The relationship of erythromonocytic leukemia to other myeloproliferative disorders
The evolution of erythromonocytic leukemia has been studied in two patients. One (Case 1) presented with DiGuglielmo's syndrome manifested by erythroid hyperplasia, dyserythropoiesis, periodic acid-Schiff-positive erythroblasts, normal heme biosynthesis and ineffective erythropoiesis. In vitro...
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| Veröffentlicht in: | The American journal of medicine 1973-10, Vol.55 (4), p.542-548 |
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| container_title | The American journal of medicine |
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| creator | Shaw, Michael T. Bottomley, Sylvia S. Bottomley, Richard H. Hussein, Khader K. |
| description | The evolution of erythromonocytic leukemia has been studied in two patients. One (Case 1) presented with DiGuglielmo's syndrome manifested by erythroid hyperplasia, dyserythropoiesis, periodic acid-Schiff-positive erythroblasts, normal heme biosynthesis and ineffective erythropoiesis. In vitro stimulation of the patient's bone marrow with exogenous erythropoietin demonstrated decreased responsiveness. Progressive infiltration of the bone marrow and peripheral blood with primitive monocytic cells was accompanied by an increased number of hypodiploid cells. The second patient (Case 2) presented with a picture of polycythemia vera, progressing to myelofibrosis and terminating as erythromonocytic leukemia in which a paroxysmal nocturnal hemoglobinuria-like defect was demonstrated in the erythroid cells. The leukemic cells were hyperdiploid. It is concluded that erythromonocytic leukemia may result from clonal evolution occurring in any of the myeloproliferative syndromes. |
| doi_str_mv | 10.1016/0002-9343(73)90212-X |
| format | Article |
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One (Case 1) presented with DiGuglielmo's syndrome manifested by erythroid hyperplasia, dyserythropoiesis, periodic acid-Schiff-positive erythroblasts, normal heme biosynthesis and ineffective erythropoiesis. In vitro stimulation of the patient's bone marrow with exogenous erythropoietin demonstrated decreased responsiveness. Progressive infiltration of the bone marrow and peripheral blood with primitive monocytic cells was accompanied by an increased number of hypodiploid cells. The second patient (Case 2) presented with a picture of polycythemia vera, progressing to myelofibrosis and terminating as erythromonocytic leukemia in which a paroxysmal nocturnal hemoglobinuria-like defect was demonstrated in the erythroid cells. The leukemic cells were hyperdiploid. It is concluded that erythromonocytic leukemia may result from clonal evolution occurring in any of the myeloproliferative syndromes.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(73)90212-X</identifier><identifier>PMID: 4355172</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Bone Marrow Cells ; Bone Marrow Examination ; Chromosomes - analysis ; Clone Cells ; Erythropoiesis ; Female ; Heme - biosynthesis ; Hemoglobinuria, Paroxysmal - etiology ; Humans ; Leukemia, Erythroblastic, Acute - complications ; Leukemia, Erythroblastic, Acute - diagnosis ; Leukemia, Erythroblastic, Acute - etiology ; Leukemia, Erythroblastic, Acute - pathology ; Leukemia, Myeloid - etiology ; Male ; Middle Aged ; Myeloproliferative Disorders - pathology ; Periodic Acid ; Polycythemia Vera - complications ; Primary Myelofibrosis - complications ; Primary Myelofibrosis - pathology ; Syndrome</subject><ispartof>The American journal of medicine, 1973-10, Vol.55 (4), p.542-548</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b584424b31396df6e1d97aeaaf8e62348d08451395c519a7c5efe326468e44953</citedby><cites>FETCH-LOGICAL-c357t-b584424b31396df6e1d97aeaaf8e62348d08451395c519a7c5efe326468e44953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000293437390212X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4355172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaw, Michael T.</creatorcontrib><creatorcontrib>Bottomley, Sylvia S.</creatorcontrib><creatorcontrib>Bottomley, Richard H.</creatorcontrib><creatorcontrib>Hussein, Khader K.</creatorcontrib><title>The relationship of erythromonocytic leukemia to other myeloproliferative disorders</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>The evolution of erythromonocytic leukemia has been studied in two patients. One (Case 1) presented with DiGuglielmo's syndrome manifested by erythroid hyperplasia, dyserythropoiesis, periodic acid-Schiff-positive erythroblasts, normal heme biosynthesis and ineffective erythropoiesis. In vitro stimulation of the patient's bone marrow with exogenous erythropoietin demonstrated decreased responsiveness. Progressive infiltration of the bone marrow and peripheral blood with primitive monocytic cells was accompanied by an increased number of hypodiploid cells. The second patient (Case 2) presented with a picture of polycythemia vera, progressing to myelofibrosis and terminating as erythromonocytic leukemia in which a paroxysmal nocturnal hemoglobinuria-like defect was demonstrated in the erythroid cells. The leukemic cells were hyperdiploid. It is concluded that erythromonocytic leukemia may result from clonal evolution occurring in any of the myeloproliferative syndromes.