Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood
Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as thos...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1973-11, Vol.182 (4115), p.925-927 |
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| container_issue | 4115 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Zimmerman, Earl A. Carmel, Peter W. Husain, M. Kazim Ferin, Michel Tannenbaum, Myron Frantz, Andrew G. Robinson, Alan G. |
| description | Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 picograms per milliliter). Neurophysin concentration was approximately 25 times as high in portal as in systemic blood. By immunoperoxidase techniques, high concentrations of neurophysin were demonstrated around portal capillaries of the median eminence. These studies indicate direct secretion of vasopressin and neurophysin into the portal circulation; the quantities secreted during stress may be sufficient to exert significant effects on secretion of anterior pituitary hormone. |
| doi_str_mv | 10.1126/science.182.4115.925 |
| format | Article |
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Kazim ; Ferin, Michel ; Tannenbaum, Myron ; Frantz, Andrew G. ; Robinson, Alan G.</creator><creatorcontrib>Zimmerman, Earl A. ; Carmel, Peter W. ; Husain, M. Kazim ; Ferin, Michel ; Tannenbaum, Myron ; Frantz, Andrew G. ; Robinson, Alan G.</creatorcontrib><description>Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 picograms per milliliter). Neurophysin concentration was approximately 25 times as high in portal as in systemic blood. By immunoperoxidase techniques, high concentrations of neurophysin were demonstrated around portal capillaries of the median eminence. These studies indicate direct secretion of vasopressin and neurophysin into the portal circulation; the quantities secreted during stress may be sufficient to exert significant effects on secretion of anterior pituitary hormone.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.182.4115.925</identifier><identifier>PMID: 4200880</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Anterior pituitary ; Axons ; Axons - analysis ; Blood ; Blood plasma ; Female ; Haplorhini ; Hypothalamo-Hypophyseal System - blood supply ; Hypothalamo-Hypophyseal System - innervation ; Macaca ; Median eminence ; Neurophysins ; Neurophysins - analysis ; Neurophysins - blood ; P branes ; Peroxidases ; Physicians ; Pituitary Gland - blood supply ; Radioimmunoassay ; Secretion ; Surgeons ; Vasopressins - blood</subject><ispartof>Science (American Association for the Advancement of Science), 1973-11, Vol.182 (4115), p.925-927</ispartof><rights>Copyright 1973 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-edd98cf06219776d3a8b861f9a5f46b24f37ea6e1069ed10138467c97165f45c3</citedby><cites>FETCH-LOGICAL-c419t-edd98cf06219776d3a8b861f9a5f46b24f37ea6e1069ed10138467c97165f45c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1737742$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1737742$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4200880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimmerman, Earl A.</creatorcontrib><creatorcontrib>Carmel, Peter W.</creatorcontrib><creatorcontrib>Husain, M. Kazim</creatorcontrib><creatorcontrib>Ferin, Michel</creatorcontrib><creatorcontrib>Tannenbaum, Myron</creatorcontrib><creatorcontrib>Frantz, Andrew G.</creatorcontrib><creatorcontrib>Robinson, Alan G.</creatorcontrib><title>Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 picograms per milliliter). Neurophysin concentration was approximately 25 times as high in portal as in systemic blood. By immunoperoxidase techniques, high concentrations of neurophysin were demonstrated around portal capillaries of the median eminence. These studies indicate direct secretion of vasopressin and neurophysin into the portal circulation; the quantities secreted during stress may be sufficient to exert significant effects on secretion of anterior pituitary hormone.