Determination of α-keto acids as silylated oximes in urine and serum by combined gas chromatography-mass spectrometry

Nine α-keto acids in serum and urine were analyzed by gas chromatography as their oxime-trimethylsilylated derivatives, following oxime formation with hydroxylamine in pyridine and silylation with BSA containing 10% TMCS. The oxime-TMS derivatives were identified by both low- and high-resolution mas...

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