Cholesterol synthesis and metabolism as a function of unpredictable shock stimulation
Rats fed a high lipid diet and also exposed to unavoidable and unpredictable grid shock for 2 and 8 days showed higher levels of accumulated chemical cholesterol in aorta, kidney, liver and serum as compared to control rats fed only the high lipid diet. Thirty days of shock stress produced similar r...
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| Veröffentlicht in: | Physiology & behavior 1973-07, Vol.11 (1), p.107-110 |
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| container_title | Physiology & behavior |
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| creator | Paré, William P. Rothfeld, Benjamin Isom, Kile E. Varady, Alexander |
| description | Rats fed a high lipid diet and also exposed to unavoidable and unpredictable grid shock for 2 and 8 days showed higher levels of accumulated chemical cholesterol in aorta, kidney, liver and serum as compared to control rats fed only the high lipid diet. Thirty days of shock stress produced similar results except that kidney tissue revealed lower and nonsignificant levels of accumulated cholesterol. A differential cholesterol clearing mechanism for the various tissues is postulated to explain the relative vulnerability of aorta, liver and kidney to stress-induced cholesterol deposition. |
| doi_str_mv | 10.1016/0031-9384(73)90131-5 |
| format | Article |
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Thirty days of shock stress produced similar results except that kidney tissue revealed lower and nonsignificant levels of accumulated cholesterol. A differential cholesterol clearing mechanism for the various tissues is postulated to explain the relative vulnerability of aorta, liver and kidney to stress-induced cholesterol deposition.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(73)90131-5</identifier><identifier>PMID: 4738874</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Aorta ; Aorta - analysis ; Aorta - metabolism ; Arteriosclerosis ; Body Weight ; Carbon Isotopes ; Cholesterol - analysis ; Cholesterol - biosynthesis ; Cholesterol - blood ; Cholesterol - metabolism ; Cholesterol deposition ; Disease Models, Animal ; Electroshock ; Humans ; Kidney ; Kidney - analysis ; Kidney - metabolism ; Liver ; Liver - analysis ; Liver - metabolism ; Male ; Rat ; Rats ; Serum ; Stress ; Stress, Psychological ; Unpredictable shock</subject><ispartof>Physiology & behavior, 1973-07, Vol.11 (1), p.107-110</ispartof><rights>1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-bc09fd57602e2764ebf7f5aa0c4f638a843fd8d9ada8985f256d8e61aaa34e9b3</citedby><cites>FETCH-LOGICAL-c357t-bc09fd57602e2764ebf7f5aa0c4f638a843fd8d9ada8985f256d8e61aaa34e9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0031938473901315$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4738874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paré, William P.</creatorcontrib><creatorcontrib>Rothfeld, Benjamin</creatorcontrib><creatorcontrib>Isom, Kile E.</creatorcontrib><creatorcontrib>Varady, Alexander</creatorcontrib><title>Cholesterol synthesis and metabolism as a function of unpredictable shock stimulation</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Rats fed a high lipid diet and also exposed to unavoidable and unpredictable grid shock for 2 and 8 days showed higher levels of accumulated chemical cholesterol in aorta, kidney, liver and serum as compared to control rats fed only the high lipid diet. Thirty days of shock stress produced similar results except that kidney tissue revealed lower and nonsignificant levels of accumulated cholesterol. A differential cholesterol clearing mechanism for the various tissues is postulated to explain the relative vulnerability of aorta, liver and kidney to stress-induced cholesterol deposition.