Gammopathy in Hamsters with Xenogeneic Tumours
A PREVIOUS communication described the heterotransplantation of human heteroploid cells derived from a prostatic adenoma (MA 160) into nonimmunosuppressed 2-d-old hamsters1. Most animals receiving subcutaneous implants of 107 cells rejected them after 14 d (regressors). In some (27%), however, there...
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| Veröffentlicht in: | Nature. New biology (London) 1973-10, Vol.245 (144), p.158-160 |
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| creator | RICHMAN, ALAN VE DEFENDI, VITTORIO |
| description | A PREVIOUS communication described the heterotransplantation of human heteroploid cells derived from a prostatic adenoma (MA 160) into nonimmunosuppressed 2-d-old hamsters1. Most animals receiving subcutaneous implants of 107 cells rejected them after 14 d (regressors). In some (27%), however, there was progressive tumour growth (persistors). This was associated with morphological signs of immunological stimulation as evidenced by a pronounced proliferation of plasma cells in lymph nodes, hepatic portal areas, spleen and kidneys. One biological expression of this proliferation was the presence of antibody directed against membrane antigens of living MA160 cells. At the time of peak tumour growth, fluorescent antibody titres as large as 1:1,280 were demonstrated in sera from animals with large tumours. |
| doi_str_mv | 10.1038/newbio245158a0 |
| format | Article |
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Most animals receiving subcutaneous implants of 107 cells rejected them after 14 d (regressors). In some (27%), however, there was progressive tumour growth (persistors). This was associated with morphological signs of immunological stimulation as evidenced by a pronounced proliferation of plasma cells in lymph nodes, hepatic portal areas, spleen and kidneys. One biological expression of this proliferation was the presence of antibody directed against membrane antigens of living MA160 cells. At the time of peak tumour growth, fluorescent antibody titres as large as 1:1,280 were demonstrated in sera from animals with large tumours.</description><identifier>ISSN: 0090-0028</identifier><identifier>EISSN: 2058-1092</identifier><identifier>DOI: 10.1038/newbio245158a0</identifier><identifier>PMID: 4200666</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenoma ; Animals ; Biomedical and Life Sciences ; Blood Protein Electrophoresis ; Cell Line ; Cricetinae ; Fluorescent Antibody Technique ; Humans ; Hypergammaglobulinemia - etiology ; Immunodiffusion ; Immunoelectrophoresis ; Immunoglobulin G - analysis ; letters-to-editor ; Life Sciences ; Male ; Neoplasm Transplantation ; Neoplasms, Experimental - complications ; Neoplasms, Experimental - immunology ; Prostatic Neoplasms ; Transplantation, Heterologous</subject><ispartof>Nature. 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At the time of peak tumour growth, fluorescent antibody titres as large as 1:1,280 were demonstrated in sera from animals with large tumours.</description><subject>Adenoma</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Blood Protein Electrophoresis</subject><subject>Cell Line</subject><subject>Cricetinae</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Hypergammaglobulinemia - etiology</subject><subject>Immunodiffusion</subject><subject>Immunoelectrophoresis</subject><subject>Immunoglobulin G - analysis</subject><subject>letters-to-editor</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - complications</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Prostatic Neoplasms</subject><subject>Transplantation, Heterologous</subject><issn>0090-0028</issn><issn>2058-1092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFLw0AQhRdRaq1evQk5iLe0s5PdZPcoRVuh4MEevIXtdtKmNJu6m1D67420FBQ8zeG99w3vMXbPYcghUSNH-0VZo5BcKgMXrI8gVcxB4yXrA2iIAVBds5sQNgAJFxn2WE8gQJqmfTacmKqqd6ZZH6LSRVNThYZ8iPZls44-ydUrclTaaN5WdevDLbsqzDbQ3ekO2Mfry3w8jWfvk7fx8yy23YcmRltgYQgJtdRWmiRVBSdaWiwyqflSGcoECS0FKcxQi0SLVHJBZFFRMmBPR-rO118thSavymBpuzWO6jbkCiFJhcw64_BotL4OwVOR73xZGX_IOeQ_8-S_5-kCDydyu6hoebaf9uj00VEPneJW5PNNV9t1Vf8nPh4TzjStpzPxj-0bcI19hw</recordid><startdate>19731003</startdate><enddate>19731003</enddate><creator>RICHMAN, ALAN VE</creator><creator>DEFENDI, VITTORIO</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19731003</creationdate><title>Gammopathy in Hamsters with Xenogeneic Tumours</title><author>RICHMAN, ALAN VE ; DEFENDI, VITTORIO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-2cf2fae2e2959c5a368f1eedc2f7591d8ae74e4954e8272943946514eec28e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Adenoma</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Blood Protein Electrophoresis</topic><topic>Cell Line</topic><topic>Cricetinae</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Hypergammaglobulinemia - etiology</topic><topic>Immunodiffusion</topic><topic>Immunoelectrophoresis</topic><topic>Immunoglobulin G - analysis</topic><topic>letters-to-editor</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - complications</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Prostatic Neoplasms</topic><topic>Transplantation, Heterologous</topic><toplevel>online_resources</toplevel><creatorcontrib>RICHMAN, ALAN VE</creatorcontrib><creatorcontrib>DEFENDI, VITTORIO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature. New biology (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RICHMAN, ALAN VE</au><au>DEFENDI, VITTORIO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gammopathy in Hamsters with Xenogeneic Tumours</atitle><jtitle>Nature. New biology (London)</jtitle><stitle>Nature New Biology</stitle><addtitle>Nat New Biol</addtitle><date>1973-10-03</date><risdate>1973</risdate><volume>245</volume><issue>144</issue><spage>158</spage><epage>160</epage><pages>158-160</pages><issn>0090-0028</issn><eissn>2058-1092</eissn><abstract>A PREVIOUS communication described the heterotransplantation of human heteroploid cells derived from a prostatic adenoma (MA 160) into nonimmunosuppressed 2-d-old hamsters1. Most animals receiving subcutaneous implants of 107 cells rejected them after 14 d (regressors). In some (27%), however, there was progressive tumour growth (persistors). This was associated with morphological signs of immunological stimulation as evidenced by a pronounced proliferation of plasma cells in lymph nodes, hepatic portal areas, spleen and kidneys. One biological expression of this proliferation was the presence of antibody directed against membrane antigens of living MA160 cells. At the time of peak tumour growth, fluorescent antibody titres as large as 1:1,280 were demonstrated in sera from animals with large tumours.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4200666</pmid><doi>10.1038/newbio245158a0</doi><tpages>3</tpages></addata></record> |
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| subjects | Adenoma Animals Biomedical and Life Sciences Blood Protein Electrophoresis Cell Line Cricetinae Fluorescent Antibody Technique Humans Hypergammaglobulinemia - etiology Immunodiffusion Immunoelectrophoresis Immunoglobulin G - analysis letters-to-editor Life Sciences Male Neoplasm Transplantation Neoplasms, Experimental - complications Neoplasms, Experimental - immunology Prostatic Neoplasms Transplantation, Heterologous |
| title | Gammopathy in Hamsters with Xenogeneic Tumours |
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