</description><subject>Aged</subject><subject>Bone Marrow Cells</subject><subject>Bone Marrow Examination</subject><subject>Chromosomes - analysis</subject><subject>Clone Cells</subject><subject>Erythropoiesis</subject><subject>Female</subject><subject>Heme - biosynthesis</subject><subject>Hemoglobinuria, Paroxysmal - etiology</subject><subject>Humans</subject><subject>Leukemia, Erythroblastic, Acute - complications</subject><subject>Leukemia, Erythroblastic, Acute - diagnosis</subject><subject>Leukemia, Erythroblastic, Acute - etiology</subject><subject>Leukemia, Erythroblastic, Acute - pathology</subject><subject>Leukemia, Myeloid - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myeloproliferative Disorders - pathology</subject><subject>Periodic Acid</subject><subject>Polycythemia Vera - complications</subject><subject>Primary Myelofibrosis - complications</subject><subject>Primary Myelofibrosis - pathology</subject><subject>Syndrome</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRaq3-A4WsRBfReSfZCFJ8QcGFFbobppMbMpp06kxSyL93akuXri6Xc859fAhdEnxHMJH3GGOaFoyzm4zdFpgSmi6O0JgIIdKMSHqMxgfLKToL4Su2uBByhEacCUEyOkYf8xoSD43urFuF2q4TVyXgh672rnUrZ4bOmqSB_htaq5POJa6rwSftAI1be9fYCnwMbyApbXC-BB_O0UmlmwAX-zpBn89P8-lrOnt_eZs-zlLDRNalS5FzTvmSEVbIspJAyiLToHWVg6SM5yXOuYiiMIIUOjMCKmBUcpkD54VgE3S9mxvv-OkhdKq1wUDT6BW4PqicYiZwQaOR74zGuxA8VGrtbav9oAhWW5ZqC0ptQamMqT-WahFjV_v5_bKF8hDaw4v6w06H-OTGglfBWFgZKK0H06nS2f8X_AKPkYRN</recordid><startdate>197310</startdate><enddate>197310</enddate><creator>Shaw, Michael T.</creator><creator>Bottomley, Sylvia S.</creator><creator>Bottomley, Richard H.</creator><creator>Hussein, Khader K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197310</creationdate><title>The relationship of erythromonocytic leukemia to other myeloproliferative disorders</title><author>Shaw, Michael T. ; Bottomley, Sylvia S. ; Bottomley, Richard H. ; Hussein, Khader K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b584424b31396df6e1d97aeaaf8e62348d08451395c519a7c5efe326468e44953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Aged</topic><topic>Bone Marrow Cells</topic><topic>Bone Marrow Examination</topic><topic>Chromosomes - analysis</topic><topic>Clone Cells</topic><topic>Erythropoiesis</topic><topic>Female</topic><topic>Heme - biosynthesis</topic><topic>Hemoglobinuria, Paroxysmal - etiology</topic><topic>Humans</topic><topic>Leukemia, Erythroblastic, Acute - complications</topic><topic>Leukemia, Erythroblastic, Acute - diagnosis</topic><topic>Leukemia, Erythroblastic, Acute - etiology</topic><topic>Leukemia, Erythroblastic, Acute - pathology</topic><topic>Leukemia, Myeloid - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myeloproliferative Disorders - pathology</topic><topic>Periodic Acid</topic><topic>Polycythemia Vera - complications</topic><topic>Primary Myelofibrosis - complications</topic><topic>Primary Myelofibrosis - pathology</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaw, Michael T.</creatorcontrib><creatorcontrib>Bottomley, Sylvia S.</creatorcontrib><creatorcontrib>Bottomley, Richard H.</creatorcontrib><creatorcontrib>Hussein, Khader K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaw, Michael T.</au><au>Bottomley, Sylvia S.</au><au>Bottomley, Richard H.</au><au>Hussein, Khader K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship of erythromonocytic leukemia to other myeloproliferative disorders</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1973-10</date><risdate>1973</risdate><volume>55</volume><issue>4</issue><spage>542</spage><epage>548</epage><pages>542-548</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>The evolution of erythromonocytic leukemia has been studied in two patients. One (Case 1) presented with DiGuglielmo's syndrome manifested by erythroid hyperplasia, dyserythropoiesis, periodic acid-Schiff-positive erythroblasts, normal heme biosynthesis and ineffective erythropoiesis. In vitro stimulation of the patient's bone marrow with exogenous erythropoietin demonstrated decreased responsiveness. Progressive infiltration of the bone marrow and peripheral blood with primitive monocytic cells was accompanied by an increased number of hypodiploid cells. The second patient (Case 2) presented with a picture of polycythemia vera, progressing to myelofibrosis and terminating as erythromonocytic leukemia in which a paroxysmal nocturnal hemoglobinuria-like defect was demonstrated in the erythroid cells. The leukemic cells were hyperdiploid. It is concluded that erythromonocytic leukemia may result from clonal evolution occurring in any of the myeloproliferative syndromes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4355172</pmid><doi>10.1016/0002-9343(73)90212-X</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Bone Marrow Cells Bone Marrow Examination Chromosomes - analysis Clone Cells Erythropoiesis Female Heme - biosynthesis Hemoglobinuria, Paroxysmal - etiology Humans Leukemia, Erythroblastic, Acute - complications Leukemia, Erythroblastic, Acute - diagnosis Leukemia, Erythroblastic, Acute - etiology Leukemia, Erythroblastic, Acute - pathology Leukemia, Myeloid - etiology Male Middle Aged Myeloproliferative Disorders - pathology Periodic Acid Polycythemia Vera - complications Primary Myelofibrosis - complications Primary Myelofibrosis - pathology Syndrome |
| title | The relationship of erythromonocytic leukemia to other myeloproliferative disorders |
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