomic%20expression%20despite%20successful%20coronary%20artery%20bypass%20grafting%20in%20a%20swine%20model%20of%20hibernation&rft.jtitle=The%20Journal%20of%20thoracic%20and%20cardiovascular%20surgery&rft.au=Kelly,%20Rosemary%20F.,%20MD&rft.date=2011&rft.volume=141&rft.issue=1&rft.spage=261&rft.epage=268&rft.pages=261-268&rft.issn=0022-5223&rft.eissn=1097-685X&rft.coden=JTCSAQ&rft_id=info:doi/10.1016/j.jtcvs.2010.08.061&rft_dat=%3Cproquest_cross%3E820787856%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=820787856&rft_id=info:pmid/21168030&rft_els_id=S0022522310010688&rfr_iscdi=true |