The dosimetry and lethal effects of maternally administered phosphorus-32 after 14 and 17 days of gestation in the rat
Pregnant female albino rats were given graded doses of radiophosphorus after 14 or 17 days of gestation and sacrificed at intervals after injection through birth. One millicurie or less of P-32 did not increase prenatal mortality after administration on either of these two days. Two millicuries prod...
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| Veröffentlicht in: | Phys. in Med. Biol 1957-10, Vol.2 (2), p.157-168 |
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| container_title | Phys. in Med. Biol |
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| creator | Sikov, Melvin R Lofstrom, James E |
| description | Pregnant female albino rats were given graded doses of radiophosphorus after 14 or 17 days of gestation and sacrificed at intervals after injection through birth. One millicurie or less of P-32 did not increase prenatal mortality after administration on either of these two days. Two millicuries produced prenatal deaths when administered after 14 days of gestation but not after I7 days; some deaths attributable to the trauma of parturition were noted in both cases. A depression of the growth curve and of birth weight was produced by doses of 0.4 mc and larger after 14 days and by doses of 0.6 mc and above after 17 days of gestation. The curves of accumulated radiation dose to the whole fetus and to various organs and systems as interpolated to one millicurie are presented and discussed. (auth) |
| doi_str_mv | 10.1088/0031-9155/2/2/303 |
| format | Article |
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One millicurie or less of P-32 did not increase prenatal mortality after administration on either of these two days. Two millicuries produced prenatal deaths when administered after 14 days of gestation but not after I7 days; some deaths attributable to the trauma of parturition were noted in both cases. A depression of the growth curve and of birth weight was produced by doses of 0.4 mc and larger after 14 days and by doses of 0.6 mc and above after 17 days of gestation. The curves of accumulated radiation dose to the whole fetus and to various organs and systems as interpolated to one millicurie are presented and discussed. 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Biol</title><addtitle>Phys Med Biol</addtitle><description>Pregnant female albino rats were given graded doses of radiophosphorus after 14 or 17 days of gestation and sacrificed at intervals after injection through birth. One millicurie or less of P-32 did not increase prenatal mortality after administration on either of these two days. Two millicuries produced prenatal deaths when administered after 14 days of gestation but not after I7 days; some deaths attributable to the trauma of parturition were noted in both cases. A depression of the growth curve and of birth weight was produced by doses of 0.4 mc and larger after 14 days and by doses of 0.6 mc and above after 17 days of gestation. The curves of accumulated radiation dose to the whole fetus and to various organs and systems as interpolated to one millicurie are presented and discussed. 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Two millicuries produced prenatal deaths when administered after 14 days of gestation but not after I7 days; some deaths attributable to the trauma of parturition were noted in both cases. A depression of the growth curve and of birth weight was produced by doses of 0.4 mc and larger after 14 days and by doses of 0.6 mc and above after 17 days of gestation. The curves of accumulated radiation dose to the whole fetus and to various organs and systems as interpolated to one millicurie are presented and discussed. (auth)</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>13484468</pmid><doi>10.1088/0031-9155/2/2/303</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Phys. in Med. Biol, 1957-10, Vol.2 (2), p.157-168 |
| issn | 0031-9155 1361-6560 |
| language | eng |
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| source | MEDLINE; Institute of Physics Journals |
| subjects | AGE Animals BIOLOGY AND MEDICINE Female Fetus - radiation effects FETUSES MEASURED VALUES Old Medline Phosphorus PHOSPHORUS 32 Phosphorus Radioisotopes PREGNANCY Pregnancy - physiology Radiation RADIATION DOSES RADIATION INJURIES Radioactivity Radioisotopes RATS SEX TISSUES |
| title | The dosimetry and lethal effects of maternally administered phosphorus-32 after 14 and 17 days of gestation in the rat |
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