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - analysis</subject><subject>Aorta - metabolism</subject><subject>Arteriosclerosis</subject><subject>Body Weight</subject><subject>Carbon Isotopes</subject><subject>Cholesterol - analysis</subject><subject>Cholesterol - biosynthesis</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol deposition</subject><subject>Disease Models, Animal</subject><subject>Electroshock</subject><subject>Humans</subject><subject>Kidney</subject><subject>Kidney - analysis</subject><subject>Kidney - metabolism</subject><subject>Liver</subject><subject>Liver - analysis</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Rat</subject><subject>Rats</subject><subject>Serum</subject><subject>Stress</subject><subject>Stress, Psychological</subject><subject>Unpredictable shock</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQgIMotT7-gUJOoofVpMlushdBii8QvFjwFrLJhEZ3NzXZFfrvTW3xaC5DZr6ZYT6Ezii5poRWN4QwWtRM8kvBrmpC86_cQ1MqBStKIt730fQPOURHKX2Q_BhnEzThgkkp-BQt5svQQhoghhandT8sIfmEdW9xB4NuQutTh3XOYDf2ZvChx8HhsV9FsN5kogWclsF84jT4bmz1BjlBB063CU538RgtHu7f5k_Fy-vj8_zupTCsFEPRGFI7W4qKzGAmKg6NE67UmhjuKia15MxZaWtttaxl6WZlZSVUVGvNONQNO0YX27mrGL7GfIbqfDLQtrqHMCYlZ4RKImgG-RY0MaQUwalV9J2Oa0WJ2thUG1Vqo0oJpn5tqjK3ne_mj00H9q9ppy_Xb7d1yEd-e4gqGQ-9yWoimEHZ4P9f8AM8uoW2</recordid><startdate>197307</startdate><enddate>197307</enddate><creator>Paré, William P.</creator><creator>Rothfeld, Benjamin</creator><creator>Isom, Kile E.</creator><creator>Varady, Alexander</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197307</creationdate><title>Cholesterol synthesis and metabolism as a function of unpredictable shock stimulation</title><author>Paré, William P. ; Rothfeld, Benjamin ; Isom, Kile E. ; Varady, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-bc09fd57602e2764ebf7f5aa0c4f638a843fd8d9ada8985f256d8e61aaa34e9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta - analysis</topic><topic>Aorta - metabolism</topic><topic>Arteriosclerosis</topic><topic>Body Weight</topic><topic>Carbon Isotopes</topic><topic>Cholesterol - analysis</topic><topic>Cholesterol - biosynthesis</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - metabolism</topic><topic>Cholesterol deposition</topic><topic>Disease Models, Animal</topic><topic>Electroshock</topic><topic>Humans</topic><topic>Kidney</topic><topic>Kidney - analysis</topic><topic>Kidney - metabolism</topic><topic>Liver</topic><topic>Liver - analysis</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Rat</topic><topic>Rats</topic><topic>Serum</topic><topic>Stress</topic><topic>Stress, Psychological</topic><topic>Unpredictable shock</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paré, William P.</creatorcontrib><creatorcontrib>Rothfeld, Benjamin</creatorcontrib><creatorcontrib>Isom, Kile E.</creatorcontrib><creatorcontrib>Varady, Alexander</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paré, William P.</au><au>Rothfeld, Benjamin</au><au>Isom, Kile E.</au><au>Varady, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol synthesis and metabolism as a function of unpredictable shock stimulation</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1973-07</date><risdate>1973</risdate><volume>11</volume><issue>1</issue><spage>107</spage><epage>110</epage><pages>107-110</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Rats fed a high lipid diet and also exposed to unavoidable and unpredictable grid shock for 2 and 8 days showed higher levels of accumulated chemical cholesterol in aorta, kidney, liver and serum as compared to control rats fed only the high lipid diet. 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| fulltext | fulltext |
| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 1973-07, Vol.11 (1), p.107-110 |
| issn | 0031-9384 1873-507X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Aorta Aorta - analysis Aorta - metabolism Arteriosclerosis Body Weight Carbon Isotopes Cholesterol - analysis Cholesterol - biosynthesis Cholesterol - blood Cholesterol - metabolism Cholesterol deposition Disease Models, Animal Electroshock Humans Kidney Kidney - analysis Kidney - metabolism Liver Liver - analysis Liver - metabolism Male Rat Rats Serum Stress Stress, Psychological Unpredictable shock |
| title | Cholesterol synthesis and metabolism as a function of unpredictable shock stimulation |
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