Absorption and Distribution of Naloxone in Rats after Oral and Intravenous Administration

The effect of route of administration on the absorption and distribution of naloxone, a narcotic antagonist, was investigated in rats. Plasma levels were determined by GLC. Five minutes after intravenous administration of 1 mg./kg., the plasma concentration was 258 ng./ml. Plasma levels after low or...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-09, Vol.62 (9), p.1416-1419
Hauptverfasser:	Weinstein, S.H., Pfeffer, M., Schor, J.M., Franklin, L., Mintz, M., Tutko, E.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption and distribution Absorption and distribution, naloxone hydrochloride after oral and intravenous administration, plasma levels, liver metabolism, rats Administration, Oral Animals Chromatography, Gas In Vitro Techniques Injections, Intravenous Intestinal Mucosa - metabolism Kinetics Liver - metabolism Male Mathematics Naloxone - administration & dosage Naloxone - metabolism Naloxone hydrochloride-absorption and distribution after oral and intravenous administration naloxone hydrochloride-after oral and intravenous administration Naloxone hydrochloride—absorption and distribution after oral and intravenous administration, rats plasma levels Rats Rats, Inbred Strains Time Factors
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