γ-Secretase Inhibitor-I Enhances Radiosensitivity of Glioblastoma Cell Lines by Depleting CD133+ Tumor Cells

Background and Aims Glioblastoma is a deadly primary brain tumor with great resistance to radiotherapy. To reverse its radioresistance is important for improving prognosis. Gamma-secretase inhibitors (GSI) have been proven to have anti-tumor effects, yet the knowledge of their influences on glioblas...

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Veröffentlicht in:	Archives of medical research 2010-10, Vol.41 (7), p.519-529
Hauptverfasser:	Lin, Jun, Zhang, Xing-Mei, Yang, Jin-Cheng, Ye, Yong-Bin, Luo, Shen-Qiu
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Adult Amyloid Precursor Protein Secretases - antagonists & inhibitors Animals Antigens, CD - immunology Cell Line, Tumor - drug effects Female Glioblastoma Glioblastoma - drug therapy Glioblastoma - immunology Glioblastoma - radiotherapy Glycoproteins - immunology Humans Internal Medicine Mice Mice, Nude Oligopeptides - pharmacology Oligopeptides - therapeutic use Peptides - immunology Radiosensitivity Transplantation, Heterologous γ-Secretase Inhibitor
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