</description><subject>Animals</subject><subject>Anterior pituitary</subject><subject>Axons</subject><subject>Axons - analysis</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Female</subject><subject>Haplorhini</subject><subject>Hypothalamo-Hypophyseal System - blood supply</subject><subject>Hypothalamo-Hypophyseal System - innervation</subject><subject>Macaca</subject><subject>Median eminence</subject><subject>Neurophysins</subject><subject>Neurophysins - analysis</subject><subject>Neurophysins - blood</subject><subject>P branes</subject><subject>Peroxidases</subject><subject>Physicians</subject><subject>Pituitary Gland - blood supply</subject><subject>Radioimmunoassay</subject><subject>Secretion</subject><subject>Surgeons</subject><subject>Vasopressins - blood</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMlOwzAURS0EKqXwB0XKil2Cp3hgBxVQpDJIDFvLdRyaksbBThb5e1xawerp6Z53n3QAmCKYIYTZZTCVbYzNkMAZRSjPJM4PwBhBmacSQ3IIxhASlgrI82NwEsIawphJMgIjiiEUAo7B64cOrvU2hKpJdFMkT7b3rl0Ncb9K5tXnKpm5-KXpvO4q14Qkco-u-bJDMh_aX9LqOnlxvovjpnauOAVHpa6DPdvPCXi_u32bzdPF8_3D7HqRGopkl9qikMKUkGEkOWcF0WIpGCqlzkvKlpiWhFvNLIJM2gJBRARl3EiOWARyQybgYtfbevfd29CpTRWMrWvdWNcHJTCkBAkWQboDjXcheFuq1lcb7QeFoNq6VHuXKrpUW5cquoxn5_v-frmxxd_RXl7Mp7t8HTrn_zs54Zxi8gPnhXtF</recordid><startdate>19731130</startdate><enddate>19731130</enddate><creator>Zimmerman, Earl A.</creator><creator>Carmel, Peter W.</creator><creator>Husain, M. Kazim</creator><creator>Ferin, Michel</creator><creator>Tannenbaum, Myron</creator><creator>Frantz, Andrew G.</creator><creator>Robinson, Alan G.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19731130</creationdate><title>Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood</title><author>Zimmerman, Earl A. ; Carmel, Peter W. ; Husain, M. Kazim ; Ferin, Michel ; Tannenbaum, Myron ; Frantz, Andrew G. ; Robinson, Alan G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-edd98cf06219776d3a8b861f9a5f46b24f37ea6e1069ed10138467c97165f45c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Anterior pituitary</topic><topic>Axons</topic><topic>Axons - analysis</topic><topic>Blood</topic><topic>Blood plasma</topic><topic>Female</topic><topic>Haplorhini</topic><topic>Hypothalamo-Hypophyseal System - blood supply</topic><topic>Hypothalamo-Hypophyseal System - innervation</topic><topic>Macaca</topic><topic>Median eminence</topic><topic>Neurophysins</topic><topic>Neurophysins - analysis</topic><topic>Neurophysins - blood</topic><topic>P branes</topic><topic>Peroxidases</topic><topic>Physicians</topic><topic>Pituitary Gland - blood supply</topic><topic>Radioimmunoassay</topic><topic>Secretion</topic><topic>Surgeons</topic><topic>Vasopressins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimmerman, Earl A.</creatorcontrib><creatorcontrib>Carmel, Peter W.</creatorcontrib><creatorcontrib>Husain, M. Kazim</creatorcontrib><creatorcontrib>Ferin, Michel</creatorcontrib><creatorcontrib>Tannenbaum, Myron</creatorcontrib><creatorcontrib>Frantz, Andrew G.</creatorcontrib><creatorcontrib>Robinson, Alan G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimmerman, Earl A.</au><au>Carmel, Peter W.</au><au>Husain, M. Kazim</au><au>Ferin, Michel</au><au>Tannenbaum, Myron</au><au>Frantz, Andrew G.</au><au>Robinson, Alan G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1973-11-30</date><risdate>1973</risdate><volume>182</volume><issue>4115</issue><spage>925</spage><epage>927</epage><pages>925-927</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 picograms per milliliter). Neurophysin concentration was approximately 25 times as high in portal as in systemic blood. By immunoperoxidase techniques, high concentrations of neurophysin were demonstrated around portal capillaries of the median eminence. These studies indicate direct secretion of vasopressin and neurophysin into the portal circulation; the quantities secreted during stress may be sufficient to exert significant effects on secretion of anterior pituitary hormone.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>4200880</pmid><doi>10.1126/science.182.4115.925</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1973-11, Vol.182 (4115), p.925-927 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82043186 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Anterior pituitary Axons Axons - analysis Blood Blood plasma Female Haplorhini Hypothalamo-Hypophyseal System - blood supply Hypothalamo-Hypophyseal System - innervation Macaca Median eminence Neurophysins Neurophysins - analysis Neurophysins - blood P branes Peroxidases Physicians Pituitary Gland - blood supply Radioimmunoassay Secretion Surgeons Vasopressins - blood |
| title | Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood |
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